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SET and PRKAR1A
Number of citations of the paper that reports this interaction (PubMedID
20195357
)
57
Data Source:
BioGRID
(pull down)
SET
PRKAR1A
Description
SET nuclear proto-oncogene
protein kinase cAMP-dependent type I regulatory subunit alpha
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Lipid Droplet
Cytosol
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Immunological Synapse
Cytoplasm
Multivesicular Body
Centrosome
Cytosol
Plasma Membrane
Axoneme
CAMP-dependent Protein Kinase Complex
Membrane
Nucleotide-activated Protein Kinase Complex
Neuromuscular Junction
Protein-containing Complex
Plasma Membrane Raft
Synapse
Ciliary Base
Glutamatergic Synapse
Sperm Head-tail Coupling Apparatus
Molecular Function
DNA Binding
Chromatin Binding
Protein Phosphatase Inhibitor Activity
Protein Binding
Protein Phosphatase Regulator Activity
Histone Binding
Nucleotide Binding
CAMP-dependent Protein Kinase Inhibitor Activity
Protein Binding
CAMP-dependent Protein Kinase Regulator Activity
Protein Domain Specific Binding
CAMP Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Catalytic Subunit Binding
Biological Process
DNA Replication
Nucleosome Assembly
Nucleosome Disassembly
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Mesoderm Formation
Regulation Of Transcription By RNA Polymerase II
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Heart Development
Negative Regulation Of Gene Expression
Positive Regulation Of Insulin Secretion
Intracellular Signal Transduction
Sarcomere Organization
Negative Regulation Of Activated T Cell Proliferation
Cardiac Muscle Cell Proliferation
Cellular Response To Glucagon Stimulus
Negative Regulation Of CAMP/PKA Signal Transduction
Pathways
Condensation of Prophase Chromosomes
HuR (ELAVL1) binds and stabilizes mRNA
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
CREB1 phosphorylation through the activation of Adenylate Cyclase
Hedgehog 'off' state
GPER1 signaling
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Factors involved in megakaryocyte development and platelet production
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
(Rp)-cAMPS
Cyclic GMP
Cyclic adenosine monophosphate
GEM-231
Diseases
Pigmented micronodular adrenocortical disease (PPNAD)
GWAS
Axial length (
24144296
)
Body mass index (
26426971
)
Eating disorders (purging via substances) (
23568457
)
Body size at age 10 (
32376654
)
Coronary artery disease (
33020668
)
Estimated glomerular filtration rate (
31152163
)
Intake of total sugars (
31005972
)
Serum alkaline phosphatase levels (
33547301
)
Interacting Genes
69 interacting genes:
ANP32A
APEX1
APP
CALM1
CDCA8
CDK5
CDK5R1
CDKN1A
CHAF1A
CHRM2
CHRM3
ELAVL1
ELF4
ENO1
EP300
ESR1
FAM111B
FBXO7
FOS
FOXO1
GZMA
GZMK
H1-1
H2BC1
H3-3A
H3-4
H4C14
H4C16
HMGB2
IRF1
JUNB
KLF5
KMT2A
LGMN
MDM2
MEOX2
MTERF1
NEDD8
NME1
NUCB1
NUPR1
PAX6
PIK3CG
PPP2CA
PPP2R1B
PRKAR1A
PTEN
PTMA
RAC1
SDCBP
SETBP1
SGO1
SGO2
TAF1A
TERF1
TERF2
TERF2IP
TEX35
THAP7
TLE5
TREX1
TRIM55
TRIM63
UBE3A
UCHL5
XRCC6
ZNF17
ZNF438
ZNF85
55 interacting genes:
AKAP1
AKAP10
AKAP11
AKAP19
AKAP4
AKAP5
AKAP7
AKT1
ARFGEF2
BAHD1
BTG3
CAPN11
CBS
CCNE1
CDK2
CDK4
CSTPP1
DSCR4
DSCR9
DTX1
EGFR
FAM153B
GRB2
HIVEP1
HLA-A
ITGA4
MAP1A
MAP1B
MAPK6
MYO7A
NELL2
OGT
PATZ1
PJA2
PLEKHF2
PRKACA
PRKAR1B
PRKX
PRPF40A
PSMG1
PYCARD
RAF1
RFC2
RSPH3
SET
SETD7
SLC2A4
SMAD2
SNCA
SPART
TAB1
WDCP
WNK1
YWHAZ
ZBED1
Entrez ID
6418
5573
HPRD ID
09023
01786
Ensembl ID
ENSG00000119335
ENSG00000108946
Uniprot IDs
A0A8J8YYJ1
Q01105
Q5VXV3
B2R5T5
P10644
PDB IDs
2E50
7MTO
5KJX
5KJY
5KJZ
Enriched GO Terms of Interacting Partners
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Nucleus
DNA Binding
Chromosome Organization
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Negative Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromosome
Telomere Organization
Chromosome, Telomeric Region
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Chromatin Organization
Regulation Of Multicellular Organismal Process
Chromatin Remodeling
Regulation Of Gene Expression
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Nucleosome Assembly
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of ATP Metabolic Process
Double-stranded Telomeric DNA Binding
Nuclear Telomere Cap Complex
Regulation Of Purine Nucleotide Metabolic Process
Nucleosome Organization
Regulation Of Developmental Process
Protein-DNA Complex Assembly
Regulation Of Glycolytic Process
Regulation Of Cell Cycle
Regulation Of Carbohydrate Catabolic Process
Protein-containing Complex
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Chromatin
Regulation Of Programmed Cell Death
Protein-DNA Complex
Double-stranded DNA Binding
Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Protein Kinase A Regulatory Subunit Binding
CAMP-dependent Protein Kinase Complex
Protein Kinase A Binding
Protein Phosphorylation
Cytosol
Phosphorylation
Protein-containing Complex
Ubiquitin Protein Ligase Binding
Cytoplasm
Peptidyl-serine Phosphorylation
Regulation Of Protein Localization To Cell Periphery
Protein Serine Kinase Activity
Intracellular Signal Transduction
Regulation Of Biological Quality
Signal Transduction
Kinase Activity
Protein Kinase Activity
Cyclin E1-CDK2 Complex
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Serine/threonine Kinase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
TORC1 Signaling
Regulation Of Lymphocyte Migration
Intracellular Signaling Cassette
Postsynapse
Cellular Response To Oxygen-containing Compound
Protein Kinase Binding
Intracellular Protein Localization
Protein Domain Specific Binding
Cell Surface Receptor Signaling Pathway
Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Protein Localization To Cell Periphery
ERBB Signaling Pathway
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
CAMP-dependent Protein Kinase Activity
Establishment Of Protein Localization
TOR Signaling
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Negative Regulation Of Catabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of T Cell Migration
Odontoblast Differentiation
Regulation Of Protein Kinase A Signaling
Organelle Organization
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Protein Localization To Membrane
Enzyme Binding
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Tagcloud (Intersection)
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