TAF1A and RUNX2

Number of citations of the paper that reports this interaction (PubMedID 17251981)
0

Data Source:
HPRD (in vivo)

		TAF1A	RUNX2
Description		TATA-box binding protein associated factor, RNA polymerase I subunit A	RUNX family transcription factor 2
Image		No pdb structure
GO Annotations	Cellular Component	RNA Polymerase I Transcription Regulator Complex Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus Microtubule Cytoskeleton	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding ATP Binding Protein Domain Specific Binding Chromatin DNA Binding BHLH Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription By RNA Polymerase I Transcription By RNA Polymerase II	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Osteoblast Fate Commitment Chondrocyte Differentiation Chondrocyte Development Osteoblast Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Smoothened Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Hemopoiesis Cell Differentiation Neuron Differentiation T Cell Differentiation Regulation Of Ossification Bone Mineralization BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Ligamentous Ossification Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation SMAD Protein Signal Transduction Stem Cell Proliferation Response To Sodium Phosphate Positive Regulation Of Stem Cell Proliferation
Pathways		SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases			Cleidocranial dysplasia
GWAS		Trunk fat mass ( 28552196)	Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 29760442) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) facial morphology traits (multivariate analysis) ( 27193062) Gout (normal type) ( 32238385) Height ( 18391951 25429064) Hip minimal joint space width ( 27701424) Hip shape (DXA scan) ( 30320955) Intraocular pressure ( 29785010 30054594) Itch intensity from mosquito bite ( 28199695) LDL cholesterol levels in HIV infection ( 33109212) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Periodontal microbiota ( 22699663) Progressive supranuclear palsy ( 30089514) Relative brain age ( 34098431) Subcortical volume (MOSTest) ( 32665545) Survival in pancreatic cancer ( 28470677) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		20 interacting genes: ANP32A ESR1 H2AC20 H2BC21 H3-4 H3C1 H4C1 H4C16 JMJD6 NKAPD1 POLR1G RRN3 RUNX2 SET TAF12 TAF1B TAF1C TBP TP53 UBTF	41 interacting genes: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DTX2 DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HDAC7 HES1 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PIN1 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF USP24 XRCC5 XRCC6 YAP1
Entrez ID		9015	860
HPRD ID		05362	02566
Ensembl ID		ENSG00000143498	ENSG00000124813
Uniprot IDs		A8K4K5 B4DS21 Q15573	A0A0D9SEN7 Q13950 Q32MY8
PDB IDs			6VG8 6VGD 6VGE 6VGG
Enriched GO Terms of Interacting Partners?		Protein-DNA Complex Assembly Protein-containing Complex Assembly RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Protein-containing Complex Organization Transcription Initiation At RNA Polymerase I Promoter DNA Binding DNA-templated Transcription Initiation Nucleoplasm Structural Constituent Of Chromatin Chromatin Remodeling Cellular Component Assembly Nucleosome Assembly Protein Heterodimerization Activity Transcription By RNA Polymerase I Nucleosome Nucleosome Organization Chromatin Organization DNA-templated Transcription RNA Polymerase Transcription Factor SL1 Complex RNA Polymerase I General Transcription Initiation Factor Activity Nucleus Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Regulation Of DNA-templated Transcription Initiation RRNA Transcription TBP-class Protein Binding Nucleic Acid Metabolic Process RNA Polymerase I Transcription Regulator Complex TFIIB-class Transcription Factor Binding Chromosome Fibroblast Proliferation Protein-containing Complex RNA Polymerase II Preinitiation Complex Assembly Protein Localization To Chromatin Nucleobase-containing Compound Metabolic Process MRNA Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Nucleolus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Chromatin Binding Core Promoter Sequence-specific DNA Binding CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome Stem Cell Differentiation	Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Binding Regulation Of Cell Differentiation Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Cell Differentiation Cellular Developmental Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process R-SMAD Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Cell Population Proliferation Regulation Of MiRNA Transcription Chromatin DNA-templated Transcription Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of MiRNA Metabolic Process
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