POLR1B and RRN3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		POLR1B	RRN3
Description		RNA polymerase I subunit B	RNA polymerase I transcription factor RRN3
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Cytosol	Nucleus Nucleoplasm Nucleolus
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Ribonucleoside Binding 5'-3' RNA Polymerase Activity Metal Ion Binding DNA/RNA Hybrid Binding	RNA Polymerase I Core Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Protein Binding RNA Polymerase Binding
	Biological Process	DNA-templated Transcription Embryo Implantation RRNA Transcription Neural Crest Formation Nucleologenesis	RNA Polymerase I Preinitiation Complex Assembly In Utero Embryonic Development DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Ribosome Biogenesis Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Homeostasis Of Number Of Cells Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription Initiation
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape
Drugs
Diseases
GWAS			Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fruit consumption ( 32066663) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Serum metabolite levels ( 33031748) Triglyceride levels ( 32154731)
Interacting Genes		14 interacting genes: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207	10 interacting genes: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C
Entrez ID		84172	54700
HPRD ID		06852	12004
Ensembl ID		ENSG00000125630	ENSG00000085721
Uniprot IDs		B7Z1W6 Q9H9Y6	B7ZB55 F5H148 Q9NYV6
PDB IDs		7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43	7OBA
Enriched GO Terms of Interacting Partners?		Macromolecule Biosynthetic Process Transcription Preinitiation Complex Assembly Nucleoplasm DNA-templated Transcription Protein-DNA Complex Assembly Transcription Initiation At RNA Polymerase I Promoter RNA Polymerase I Preinitiation Complex Assembly Nucleobase-containing Compound Biosynthetic Process Regulation Of Intracellular Signal Transduction Protein-containing Complex Organization Mammary Gland Epithelial Cell Proliferation Response To Corticosterone Mammary Gland Alveolus Development Macromolecule Metabolic Process Cellular Component Assembly Enzyme Binding Protein-containing Complex Protein-containing Complex Assembly Response To Mineralocorticoid RNA Metabolic Process Fibroblast Proliferation Cellular Response To High Light Intensity RNA Polymerase II Preinitiation Complex Assembly Transcription Corepressor Binding Spindle Matrix Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation RNA Polymerase I General Transcription Initiation Factor Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Signal Transduction Cell Leading Edge Response To High Light Intensity Response To Hormone Retinal Rod Cell Apoptotic Process Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Response To Estrogen Transcription By RNA Polymerase II Transcription Coactivator Activity Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity DNA-templated Transcription Initiation Cellular Response To Hormone Stimulus Positive Regulation Of Cap-dependent Translational Initiation	Transcription By RNA Polymerase I RNA Polymerase Transcription Factor SL1 Complex DNA-templated Transcription Nucleolus RRNA Transcription Nucleoplasm Cyclin E1-CDK2 Complex RNA Polymerase I Transcription Regulator Complex Nucleolar Large RRNA Transcription By RNA Polymerase I Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process DNA/RNA Hybrid Binding 5'-3' RNA Polymerase Activity RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Complex Nucleic Acid Metabolic Process RNA Metabolic Process Macromolecule Metabolic Process Fibrillar Center Nucleobase-containing Compound Metabolic Process DNA-directed RNA Polymerase Activity DNA-directed RNA Polymerase Complex Cyclin-dependent Protein Kinase Holoenzyme Complex RRNA Metabolic Process Transcription Preinitiation Complex Assembly RNA Polymerase I Core Factor Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Negative Regulation Of Protein Localization To Nucleolus Nucleologenesis Nucleotidyltransferase Activity Telomere Maintenance Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Ribonucleoside Binding X Chromosome Telomere Organization Stereocilium Membrane RNA Polymerase I General Transcription Initiation Factor Activity Viral Translational Termination-reinitiation Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity
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