LCOR and MERTK

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	MERTK
Description		ligand dependent nuclear receptor corepressor	MER proto-oncogene, tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Membrane Receptor Complex
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Spermatogenesis Nervous System Development Cell Migration Platelet Activation Secretion By Cell Substrate Adhesion-dependent Cell Spreading Apoptotic Cell Clearance Lymphocyte Activation Positive Regulation Of Phagocytosis Negative Regulation Of Lymphocyte Activation Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Retina Development In Camera-type Eye Vagina Development Neutrophil Clearance Negative Regulation Of Leukocyte Apoptotic Process
Pathways			Cell surface interactions at the vascular wall
Drugs			2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol Fostamatinib
Diseases			Retinitis pigmentosa (RP)
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Alanine aminotransferase levels ( 34315874 33547301) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Cluster headache ( 34184781) Coronary artery disease ( 33020668 29212778) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 21833088 31604244) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure ( 30224653)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	11 interacting genes: BMPR2 DSCAM ERBB2 GAS6 GRB2 IKBKG LCOR LMO4 NEDD4L TNK2 VAV1
Entrez ID		84458	10461
HPRD ID		07609	05269
Ensembl ID		ENSG00000196233	ENSG00000153208
Uniprot IDs		Q96JN0	Q12866
PDB IDs		2COB 6V3X 6V3Y	2DBJ 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA 5K0K 5K0X 5TC0 5TD2 5U6C 6MEP 7AAX 7AAY 7AAZ 7AB0 7AB1 7AB2 7AVX 7AVY 7AVZ 7AW0 7AW1 7AW2 7AW3 7AW4 7CQE 7DXL 7M5Z 7OAM 7OLS 7OLV 7OLX 7XHY 9BHI 9BHJ 9BHK
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Positive Regulation Of Phosphorylation Grb2-EGFR Complex Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Endocytosis Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Growth Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Import Into Cell Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Activation Regulation Of Axon Extension Involved In Axon Guidance Cellular Developmental Process Schwann Cell Development Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Chemotaxis Intracellular Signaling Cassette Motor Neuron Axon Guidance Positive Regulation Of Developmental Growth Neuron Projection Development Regulation Of Metabolic Process Epidermal Growth Factor Receptor Binding Regulation Of Lymphocyte Activation Neuromuscular Junction Development Positive Regulation Of Axon Extension Regulation Of Chemotaxis Natural Killer Cell Mediated Cytotoxicity Protein Tyrosine Kinase Binding Growth Factor Binding Neuron Projection Guidance Axon Guidance Positive Regulation Of Protein Phosphorylation Natural Killer Cell Mediated Immunity T Cell Costimulation Positive Regulation Of Cellular Component Organization Regulation Of Growth Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Synapse Organization Regulation Of Kinase Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity
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