RAP1GAP and ZBTB12

Number of citations of the paper that reports this interaction (PMID 8939933)
11

Data Source:
HPRD (two hybrid, in vitro)

		RAP1GAP	ZBTB12
Gene Name		RAP1 GTPase activating protein	zinc finger and BTB domain containing 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol Membrane	Nucleus
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Ras GTPase Binding Protein Homodimerization Activity Rap GTPase Activator Activity	DNA Binding Metal Ion Binding
	Biological Process	Signal Transduction Metabolic Process Regulation Of Ras GTPase Activity Positive Regulation Of Rap GTPase Activity Negative Regulation Of Microvillus Assembly	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Rap1 signalling Adaptive Immune System
Drugs
Diseases
GWAS		Liver enzyme levels ( 18940312)	Hematology traits ( 23263863)
Protein-Protein Interactions		15 interactors: BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B MLLT4 PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12	2 interactors: HRAS RAP1GAP
Entrez ID		5909	221527
HPRD ID		02609	15691
Ensembl ID		ENSG00000076864	ENSG00000204366
Uniprot IDs		P47736	Q9Y330
PDB IDs		1SRQ 3BRW
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Catalytic Activity Mitotic Nuclear Envelope Disassembly Regulation Of Synaptic Vesicle Transport Nuclear Envelope Disassembly Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Neurotransmitter Secretion Activation Of MAPKK Activity Nuclear Envelope Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rap GTPase Activity Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Positive Regulation Of Protein Metabolic Process Phosphorylation Regulation Of Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neurotransmitter Secretion Regulation Of Rap GTPase Activity Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Neurotransmitter Transport Regulation Of Rap Protein Signal Transduction Regulation Of Exocytosis Positive Regulation Of MAPK Cascade Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Endothelial Barrier Protein Localization To Chromosome Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Kinase Activity	Regulation Of Cell Projection Assembly Negative Regulation Of Microvillus Assembly Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rac Protein Signal Transduction Regulation Of Cell Projection Organization Regulation Of Microvillus Assembly Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Ruffle Assembly Regulation Of Ras GTPase Activity Regulation Of Ras Protein Signal Transduction Regulation Of MiRNA Metabolic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Negative Regulation Of Rho GTPase Activity Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Rap GTPase Activity Regulation Of Ruffle Assembly Negative Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Hydrolase Activity Regulation Of Rap Protein Signal Transduction Cellular Senescence Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of GTPase Activity Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Regulation Of Actin Cytoskeleton Reorganization Social Behavior Positive Regulation Of Wound Healing Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Catalytic Activity Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Visual Learning Visual Behavior Activation Of MAPKK Activity Lung Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Replication Cell Aging Regulation Of Cellular Component Organization Associative Learning Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway
Tagcloud ?		autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1
Tagcloud (Difference) ?		autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1
Tagcloud (Intersection) ?