POLR1B and LZTR1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		POLR1B	LZTR1
Description		RNA polymerase I subunit B	leucine zipper like post translational regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Cytosol	Endosome Golgi Apparatus Endomembrane System Membrane Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Ribonucleoside Binding 5'-3' RNA Polymerase Activity Metal Ion Binding DNA/RNA Hybrid Binding	Protein Binding Small GTPase Binding
	Biological Process	DNA-templated Transcription Embryo Implantation RRNA Transcription Neural Crest Formation Nucleologenesis	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207	54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		84172	8216
HPRD ID		06852	08992
Ensembl ID		ENSG00000125630	ENSG00000099949
Uniprot IDs		B7Z1W6 Q9H9Y6	A0A384NL67 Q8N653
PDB IDs		7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43
Enriched GO Terms of Interacting Partners?		Macromolecule Biosynthetic Process Transcription Preinitiation Complex Assembly Nucleoplasm DNA-templated Transcription Protein-DNA Complex Assembly Transcription Initiation At RNA Polymerase I Promoter RNA Polymerase I Preinitiation Complex Assembly Nucleobase-containing Compound Biosynthetic Process Regulation Of Intracellular Signal Transduction Protein-containing Complex Organization Mammary Gland Epithelial Cell Proliferation Response To Corticosterone Mammary Gland Alveolus Development Macromolecule Metabolic Process Cellular Component Assembly Enzyme Binding Protein-containing Complex Protein-containing Complex Assembly Response To Mineralocorticoid RNA Metabolic Process Fibroblast Proliferation Cellular Response To High Light Intensity RNA Polymerase II Preinitiation Complex Assembly Transcription Corepressor Binding Spindle Matrix Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation RNA Polymerase I General Transcription Initiation Factor Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Signal Transduction Cell Leading Edge Response To High Light Intensity Response To Hormone Retinal Rod Cell Apoptotic Process Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Response To Estrogen Transcription By RNA Polymerase II Transcription Coactivator Activity Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity DNA-templated Transcription Initiation Cellular Response To Hormone Stimulus Positive Regulation Of Cap-dependent Translational Initiation	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nuclear Body Nucleic Acid Metabolic Process Nucleolus Ribonucleoside Binding Transcription Coactivator Activity Chromatin Organization RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex DNA-directed RNA Polymerase Activity Regulation Of DNA-templated Transcription Initiation Chromo Shadow Domain Binding Chromatin Remodeling 5'-3' RNA Polymerase Activity
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