POLR1B and ZNF207

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		POLR1B	ZNF207
Gene Name		polymerase (RNA) I polypeptide B, 128kDa	zinc finger protein 207
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus DNA-directed RNA Polymerase I Complex Cytoplasm	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleolus Microtubule
	Molecular Function	RNA Polymerase I Activity DNA Binding Protein Binding Ribonucleoside Binding Metal Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Microtubule Binding Heparin Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Embryo Implantation RRNA Transcription Gene Expression Nucleologenesis Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Mitotic Sister Chromatid Segregation Regulation Of Transcription, DNA-templated Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Protein Stabilization Cell Division Regulation Of Chromosome Segregation
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AKT2 CCND1 EIF3L ESR1 GIT2 HDAC6 LDB1 LZTR1 MED20 NFKBIB POLR1E RPL37 RRN3 ZNF207	8 interactors: BUB3 ERBB3 HNRNPM HNRNPUL1 MAP2K2 POLR1B WBP4 WDR77
Entrez ID		84172	7756
HPRD ID		06852	04576
Ensembl ID		ENSG00000125630	ENSG00000010244
Uniprot IDs		Q9H9Y6	O43670
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Biosynthetic Process Gene Expression Regulation Of Metabolic Process Biosynthetic Process DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Metabolic Process Mammary Gland Epithelium Development Mammary Gland Epithelial Cell Proliferation Transcription Initiation From RNA Polymerase I Promoter Mammary Gland Development Transcription From RNA Polymerase I Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Organization Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Organization Histone H3-K4 Acetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Hsp90 Deacetylation Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Oxidoreductase Activity Positive Regulation Of Type I Interferon Production Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Positive Regulation Of Hemoglobin Biosynthetic Process Polyubiquitinated Misfolded Protein Transport Epithelial Cell Proliferation Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Re-entry Into Mitotic Cell Cycle Prostate Epithelial Cord Elongation Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Cellular Response To Topologically Incorrect Protein Regulation Of Type I Interferon Production	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Nucleologenesis Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Nucleolus Organization Neurotrophin TRK Receptor Signaling Pathway Peptidyl-serine Autophosphorylation Neurotrophin Signaling Pathway Gene Expression Fc-epsilon Receptor Signaling Pathway Regulation Of Golgi Organization Fc Receptor Signaling Pathway Attachment Of Spindle Microtubules To Kinetochore Peptidyl-tyrosine Phosphorylation Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
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