LCOR and STX18

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	STX18
Description		ligand dependent nuclear receptor corepressor	syntaxin 18
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane SNARE Complex
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	SNAP Receptor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Membrane Fusion Endoplasmic Reticulum Membrane Organization Positive Regulation Of Organelle Assembly Positive Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Golgi Organization
Pathways			COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Chronic rhinosinusitis ( 33393196) Congenital heart disease ( 23708191)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	6 interacting genes: BNIP1 DISC1 LCOR NSG2 NUPR1 SNCA
Entrez ID		84458	53407
HPRD ID		07609	06923
Ensembl ID		ENSG00000196233	ENSG00000168818
Uniprot IDs		Q96JN0	Q9P2W9
PDB IDs		2COB 6V3X 6V3Y
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Regulation Of Aerobic Respiration Regulation Of Oxidative Phosphorylation Regulation Of Cellular Respiration Kinesin Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Apoptotic Process In Response To Mitochondrial Fragmentation Negative Regulation Of Serotonin Uptake Positive Regulation Of Catabolic Process Transporter Regulator Activity Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Autophagy Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Synaptic Vesicle Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Oxidative Phosphorylation Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Calcium-induced Calcium Release Activity Endoplasmic Reticulum Membrane Fusion Negative Regulation Of Dopamine Metabolic Process Molecular Adaptor Activity Cytoplasmic Vesicle Membrane Positive Regulation Of Inflammatory Response Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Perinuclear Region Of Cytoplasm Negative Regulation Of Catecholamine Metabolic Process Regulation Of Serotonin Uptake Golgi Cis Cisterna Membrane Cell Death Negative Regulation Of Programmed Cell Death Programmed Cell Death Apoptotic Process Negative Regulation Of Apoptotic Process Mitochondrial Outer Membrane Presynapse Regulation Of Chaperone-mediated Autophagy Dopamine Uptake Involved In Synaptic Transmission Response To Iron(II) Ion Calcium Ion Homeostasis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Proteolysis
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