LCOR and LRP1B

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	LRP1B
Description		ligand dependent nuclear receptor corepressor	LDL receptor related protein 1B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Endocytosis Receptor-mediated Endocytosis Protein Transport
Pathways
Drugs
Diseases
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Aging ( 19367585) Asthma (childhood onset) ( 27611488) Asthma and eczema ( 34155719) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 25673413 20935630 28892062) Body size at age 10 ( 32376654) Cataracts ( 34127677) Cerebellum white matter volume ( 31530798) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive performance (processing speed) ( 31598132) Congenital heart disease (inherited effect) ( 28468790) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dietary fat liking ( 32516399) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Erectile dysfunction and prostate cancer treatment ( 20932654) Estimated glomerular filtration rate ( 31217584) Facial attractiveness (male raters) ( 30946739) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate in chronic kidney disease ( 26420894) Hepcidin/ferritin ratio ( 27846281) Household income (MTAG) ( 31844048) Influenza A (H1N1) infection ( 26379185) Keratoconus ( 33649486) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 21102462 25231870) Mood instability ( 31168069) Motion sickness ( 25628336) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Optic nerve measurement (disc area) ( 20395239) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Periodontitis (CDC/AAP) ( 24024966) Post bronchodilator FEV1 ( 26634245) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Severe influenza A (H1N1) infection ( 26379185) Type 1 diabetes ( 32005708) Type 2 diabetes ( 30130595)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	8 interacting genes: APP DYRK1A FGA LCOR LRPAP1 PLAT PLAUR SERPINE1
Entrez ID		84458	53353
HPRD ID		07609	16383
Ensembl ID		ENSG00000196233	ENSG00000168702
Uniprot IDs		Q96JN0	Q9NZR2
PDB IDs		2COB 6V3X 6V3Y
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Signaling Receptor Binding Regulation Of Hemostasis Regulation Of Protein Maturation Regulation Of Blood Coagulation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Fibrinolysis Negative Regulation Of Protein Maturation Regulation Of Wound Healing Regulation Of Response To Wounding Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Serine Protease Inhibitor Complex Regulation Of Protein Metabolic Process Regulation Of Protein Processing Platelet Alpha Granule Lumen Negative Regulation Of Plasminogen Activation Negative Regulation Of Wound Healing Negative Regulation Of Gene Expression Regulation Of Body Fluid Levels Cell Surface Negative Regulation Of Multicellular Organismal Process Plasminogen Activation Negative Regulation Of Fibrinolysis Blood Coagulation Coagulation Hemostasis Regulation Of Receptor-mediated Endocytosis Regulation Of Proteolysis Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Platelet Alpha Granule Regulation Of Apoptotic Signaling Pathway Regulation Of Amyloid-beta Clearance Negative Regulation Of Biosynthetic Process Negative Regulation Of Signaling Endosome Lumen Negative Regulation Of Cell Communication Negative Regulation Of Protein Processing Positive Regulation Of Monocyte Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Blood Coagulation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Coagulation Regulation Of Biological Quality Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Monocyte Chemotaxis Negative Regulation Of Endothelial Cell Apoptotic Process
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