SET and SGO2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SET	SGO2
Description		SET nuclear proto-oncogene	shugoshin 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body Mitotic Cohesin Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Histone Binding	Protein Binding
	Biological Process	DNA Replication Nucleosome Assembly Nucleosome Disassembly Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription	Chromosome Segregation Meiotic Sister Chromatid Cohesion Cell Division Meiotic Cell Cycle
Pathways		Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)
Interacting Genes		69 interacting genes: ANP32A APEX1 APP CALM1 CDCA8 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 ENO1 EP300 ESR1 FAM111B FBXO7 FOS FOXO1 GZMA GZMK H1-1 H2BC1 H3-3A H3-4 H4C14 H4C16 HMGB2 IRF1 JUNB KLF5 KMT2A LGMN MDM2 MEOX2 MTERF1 NEDD8 NME1 NUCB1 NUPR1 PAX6 PIK3CG PPP2CA PPP2R1B PRKAR1A PTEN PTMA RAC1 SDCBP SETBP1 SGO1 SGO2 TAF1A TERF1 TERF2 TERF2IP TEX35 THAP7 TLE5 TREX1 TRIM55 TRIM63 UBE3A UCHL5 XRCC6 ZNF17 ZNF438 ZNF85	7 interacting genes: CDCA8 EXOSC8 PPP2CA PPP2R1A PPP2R1B SET SLAIN2
Entrez ID		6418	151246
HPRD ID		09023	11555
Ensembl ID		ENSG00000119335	ENSG00000163535
Uniprot IDs		A0A8J8YYJ1 Q01105 Q5VXV3	B7Z7S9 Q562F6
PDB IDs		2E50 7MTO
Enriched GO Terms of Interacting Partners?		Nucleus DNA Binding Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Telomere Organization Chromosome, Telomeric Region Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Organization Regulation Of Multicellular Organismal Process Chromatin Remodeling Regulation Of Gene Expression Regulation Of Phosphorus Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Double-stranded Telomeric DNA Binding Nuclear Telomere Cap Complex Regulation Of Purine Nucleotide Metabolic Process Nucleosome Organization Regulation Of Developmental Process Protein-DNA Complex Assembly Regulation Of Glycolytic Process Regulation Of Cell Cycle Regulation Of Carbohydrate Catabolic Process Protein-containing Complex Negative Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of Programmed Cell Death Protein-DNA Complex Double-stranded DNA Binding Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process	Protein Phosphatase Type 2A Complex RNA Surveillance Nuclear RNA Surveillance Protein Phosphatase Regulator Activity Meiotic Sister Chromatid Cohesion, Centromeric Microtubule Cytoskeleton Spindle Assembly Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion INTAC Complex FAR/SIN/STRIPAK Complex Microtubule Cytoskeleton Organization RNA Polymerase II Transcription Initiation Surveillance Chromosome, Centromeric Region Spindle Organization Negative Regulation Of Hippo Signaling RNA Catabolic Process T Cell Homeostasis Chromosome Sister Chromatid Cohesion Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Membraneless Organelle Assembly DNA-templated Transcription Elongation Microtubule-based Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Lymphocyte Homeostasis Nucleobase-containing Compound Catabolic Process Regulation Of Microtubule Polymerization RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Meiotic Spindle Elongation Chromosome Organization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Leukocyte Homeostasis Cytoskeleton Organization Protein Serine/threonine Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Regulation Of Microtubule Polymerization Or Depolymerization U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Mitotic Cell Cycle Cytosol Chromosome Segregation Positive Regulation Of Apoptotic Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Mitotic Sister Chromatid Separation
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