POLR1B and RRN3

Number of citations of the paper that reports this interaction (PMID 15004009)
81

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		POLR1B	RRN3
Gene Name		polymerase (RNA) I polypeptide B, 128kDa	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus DNA-directed RNA Polymerase I Complex Cytoplasm	Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase I Activity DNA Binding Protein Binding Ribonucleoside Binding Metal Ion Binding	RNA Polymerase Binding
	Biological Process	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Embryo Implantation RRNA Transcription Gene Expression Nucleologenesis Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	In Utero Embryonic Development Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Cell Proliferation Gene Expression Ribosome Biogenesis Positive Regulation Of Transcription, DNA-templated Homeostasis Of Number Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription, Initiation
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207	10 interactors: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C
Entrez ID		84172	54700
HPRD ID		06852	12004
Ensembl ID		ENSG00000125630	ENSG00000085721
Uniprot IDs		Q9H9Y6	F5H148 Q9NYV6
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Biosynthetic Process Gene Expression Regulation Of Metabolic Process Biosynthetic Process DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Metabolic Process Mammary Gland Epithelium Development Mammary Gland Epithelial Cell Proliferation Transcription Initiation From RNA Polymerase I Promoter Mammary Gland Development Transcription From RNA Polymerase I Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Organization Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Organization Histone H3-K4 Acetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Hsp90 Deacetylation Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Oxidoreductase Activity Positive Regulation Of Type I Interferon Production Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Positive Regulation Of Hemoglobin Biosynthetic Process Polyubiquitinated Misfolded Protein Transport Epithelial Cell Proliferation Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Re-entry Into Mitotic Cell Cycle Prostate Epithelial Cord Elongation Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Cellular Response To Topologically Incorrect Protein Regulation Of Type I Interferon Production	Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Chromatin Silencing At RDNA Chromatin Silencing Gene Silencing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RRNA Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Expression Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Nucleologenesis RNA Metabolic Process RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of DNA-dependent DNA Replication Initiation G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Mitotic Cell Cycle Process Post-embryonic Hemopoiesis Nucleolus Organization Cellular Metabolic Process Mitotic Cell Cycle Regulation Of DNA-dependent DNA Replication Initiation Mitotic Nuclear Envelope Reassembly Glomerular Visceral Epithelial Cell Development Regulation Of Tight Junction Assembly Metabolic Process Nuclear Envelope Reassembly
Tagcloud ?			architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking network orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 subunits tata tbp tfiib upstream validated
Tagcloud (Difference) ?			architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking network orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 subunits tata tbp tfiib upstream validated
Tagcloud (Intersection) ?