LCOR and ATP6V1B2

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		LCOR	ATP6V1B2
Name		ligand dependent nuclear receptor corepressor	ATPase H+ transporting V1 subunit B2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Vacuolar Proton-transporting V-type ATPase, V1 Domain Ruffle Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Microvillus Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase, V1 Domain Melanosome Synapse Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	Nucleotide Binding Protein Binding ATP Binding Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Monoatomic Ion Transport Vacuolar Acidification Regulation Of Macroautophagy ATP Metabolic Process Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		None	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		None	Tiludronic acid Gallium nitrate 4-(2-Aminoethyl)Benzenesulfonyl Fluoride
GWAS		Peak height velocity ( 34047840 ) Simvastatin-induced myopathy ( 31220337 ) Waist circumference ( 28552196 )	Circulating myeloperoxidase levels (serum) ( 23620142 ) Erythrocyte cadmium concentration in never smokers ( 27005419 ) Major depressive disorder (broad) ( 20038947 ) Metabolite levels ( 23823483 ) Persistent hepatitis B virus infection ( 27244555 )
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	3 interacting genes: DSCAM LCOR TCF4
Entrez ID		84458	526
HPRD ID		07609	06088
Ensembl ID		ENSG00000196233	ENSG00000147416
Uniprot IDs		Q96JN0	A0A140VK65 P21281
PDB IDs		2COB 6V3X 6V3Y	6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
GO Terms Enriched among Interactors		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Post-embryonic Retina Morphogenesis In Camera-type Eye Positive Regulation Of Axon Extension Involved In Axon Guidance Netrin Receptor Binding TFIIB-class Transcription Factor Binding Beta-catenin-TCF7L2 Complex Netrin-activated Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Dendrite Self-avoidance Camera-type Eye Photoreceptor Cell Differentiation Eye Photoreceptor Cell Differentiation Dendritic Spine Development Nervous System Development Photoreceptor Cell Differentiation Beta-catenin-TCF Complex Histone Methyltransferase Binding Ubiquitin-specific Protease Binding