SET and TREX1

Number of citations of the paper that reports this interaction (PMID 16818237)
46

Data Source:
BioGRID (biochemical, pull down)

		SET	TREX1
Gene Name		SET nuclear proto-oncogene	three prime repair exonuclease 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Protein Complex Perinuclear Region Of Cytoplasm	Nucleus Nuclear Envelope Nucleolus Endoplasmic Reticulum Membrane Cytosol
	Molecular Function	DNA Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity Histone Binding	Double-stranded DNA Binding Single-stranded DNA Binding 3'-5'-exodeoxyribonuclease Activity 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle DNA Replication Nucleosome Assembly Nucleosome Disassembly Nucleocytoplasmic Transport Gene Expression Negative Regulation Of Histone Acetylation Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Catalytic Activity	DNA Catabolic Process, Exonucleolytic DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Recombination Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Interferon-beta Innate Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Mitotic Prophase Condensation of Prophase Chromosomes HuR stabilizes mRNA Cell Cycle, Mitotic M Phase	Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses Regulation by TREX1 IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		51 interactors: ANP32A APEX1 APP CALM1 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 EP300 FAM111B FOS GZMA GZMK HDAC1 HIST1H2BA HIST1H3A HIST2H4A HIST3H3 HIST4H4 HMGB2 IRF1 JUNB KLF5 KMT2A MDM2 MEOX2 MTERF1 NME1 NUCB1 NUPR1 PIK3CG PPP2CA PPP2R1B PRKAR1A PTMA RAC1 SDCBP SETBP1 SGOL1 TAF1A TERF1 TERF2 TERF2IP THAP7 TP53 TREX1 UCHL5	13 interactors: ATM ATR IFT20 KRTAP10-7 MCM7 MSH2 NBN PRKDC RIBC2 RPA1 SET UBQLN1 VKORC1
Entrez ID		6418	11277
HPRD ID		09023	09423
Ensembl ID		ENSG00000119335	ENSG00000213689
Uniprot IDs		Q01105 Q5VXV3	Q5TZT0 Q9NSU2
PDB IDs		2E50
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Metabolic Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Transcription, DNA-templated Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Telomere Maintenance Developmental Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Apoptotic Process Programmed Cell Death Regulation Of Cell Cycle Process Cellular Metabolic Process DNA Replication-dependent Nucleosome Assembly Cell Cycle Transcription, DNA-templated Organelle Organization Regulation Of Gene Expression, Epigenetic Blood Coagulation Positive Regulation Of Protein Metabolic Process Chromatin Assembly RNA Biosynthetic Process Cellular Component Assembly Hemostasis Chromatin Organization Negative Regulation Of Cell Cycle Anatomical Structure Development Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Negative Regulation Of Transcription, DNA-templated Response To Growth Factor Negative Regulation Of Gene Expression	Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination DNA Metabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Cell Cycle Cellular Response To DNA Damage Stimulus Telomere Maintenance Cell Cycle Checkpoint Cellular Response To Stress Chromosome Organization Mitotic DNA Damage Checkpoint Cell Cycle Process DNA Repair Mitotic DNA Integrity Checkpoint Response To Abiotic Stimulus Mitotic Cell Cycle Process Regulation Of Cellular Response To Heat Response To Ionizing Radiation Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins B Cell Activation Organelle Organization Mitotic Cell Cycle Checkpoint Response To Radiation Intrinsic Apoptotic Signaling Pathway Response To Stress Response To Gamma Radiation Meiotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Immunoglobulin Production Cellular Response To Heat DNA Replication Immune System Development Replicative Senescence Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Signal Transduction In Response To DNA Damage B Cell Differentiation Apoptotic Signaling Pathway Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Heat Signal Transduction By P53 Class Mediator Peptidyl-serine Phosphorylation Lymphocyte Activation Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle
Tagcloud ?		already assessing cognition cognitive cogs computation correlating costs cps deterioration easy estimate exam global inasmuch mds meaningful mental mini minimum msd quite residents scale scales simple slightly straightforward substantially utility	295insa 885del ags aicardi boundaries boy calcification chilblain counseling dystonia ganglia goutieres hyperintense hypointense limbs microcephaly nonsense performances posture proband references reviewing rnaseh2b sister summarized t1w t2w torsion weighted
Tagcloud (Difference) ?		already assessing cognition cognitive cogs computation correlating costs cps deterioration easy estimate exam global inasmuch mds meaningful mental mini minimum msd quite residents scale scales simple slightly straightforward substantially utility	295insa 885del ags aicardi boundaries boy calcification chilblain counseling dystonia ganglia goutieres hyperintense hypointense limbs microcephaly nonsense performances posture proband references reviewing rnaseh2b sister summarized t1w t2w torsion weighted
Tagcloud (Intersection) ?