LCOR and MAP3K10

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	MAP3K10
Description		ligand dependent nuclear receptor corepressor	mitogen-activated protein kinase kinase kinase 10
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	Nucleotide Binding Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Birth weight ( 31043758) Resting heart rate ( 27798624)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 LCOR MAP2K4 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB1 RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE
Entrez ID		84458	4294
HPRD ID		07609	02533
Ensembl ID		ENSG00000196233	ENSG00000130758
Uniprot IDs		Q96JN0	Q02779
PDB IDs		2COB 6V3X 6V3Y	2RF0
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	MAPK Cascade Kinesin II Complex Protein Phosphatase Binding Cytoplasm Vesicle-mediated Transport Cytoskeleton-dependent Intracellular Transport Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction Dendrite Cytoplasm Signal Transduction Intracellular Signaling Cassette Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Cytosol Organelle Transport Along Microtubule Regulation Of Multicellular Organismal Process Transport Along Microtubule Nucleotide Binding Anterograde Dendritic Transport Regulation Of Cell Communication Regulation Of Signaling Endocytosis Extracellular Exosome Protein Kinase Binding Intracellular Protein Localization Cellular Localization Vesicle Transport Along Microtubule Kinesin Complex MAP-kinase Scaffold Activity Membrane Invagination Receptor Localization To Synapse Regulation Of Transport Regulation Of Immune System Process Microtubule Microtubule-based Transport MAP Kinase Activity Positive Regulation Of Cellular Component Organization Vesicle Cytoskeletal Trafficking Postsynapse Dendritic Transport Negative Regulation Of Signal Transduction JNK Cascade Cell Surface Receptor Signaling Pathway Mitotic Spindle Intracellular Transport Regulation Of Vesicle-mediated Transport Plus-end-directed Microtubule Motor Activity Microtubule Binding Microtubule Cytoskeleton Positive Regulation Of Leukocyte Migration
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