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POLR1B and GIT2
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
POLR1B
GIT2
Gene Name
polymerase (RNA) I polypeptide B, 128kDa
G protein-coupled receptor kinase interacting ArfGAP 2
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Nucleolus
DNA-directed RNA Polymerase I Complex
Cytoplasm
Nucleoplasm
Focal Adhesion
Molecular Function
RNA Polymerase I Activity
DNA Binding
Protein Binding
Ribonucleoside Binding
Metal Ion Binding
Protein Binding
ARF GTPase Activator Activity
Zinc Ion Binding
Biological Process
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Embryo Implantation
RRNA Transcription
Gene Expression
Nucleologenesis
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Regulation Of ARF GTPase Activity
Positive Regulation Of GTPase Activity
Behavioral Response To Pain
Pathways
NoRC negatively regulates rRNA expression
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription
RNA Polymerase I Transcription Termination
RNA Polymerase I Promoter Escape
RNA Polymerase I Promoter Clearance
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Metabolic syndrome (
20694148
)
Metabolite levels (MHPG) (
23319000
)
Protein-Protein Interactions
14 interactors:
AKT2
CCND1
EIF3L
ESR1
GIT2
HDAC6
LDB1
LZTR1
MED20
NFKBIB
POLR1E
RPL37
RRN3
ZNF207
44 interactors:
ACTG1
ACTN1
ADRBK1
ARHGEF7
ATF5
C4BPA
CALCOCO2
CORO1A
E2F2
EDC4
GCH1
GIT1
GUSB
HGD
HNRNPUL1
IKBKG
KCTD5
KRT18
LMNB1
MVP
NFKBIB
NME2
PAK1
PAK3
PCLO
POLR1B
PROX1
PXN
QPRT
RCVRN
RUFY1
RUSC2
SAFB2
SH3GLB2
SMAD3
SPOP
TGFB1I1
TNFAIP3
TNIP1
TRAF1
TSN
UBQLN1
USHBP1
YWHAG
Entrez ID
84172
9815
HPRD ID
06852
09779
Ensembl ID
ENSG00000125630
ENSG00000139436
Uniprot IDs
Q9H9Y6
F8VXI9
Q14161
Q6FI58
PDB IDs
Enriched GO Terms of Interacting Partners
?
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Gene Expression
RNA Biosynthetic Process
Gene Expression
Regulation Of Metabolic Process
Biosynthetic Process
DNA-templated Transcription, Initiation
Transcription, DNA-templated
RNA Metabolic Process
Mammary Gland Epithelium Development
Mammary Gland Epithelial Cell Proliferation
Transcription Initiation From RNA Polymerase I Promoter
Mammary Gland Development
Transcription From RNA Polymerase I Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromosome Organization
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Mammary Gland Lobule Development
Mammary Gland Alveolus Development
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Chromatin Organization
Histone H3-K4 Acetylation
Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery
Hsp90 Deacetylation
Negative Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Regulation Of Oxidoreductase Activity
Positive Regulation Of Type I Interferon Production
Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript
Positive Regulation Of Hemoglobin Biosynthetic Process
Polyubiquitinated Misfolded Protein Transport
Epithelial Cell Proliferation
Regulation Of Cell Cycle Arrest
Positive Regulation Of Metabolic Process
Re-entry Into Mitotic Cell Cycle
Prostate Epithelial Cord Elongation
Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter
Cellular Response To Topologically Incorrect Protein
Regulation Of Type I Interferon Production
Regulation Of Apoptotic Process
Regulation Of Cell Death
Ephrin Receptor Signaling Pathway
Innate Immune Response
Response To External Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stimulus
Apoptotic Process
Regulation Of Signaling
Programmed Cell Death
Regulation Of Signal Transduction
Immune System Process
Immune Response
Regulation Of Immune System Process
Cell Death
Regulation Of Metabolic Process
Death
Positive Regulation Of Immune Response
Defense Response
Signal Transduction
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Adherens Junction Organization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Immune System Process
Focal Adhesion Assembly
Positive Regulation Of Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Phosphorus Metabolic Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-cell Junction Organization
Regulation Of Protein Kinase Activity
Positive Regulation Of Catalytic Activity
Signaling
Regulation Of Kinase Activity
Cellular Component Assembly
Cell Communication
Regulation Of Phosphorylation
Adherens Junction Assembly
Regulation Of Protein Phosphorylation
Regulation Of Cellular Component Organization
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Cell Development
Cell-substrate Junction Assembly
Activation Of MAPK Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Response To Stress
Activation Of Innate Immune Response
Cell Surface Receptor Signaling Pathway
Tagcloud
?
ancient
autophosphorylation
coordinates
deregulated
dimerization
exchange
gef
git1
gtpase
guanine
hippo
hpo
interacting
mammals
melanogaster
metazoan
oligomeric
originally
pak
pix
polarity
proteomics
rho
rtgef
salvador
scaffold
sterile
undefined
Tagcloud (Difference)
?
ancient
autophosphorylation
coordinates
deregulated
dimerization
exchange
gef
git1
gtpase
guanine
hippo
hpo
interacting
mammals
melanogaster
metazoan
oligomeric
originally
pak
pix
polarity
proteomics
rho
rtgef
salvador
scaffold
sterile
undefined
Tagcloud (Intersection)
?