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SET and PPP2CA
Number of citations of the paper that reports this interaction (PubMedID
25128526
)
73
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
SET
PPP2CA
Description
SET nuclear proto-oncogene
protein phosphatase 2 catalytic subunit alpha
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Lipid Droplet
Cytosol
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Chromatin
Spindle Pole
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Cytosol
Cytoskeleton
Plasma Membrane
Protein Serine/threonine Phosphatase Complex
Microtubule Cytoskeleton
Membrane
Membrane Raft
Synapse
Extracellular Exosome
FAR/SIN/STRIPAK Complex
INTAC Complex
Molecular Function
DNA Binding
Chromatin Binding
Protein Phosphatase Inhibitor Activity
Protein Binding
Protein Phosphatase Regulator Activity
Histone Binding
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
Metal Ion Binding
Protein Heterodimerization Activity
Tau Protein Binding
GABA Receptor Binding
RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity
RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity
Biological Process
DNA Replication
Nucleosome Assembly
Nucleosome Disassembly
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Mitotic Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Protein Dephosphorylation
Mesoderm Development
Response To Lead Ion
Negative Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Microtubule Polymerization
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Peptidyl-threonine Dephosphorylation
Regulation Of Growth
T Cell Homeostasis
Regulation Of Cell Differentiation
Meiotic Cell Cycle
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Canonical Wnt Signaling Pathway
Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress
RNA Polymerase II Transcription Initiation Surveillance
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Condensation of Prophase Chromosomes
HuR (ELAVL1) binds and stabilizes mRNA
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Initiation of Nuclear Envelope (NE) Reformation
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Vitamin E
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Axial length (
24144296
)
Body mass index (
26426971
)
Eating disorders (purging via substances) (
23568457
)
Interacting Genes
69 interacting genes:
ANP32A
APEX1
APP
CALM1
CDCA8
CDK5
CDK5R1
CDKN1A
CHAF1A
CHRM2
CHRM3
ELAVL1
ELF4
ENO1
EP300
ESR1
FAM111B
FBXO7
FOS
FOXO1
GZMA
GZMK
H1-1
H2BC1
H3-3A
H3-4
H4C14
H4C16
HMGB2
IRF1
JUNB
KLF5
KMT2A
LGMN
MDM2
MEOX2
MTERF1
NEDD8
NME1
NUCB1
NUPR1
PAX6
PIK3CG
PPP2CA
PPP2R1B
PRKAR1A
PTEN
PTMA
RAC1
SDCBP
SETBP1
SGO1
SGO2
TAF1A
TERF1
TERF2
TERF2IP
TEX35
THAP7
TLE5
TREX1
TRIM55
TRIM63
UBE3A
UCHL5
XRCC6
ZNF17
ZNF438
ZNF85
101 interacting genes:
ADCY8
AKAP6
AKT1
AKT3
AMOTL2
APC
AXIN1
BCL2
BEST1
BMPR1B
BRAF
C3orf36
CAD
CAMK1
CARD11
CAV1
CCNG1
CCNG2
CDC42BPB
CDK2
CDK6
CDKN2C
CEBPA
CHEK2
CLPP
CSNK2B
CXCR2
DELEC1
DVL3
EEF2
EIF4EBP1
ETF1
FCAR
GABRB3
GAD1
GOLGA2
HTT
IGBP1
ISYNA1
JAK2
KISS1R
L3MBTL3
MAP4K1
MAP4K3
MAP4K4
MAPK1
MAPK3
MAPT
MID1
MRPS26
MYC
MYH9
NME2
NOSIP
NXN
PACS1
PAK1
PIM1
POLR2A
PPP1CA
PPP2R1A
PPP2R1B
PPP2R2A
PPP2R3B
PPP2R5B
PPP2R5C
PPP2R5E
PRKAA1
PRKCD
PTEN
PTN
PXN
PYGM
RACGAP1
RBL2
RELA
RHO
RHOB
RORC
RPS6KB1
RRAS
SET
SGK1
SGO1
SGO2
STAT5A
STAT5B
STRN
TIAM1
TLX1
TP53
TRIM28
TRIM35
TRIP13
TSC2
UBAP2
UBC
VAC14
VDR
XRN1
YPEL3
Entrez ID
6418
5515
HPRD ID
09023
08912
Ensembl ID
ENSG00000119335
ENSG00000113575
Uniprot IDs
A0A8J8YYJ1
Q01105
Q5VXV3
B3KQ51
B3KUN1
P67775
PDB IDs
2E50
7MTO
2IAE
2IE3
2IE4
2NPP
2NYL
2NYM
3C5W
3DW8
3FGA
3K7V
3K7W
3P71
4I5L
4I5N
4IYP
4LAC
4NY3
5W0W
6NTS
7CUN
7K36
7PKS
7SOY
7YCX
8RBX
8RBZ
8RC4
8SO0
8TTB
8TWE
8TWI
8U1X
8U89
8UWB
8YJB
Enriched GO Terms of Interacting Partners
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Nucleus
DNA Binding
Chromosome Organization
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Negative Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromosome
Telomere Organization
Chromosome, Telomeric Region
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Chromatin Organization
Regulation Of Multicellular Organismal Process
Chromatin Remodeling
Regulation Of Gene Expression
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Nucleosome Assembly
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of ATP Metabolic Process
Double-stranded Telomeric DNA Binding
Nuclear Telomere Cap Complex
Regulation Of Purine Nucleotide Metabolic Process
Nucleosome Organization
Regulation Of Developmental Process
Protein-DNA Complex Assembly
Regulation Of Glycolytic Process
Regulation Of Cell Cycle
Regulation Of Carbohydrate Catabolic Process
Protein-containing Complex
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Chromatin
Regulation Of Programmed Cell Death
Protein-DNA Complex
Double-stranded DNA Binding
Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Signal Transduction
Intracellular Signal Transduction
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine Kinase Activity
Cytosol
Regulation Of Cell Population Proliferation
Protein Phosphatase Regulator Activity
Protein Phosphorylation
Protein Phosphatase Type 2A Complex
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Kinase Activity
Phosphorylation
Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Apoptotic Process
Regulation Of Cell Cycle
Programmed Cell Death
Cell Death
Protein Phosphatase 2A Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Phosphate-containing Compound Metabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
Cytoplasm
Nucleus
Response To Ketone
Response To Lipid
Regulation Of Mitotic Cell Cycle
Response To Starvation
Positive Regulation Of Intracellular Signal Transduction
Protein Modification Process
Regulation Of Cell Differentiation
Positive Regulation Of Cell Population Proliferation
Identical Protein Binding
Positive Regulation Of Apoptotic Process
Cellular Response To Stress
Protein Metabolic Process
Response To Nutrient Levels
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cellular Component Organization
Cellular Response To Oxygen-containing Compound
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Tagcloud (Difference)
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Tagcloud (Intersection)
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