POLR1B and POLR1E

Number of citations of the paper that reports this interaction (PMID 9254723)
18

Data Source:
HPRD (in vitro)

		POLR1B	POLR1E
Gene Name		polymerase (RNA) I polypeptide B, 128kDa	polymerase (RNA) I polypeptide E, 53kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus DNA-directed RNA Polymerase I Complex Cytoplasm	Nucleus Nucleoplasm Nucleolus DNA-directed RNA Polymerase I Complex
	Molecular Function	RNA Polymerase I Activity DNA Binding Protein Binding Ribonucleoside Binding Metal Ion Binding	RNA Polymerase I Activity RNA Polymerase I Transcription Factor Binding DNA Binding
	Biological Process	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Embryo Implantation RRNA Transcription Gene Expression Nucleologenesis Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription RRNA Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression	NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207	7 interactors: CD3EAP NFKBIB POLR1A POLR1B POLR1C TAF1C UBTF
Entrez ID		84172	64425
HPRD ID		06852	15096
Ensembl ID		ENSG00000125630	ENSG00000137054
Uniprot IDs		Q9H9Y6	Q9GZS1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Biosynthetic Process Gene Expression Regulation Of Metabolic Process Biosynthetic Process DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Metabolic Process Mammary Gland Epithelium Development Mammary Gland Epithelial Cell Proliferation Transcription Initiation From RNA Polymerase I Promoter Mammary Gland Development Transcription From RNA Polymerase I Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Organization Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Organization Histone H3-K4 Acetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Hsp90 Deacetylation Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Oxidoreductase Activity Positive Regulation Of Type I Interferon Production Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Positive Regulation Of Hemoglobin Biosynthetic Process Polyubiquitinated Misfolded Protein Transport Epithelial Cell Proliferation Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Re-entry Into Mitotic Cell Cycle Prostate Epithelial Cord Elongation Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Cellular Response To Topologically Incorrect Protein Regulation Of Type I Interferon Production	Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RRNA Transcription Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Type I Interferon Production Nucleologenesis Regulation Of Metabolic Process Regulation Of Type I Interferon Production Nucleolus Organization Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Cytokine Production Chromatin Silencing At RDNA Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Cytokine Production Chromatin Silencing Transcription From RNA Polymerase III Promoter Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response
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