LCOR and FOLH1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	FOLH1
Description		ligand dependent nuclear receptor corepressor	folate hydrolase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	Catalytic Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Dipeptidase Activity Metal Ion Binding Ac-Asp-Glu Binding Tetrahydrofolyl-poly(glutamate) Polymer Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Proteolysis Glutamate Biosynthetic Process Folic Acid-containing Compound Metabolic Process Intestinal Folate Absorption Positive Regulation Of Glutamate Receptor Signaling Pathway
Pathways			Aspartate and asparagine metabolism
Drugs			Capromab pendetide Glutamic acid (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACID DCFBC Spaglumic acid Piflufolastat F 18
Diseases
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Fasting glucose ( 34059833) Feeling fed-up ( 29500382) HDL cholesterol ( 19060911) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 20881960) Intraocular pressure ( 29617998) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748) Systolic blood pressure ( 30578418) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	4 interacting genes: C3orf52 LCOR MTAP RPS3
Entrez ID		84458	2346
HPRD ID		07609	02961
Ensembl ID		ENSG00000196233	ENSG00000086205
Uniprot IDs		Q96JN0	Q04609
PDB IDs		2COB 6V3X 6V3Y	1Z8L 2C6C 2C6G 2C6P 2CIJ 2JBJ 2JBK 2OOT 2OR4 2PVV 2PVW 2XEF 2XEG 2XEI 2XEJ 3BHX 3BI0 3BI1 3BXM 3D7D 3D7F 3D7G 3D7H 3IWW 3RBU 3SJE 3SJF 3SJG 3SJX 4JYW 4JZ0 4LQG 4MCP 4MCQ 4MCR 4MCS 4NGM 4NGN 4NGP 4NGQ 4NGR 4NGS 4NGT 4OC0 4OC1 4OC2 4OC3 4OC4 4OC5 4OME 4P44 4P45 4P4B 4P4D 4P4E 4P4F 4P4I 4P4J 4W9Y 4X3R 5D29 5ELY 5F09 5O5R 5O5T 5O5U 5OF0 6ETY 6EZ9 6F5L 6FE5 6H7Y 6H7Z 6HKJ 6HKZ 6RBC 6RTI 6S1X 6SGP 6SKH 7BFZ 8BO8 8BOL 8BOW
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Nicotinamide Riboside Catabolic Process S-methyl-5-thioadenosine Phosphorylase Activity Positive Regulation Of Base-excision Repair Response To TNF Agonist Oxidized Pyrimidine DNA Binding Purine Ribonucleoside Salvage L-methionine Salvage From Methylthioadenosine L-methionine Salvage Pentosyltransferase Activity 1,4-alpha-oligoglucan Phosphorylase Activity Oxidized Purine DNA Binding Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Deoxyribonuclease Activity Ubiquitin-like Protein Conjugating Enzyme Binding Supercoiled DNA Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Positive Regulation Of Endodeoxyribonuclease Activity Small Ribosomal Subunit RRNA Binding NF-kappaB Complex Regulation Of Base-excision Repair DNA N-glycosylase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Methionine Biosynthetic Process Nucleoside Salvage DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nucleobase-containing Small Molecule Catabolic Process Methionine Metabolic Process Histone Methyltransferase Binding Sulfur Amino Acid Biosynthetic Process Positive Regulation Of T Cell Receptor Signaling Pathway Ubiquitin-specific Protease Binding DNA Endonuclease Activity Protein Kinase A Binding Purine Nucleoside Metabolic Process Small Ribosomal Subunit Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Purine-containing Compound Salvage Positive Regulation Of Microtubule Polymerization Sulfur Amino Acid Metabolic Process Base-excision Repair Cellular Response To Estradiol Stimulus Response To Testosterone Cytosolic Small Ribosomal Subunit Positive Regulation Of Interleukin-2 Production Hsp90 Protein Binding Nuclear Estrogen Receptor Binding Aspartate Family Amino Acid Metabolic Process Regulation Of Activated T Cell Proliferation Negative Regulation Of DNA Repair
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