LCOR and TF

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	TF
Description		ligand dependent nuclear receptor corepressor	transferrin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Region Extracellular Space Endosome Early Endosome Late Endosome Endoplasmic Reticulum Lumen Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle HFE-transferrin Receptor Complex
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Enzyme Binding Iron Chaperone Activity Transmembrane Transporter Binding Metal Ion Binding Transferrin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Cell Surface Receptor Signaling Pathway Response To Bacterium Antibacterial Humoral Response Osteoclast Differentiation Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor-mediated Endocytosis Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Iron Ion Iron Ion Export Across Plasma Membrane
Pathways			Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation Iron uptake and transport Transferrin endocytosis and recycling
Drugs			Cisplatin Isoflurophate Aluminium Iron Zinc Manganese Copper Dichlorvos Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Alcohol consumption (transferrin glycosylation) ( 21665994) HDL cholesterol levels ( 32203549) Hepcidin levels ( 21785125) Hereditary hemochromatosis-related traits (HFE mutation homozygotes) ( 25457201) Iron status biomarkers ( 21208937 21483845 25224454 19084217) Iron status biomarkers (iron levels) ( 28334935 33536631 25352340) Iron status biomarkers (total iron binding capacity) ( 33536631 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 33536631 25352340 28334935) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	47 interacting genes: AQP9 CALR CANX CLDN5 CPLX4 CUBN DRD2 ELOVL4 ERGIC3 FAM209A FAM210B FKBP7 GJB1 GOLM1 GPR42 GPX8 GRB2 HSD17B13 HSP90AA1 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 LCOR LEUTX PGRMC2 RMDN3 RSPH1 SH3BP2 SLC10A6 SLC26A6 SLC35H1 SMAD3 SORT1 SPINT1 SYT2 TFR2 TFRC TIMELESS TMEM52B TUBB3 VKORC1
Entrez ID		84458	7018
HPRD ID		07609	01811
Ensembl ID		ENSG00000196233	ENSG00000091513
Uniprot IDs		Q96JN0	A0PJA6 P02787 Q06AH7
PDB IDs		2COB 6V3X 6V3Y	1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W 4X1B 4X1D 5DYH 5H52 5WTD 5X5P 5Y6K 6CTC 6D03 6D04 6D05 6JAS 6SOY 6SOZ 6UJ6 7FFM 7FFU 7Q1L 8BRC 9H49 9H4V
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Insulin-like Growth Factor II Binding Insulin-like Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor I Binding Growth Factor Binding Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Ternary Complex Type B Pancreatic Cell Proliferation Striated Muscle Cell Differentiation Osteoblast Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Transferrin Receptor Activity Receptor-mediated Endocytosis Muscle Cell Differentiation Regulation Of Cell Growth Response To Estradiol Positive Regulation Of Activated T Cell Proliferation Insulin Receptor Signaling Pathway Fibronectin Binding Morphogenesis Of A Branching Structure Intracellular Chemical Homeostasis Response To Iron Ion Cellular Developmental Process Epithelial Cell Proliferation Regulation Of Glucose Metabolic Process Protein Binding Positive Regulation Of Cellular Component Organization Developmental Process Endocytosis Regulation Of Activated T Cell Proliferation Positive Regulation Of T Cell Proliferation HFE-transferrin Receptor Complex Carbohydrate Transmembrane Transport Polyol Transmembrane Transport Iron Ion Transport Carbohydrate Transport Cellular Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Exocrine Pancreas Development Positive Regulation Of Transport Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Cell Adhesion Transferrin Transport Brush Border Membrane Chemical Homeostasis Protein Folding In Endoplasmic Reticulum
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