SET and IRF1

Number of citations of the paper that reports this interaction (PubMedID 23134341)
0

Data Source:
BioGRID (pull down)

		SET	IRF1
Description		SET nuclear proto-oncogene	interferon regulatory factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Histone Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	DNA Replication Nucleosome Assembly Nucleosome Disassembly Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription	Immune System Process Regulation Of Adaptive Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Interferon-beta CD8-positive, Alpha-beta T Cell Differentiation Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Regulation Of Cell Cycle Type II Interferon-mediated Signaling Pathway Cellular Response To Mechanical Stimulus Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA	Pyroptosis Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)	Aspartate aminotransferase levels ( 33547301) Asthma ( 29273806 30929738 31619474 31959851) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433) Asthma (sex interaction) ( 24824216) Asthma or allergic disease (pleiotropy) ( 29785011) C-reactive protein levels ( 21300955) Carotid plaque maximum area ( 32469969) Crohn's disease ( 28067908 21102463) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 27841878) Fibrinogen ( 20031577 20031576 23969696) Inflammatory bowel disease ( 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Maximum stenosis ( 32469969) Mean area of carotid plaque ( 32469969) Mean degree of stenosis ( 32469969) Platelet count ( 22139419 32888494) Plateletcrit ( 27863252 32888494) Polycystic ovary syndrome ( 30566500) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum of carotid plaque area ( 32469969) Systemic lupus erythematosus ( 33272962) Type 1 diabetes ( 34012112) Ulcerative colitis ( 28067908)
Interacting Genes		69 interacting genes: ANP32A APEX1 APP CALM1 CDCA8 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 ENO1 EP300 ESR1 FAM111B FBXO7 FOS FOXO1 GZMA GZMK H1-1 H2BC1 H3-3A H3-4 H4C14 H4C16 HMGB2 IRF1 JUNB KLF5 KMT2A LGMN MDM2 MEOX2 MTERF1 NEDD8 NME1 NUCB1 NUPR1 PAX6 PIK3CG PPP2CA PPP2R1B PRKAR1A PTEN PTMA RAC1 SDCBP SETBP1 SGO1 SGO2 TAF1A TERF1 TERF2 TERF2IP TEX35 THAP7 TLE5 TREX1 TRIM55 TRIM63 UBE3A UCHL5 XRCC6 ZNF17 ZNF438 ZNF85	23 interacting genes: CDKN1B CREBBP DCAF1 EP300 GSK3B HMGA1 IRF8 IRF9 KAT2A KAT2B KEAP1 MDM2 NFKB1 NPM1 QARS1 RELA SET SPI1 SPOP STAT1 TRAF3 TRIM28 YBX1
Entrez ID		6418	3659
HPRD ID		09023	00961
Ensembl ID		ENSG00000119335	ENSG00000125347
Uniprot IDs		A0A8J8YYJ1 Q01105 Q5VXV3	A0A7P0TAL6 P10914 Q6FHN8 X5D3F6
PDB IDs		2E50 7MTO
Enriched GO Terms of Interacting Partners?		Nucleus DNA Binding Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Telomere Organization Chromosome, Telomeric Region Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Organization Regulation Of Multicellular Organismal Process Chromatin Remodeling Regulation Of Gene Expression Regulation Of Phosphorus Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Double-stranded Telomeric DNA Binding Nuclear Telomere Cap Complex Regulation Of Purine Nucleotide Metabolic Process Nucleosome Organization Regulation Of Developmental Process Protein-DNA Complex Assembly Regulation Of Glycolytic Process Regulation Of Cell Cycle Regulation Of Carbohydrate Catabolic Process Protein-containing Complex Negative Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of Programmed Cell Death Protein-DNA Complex Double-stranded DNA Binding Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process	Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation DNA-binding Transcription Factor Binding Chromatin Organization Chromatin Remodeling Transcription Coactivator Binding Acetyltransferase Activity Transcription Coregulator Activity Positive Regulation Of Gene Expression Regulation Of Cellular Response To Stress Response To Stress Histone Acetyltransferase Complex Protein-containing Complex Protein-lysine-acetyltransferase Activity Cellular Response To Cytokine Stimulus Transcription Coactivator Activity Histone Acetyltransferase Activity NF-kappaB Binding
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