LCOR and CFH

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	CFH
Description		ligand dependent nuclear receptor corepressor	complement factor H
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle Symbiont Cell Surface Serine-type Endopeptidase Complex
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	Complement Component C3b Binding Protein Binding Heparin Binding Identical Protein Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Regulation Of Complement Activation, Alternative Pathway Innate Immune Response Regulation Of Complement-dependent Cytotoxicity
Pathways			Regulation of Complement cascade
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 32741009 23577725 23536807 23455636 23326517 22694956 21665990 20861866 15761122 20385826) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Aspartate aminotransferase levels ( 33547301) Chronic central serous retinopathy ( 30073298 30480742) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Complement C3 levels ( 33941608) Complement factor H binding to malondialdehyde ( 32321835) Complement factor H levels ( 34260947) Complement factor H-related protein 2 levels ( 34260947) Complement factor H-related protein 3 levels ( 34260947) Complement factor H-related protein 4A levels ( 34260947) Complement factor H-related protein 5 levels ( 34260947) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Fuchs's corneal dystrophy ( 28358029) Liver enzyme levels (alanine transaminase) ( 33972514) Matrix metalloproteinase-8 levels ( 29212897) Meningococcal disease ( 20694013) Neovascular age-related macular degeneration ( 28703135) Nephropathy ( 21399633) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Rheumatic heart disease ( 34106200) Serum C3d:C3 ratio (systemic complement activation) ( 29398083) Sub-foveal choroidal thickness ( 29844195) Systemic lupus erythematosus ( 28714469) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	19 interacting genes: ADM C3 CFHR1 CFI CRP DMP1 DYRK1A EP300 GRB2 ITGAM LCOR PTX3 RSPH1 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16
Entrez ID		84458	3075
HPRD ID		07609	00601
Ensembl ID		ENSG00000196233	ENSG00000000971
Uniprot IDs		Q96JN0	A0A0D9SG88 P08603
PDB IDs		2COB 6V3X 6V3Y	1HAQ 1HCC 1HFH 1HFI 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38 4K12 4ONT 4ZH1 5NBQ 5O32 5O35 5WTB 6ATG 6ZH1 7WKI 7ZJM 9F7I
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Immune Response Immune System Process Defense Response Defense Response To Other Organism Defense Response To Symbiont Opsonization Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Other Organism Immune Effector Process Vertebrate Eye-specific Patterning Response To External Biotic Stimulus Activation Of Immune Response Positive Regulation Of Immune System Process Complement-mediated Synapse Pruning Regionalization Extracellular Space Regulation Of Reactive Oxygen Species Metabolic Process Response To Stress Regulation Of Immune System Process Transcription Corepressor Binding Complement Activation Positive Regulation Of Ossification Complement Component C1q Complex Binding Positive Regulation Of Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Immune Response Innate Immune Response Synapse Pruning Virion Binding Pattern Specification Process Positive Regulation Of Immune Response Complement Component C3b Binding Regulation Of Multicellular Organismal Development Complement Receptor Mediated Signaling Pathway Response To Yeast Immune Response-activating Cell Surface Receptor Signaling Pathway Humoral Immune Response Low-density Lipoprotein Particle Binding Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Inflammatory Response Regulation Of Superoxide Anion Generation
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