RAP1GAP and CSNK1G2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		RAP1GAP	CSNK1G2
Gene Name		RAP1 GTPase activating protein	casein kinase 1, gamma 2
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol Membrane	Nucleus Cytosol Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Ras GTPase Binding Protein Homodimerization Activity Rap GTPase Activator Activity	Magnesium Ion Binding Glycoprotein Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Peptide Binding Phosphoprotein Binding
	Biological Process	Signal Transduction Metabolic Process Regulation Of Ras GTPase Activity Positive Regulation Of Rap GTPase Activity Negative Regulation Of Microvillus Assembly	Protein Phosphorylation Sphingolipid Metabolic Process Endocytosis Signal Transduction Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Protein Autophosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Rap1 signalling Adaptive Immune System	disassembly of the destruction complex and recruitment of AXIN to the membrane Sphingolipid metabolism Metabolism of lipids and lipoproteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT Sphingolipid de novo biosynthesis RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Liver enzyme levels ( 18940312)
Protein-Protein Interactions		15 interactors: BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B MLLT4 PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12	13 interactors: APP APPBP2 C2orf44 COL4A3BP DBNDD2 KRTAP10-7 MTA1 NCK1 PER1 PPP1R14A RAP1GAP RUNDC3B SMAD3
Entrez ID		5909	1455
HPRD ID		02609	03738
Ensembl ID		ENSG00000076864	ENSG00000133275
Uniprot IDs		P47736	P78368
PDB IDs		1SRQ 3BRW	2C47
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Catalytic Activity Mitotic Nuclear Envelope Disassembly Regulation Of Synaptic Vesicle Transport Nuclear Envelope Disassembly Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Neurotransmitter Secretion Activation Of MAPKK Activity Nuclear Envelope Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rap GTPase Activity Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Positive Regulation Of Protein Metabolic Process Phosphorylation Regulation Of Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neurotransmitter Secretion Regulation Of Rap GTPase Activity Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Neurotransmitter Transport Regulation Of Rap Protein Signal Transduction Regulation Of Exocytosis Positive Regulation Of MAPK Cascade Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Endothelial Barrier Protein Localization To Chromosome Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Kinase Activity	Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Phosphorylation Posttranscriptional Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Translation Regulation Of Inflammatory Response Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Response To Light Stimulus Positive Regulation Of Transforming Growth Factor Beta3 Production Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Negative Regulation Of Microvillus Assembly Negative Regulation Of Protein Metabolic Process Circadian Regulation Of Gene Expression Response To External Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Circadian Rhythm Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Synaptic Growth At Neuromuscular Junction ER To Golgi Ceramide Transport Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Response To Radiation Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Autoubiquitination Collateral Sprouting In Absence Of Injury Evasion Or Tolerance Of Host Defenses By Virus Positive Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Ceramide Transport Positive Regulation Of Peptidase Activity Positive Regulation Of Metabolic Process
Tagcloud ?		autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1
Tagcloud (Difference) ?		autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1
Tagcloud (Intersection) ?