SET and TEX35

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SET	TEX35
Description		SET nuclear proto-oncogene	testis expressed 35
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm	Nucleus Microtubule Cytoskeleton
	Molecular Function	DNA Binding Chromatin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Histone Binding	Protein Binding
	Biological Process	DNA Replication Nucleosome Assembly Nucleosome Disassembly Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription
Pathways		Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS		Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Red cell distribution width ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		69 interacting genes: ANP32A APEX1 APP CALM1 CDCA8 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 ENO1 EP300 ESR1 FAM111B FBXO7 FOS FOXO1 GZMA GZMK H1-1 H2BC1 H3-3A H3-4 H4C14 H4C16 HMGB2 IRF1 JUNB KLF5 KMT2A LGMN MDM2 MEOX2 MTERF1 NEDD8 NME1 NUCB1 NUPR1 PAX6 PIK3CG PPP2CA PPP2R1B PRKAR1A PTEN PTMA RAC1 SDCBP SETBP1 SGO1 SGO2 TAF1A TERF1 TERF2 TERF2IP TEX35 THAP7 TLE5 TREX1 TRIM55 TRIM63 UBE3A UCHL5 XRCC6 ZNF17 ZNF438 ZNF85	10 interacting genes: BRAP C14orf119 KDM1A NUTF2 PRMT6 SET SUV39H1 UBL5 VHL WASHC3
Entrez ID		6418	84066
HPRD ID		09023	13169
Ensembl ID		ENSG00000119335	ENSG00000240021
Uniprot IDs		A0A8J8YYJ1 Q01105 Q5VXV3	Q5T0J7
PDB IDs		2E50 7MTO
Enriched GO Terms of Interacting Partners?		Nucleus DNA Binding Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Telomere Organization Chromosome, Telomeric Region Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Organization Regulation Of Multicellular Organismal Process Chromatin Remodeling Regulation Of Gene Expression Regulation Of Phosphorus Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Double-stranded Telomeric DNA Binding Nuclear Telomere Cap Complex Regulation Of Purine Nucleotide Metabolic Process Nucleosome Organization Regulation Of Developmental Process Protein-DNA Complex Assembly Regulation Of Glycolytic Process Regulation Of Cell Cycle Regulation Of Carbohydrate Catabolic Process Protein-containing Complex Negative Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of Programmed Cell Death Protein-DNA Complex Double-stranded DNA Binding Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process	Chromatin Binding Histone H3 Methyltransferase Activity Nucleoplasm Histone Methyltransferase Activity Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H2AR3 Methyltransferase Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II ENoSc Complex Protein Localization To Nuclear Pore Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity
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