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SET and GZMK
Number of citations of the paper that reports this interaction (PMID
17008916
)
13
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study)
SET
GZMK
Gene Name
SET nuclear proto-oncogene
granzyme K (granzyme 3; tryptase II)
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Protein Complex
Perinuclear Region Of Cytoplasm
Extracellular Region
Molecular Function
DNA Binding
Protein Phosphatase Inhibitor Activity
Protein Binding
Protein Phosphatase Type 2A Regulator Activity
Histone Binding
Serine-type Endopeptidase Activity
Serine-type Peptidase Activity
Biological Process
Mitotic Cell Cycle
DNA Replication
Nucleosome Assembly
Nucleosome Disassembly
Nucleocytoplasmic Transport
Gene Expression
Negative Regulation Of Histone Acetylation
Negative Regulation Of Catalytic Activity
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Catalytic Activity
Proteolysis
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
Mitotic Prophase
Condensation of Prophase Chromosomes
HuR stabilizes mRNA
Cell Cycle, Mitotic
M Phase
Drugs
Diseases
GWAS
Eating disorders (purging via substances) (
23568457
)
Protein-Protein Interactions
51 interactors:
ANP32A
APEX1
APP
CALM1
CDK5
CDK5R1
CDKN1A
CHAF1A
CHRM2
CHRM3
ELAVL1
ELF4
EP300
FAM111B
FOS
GZMA
GZMK
HDAC1
HIST1H2BA
HIST1H3A
HIST2H4A
HIST3H3
HIST4H4
HMGB2
IRF1
JUNB
KLF5
KMT2A
MDM2
MEOX2
MTERF1
NME1
NUCB1
NUPR1
PIK3CG
PPP2CA
PPP2R1B
PRKAR1A
PTMA
RAC1
SDCBP
SETBP1
SGOL1
TAF1A
TERF1
TERF2
TERF2IP
THAP7
TP53
TREX1
UCHL5
12 interactors:
ACTG1
APEX1
GOLGA2
HMGB2
HNRNPK
LIG4
NPLOC4
PNKP
SET
TUBB3
UFD1L
VCP
Entrez ID
6418
3003
HPRD ID
09023
02872
Ensembl ID
ENSG00000119335
Uniprot IDs
Q01105
Q5VXV3
P49863
PDB IDs
2E50
1MZA
1MZD
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Metabolic Process
Regulation Of Cell Cycle
Cellular Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
Chromosome Organization
Regulation Of Transcription, DNA-templated
Cell Death
Death
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Gene Expression
Telomere Maintenance
Developmental Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Apoptotic Process
Programmed Cell Death
Regulation Of Cell Cycle Process
Cellular Metabolic Process
DNA Replication-dependent Nucleosome Assembly
Cell Cycle
Transcription, DNA-templated
Organelle Organization
Regulation Of Gene Expression, Epigenetic
Blood Coagulation
Positive Regulation Of Protein Metabolic Process
Chromatin Assembly
RNA Biosynthetic Process
Cellular Component Assembly
Hemostasis
Chromatin Organization
Negative Regulation Of Cell Cycle
Anatomical Structure Development
Cellular Response To Growth Factor Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Body Fluid Levels
Negative Regulation Of Transcription, DNA-templated
Response To Growth Factor
Negative Regulation Of Gene Expression
Cellular Macromolecule Catabolic Process
DNA Metabolic Process
DNA Repair
DNA Replication
DNA Ligation Involved In DNA Repair
Nucleotide-excision Repair
DNA-dependent DNA Replication
DNA Ligation
Nucleotide-excision Repair, DNA Gap Filling
Cellular Response To DNA Damage Stimulus
DNA Catabolic Process
Double-strand Break Repair
V(D)J Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Catabolic Process
ER-associated Ubiquitin-dependent Protein Catabolic Process
DNA Recombination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Organelle Organization
Cell Cycle
Mitotic Cell Cycle
Nucleic Acid Phosphodiester Bond Hydrolysis
Base-excision Repair
DNA Ligation Involved In DNA Recombination
Positive Regulation Of Lys63-specific Deubiquitinase Activity
Positive Regulation Of Protein K63-linked Deubiquitination
Cellular Response To Stress
DNA Catabolic Process, Endonucleolytic
Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Polynucleotide 3' Dephosphorylation
Chromosome Organization
Protein Complex Assembly
Aromatic Compound Catabolic Process
DNA Biosynthetic Process
Cellular Component Assembly
Nucleosome Assembly
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process
Chromatin Assembly
Proteolysis Involved In Cellular Protein Catabolic Process
Nucleosome Organization
Cellular Protein Catabolic Process
Base-excision Repair, DNA Ligation
Retrograde Protein Transport, ER To Cytosol
Chromatin Assembly Or Disassembly
Regulation Of Protein Deubiquitination
Lagging Strand Elongation
Tagcloud
?
already
assessing
cognition
cognitive
cogs
computation
correlating
costs
cps
deterioration
easy
estimate
exam
global
inasmuch
mds
meaningful
mental
mini
minimum
msd
quite
residents
scale
scales
simple
slightly
straightforward
substantially
utility
Tagcloud (Difference)
?
already
assessing
cognition
cognitive
cogs
computation
correlating
costs
cps
deterioration
easy
estimate
exam
global
inasmuch
mds
meaningful
mental
mini
minimum
msd
quite
residents
scale
scales
simple
slightly
straightforward
substantially
utility
Tagcloud (Intersection)
?