TAF1A and RUNX2

Number of citations of the paper that reports this interaction (PMID 17251981)
77

Data Source:
HPRD (in vivo)

		TAF1A	RUNX2
Gene Name		TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	runt-related transcription factor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	RNA Polymerase I Transcription Factor Complex Nucleus Nucleoplasm Microtubule Cytoskeleton Intracellular Membrane-bounded Organelle	Nuclear Chromatin Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding ATP Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Repressing Transcription Factor Binding
	Biological Process	Chromatin Silencing At RDNA Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Ossification Osteoblast Differentiation Endochondral Ossification Osteoblast Fate Commitment Chondrocyte Development Osteoblast Development Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Gene Expression T Cell Differentiation BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Maturation Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression SIRT1 negatively regulates rRNA Expression Negative epigenetic regulation of rRNA expression	Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS			Height ( 18391951) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		21 interactors: ANP32A C11orf57 CD3EAP ESR1 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HIST4H4 JMJD6 RRN3 RUNX2 SET TAF12 TAF1B TAF1C TAF1D TBP TP53 UBTF	36 interactors: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF XRCC5 XRCC6 YAP1
Entrez ID		9015	860
HPRD ID		05362	02566
Ensembl ID		ENSG00000143498	ENSG00000124813
Uniprot IDs		A8K4K5 B4DS21 Q15573	F8W8U5 Q13950 Q32MY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Negative Regulation Of Gene Expression, Epigenetic Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Chromatin Silencing DNA-templated Transcription, Initiation Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Gene Silencing Negative Regulation Of Gene Expression Gene Expression Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Termination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Chromosome Organization Nitrogen Compound Metabolic Process Chromatin Assembly Regulation Of Gene Expression Chromatin Assembly Or Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein-DNA Complex Assembly RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Packaging Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleosome Assembly Cellular Macromolecule Biosynthetic Process DNA Replication-dependent Nucleosome Assembly Macromolecule Biosynthetic Process DNA Conformation Change Nucleosome Organization RNA Metabolic Process DNA Methylation On Cytosine RRNA Transcription Regulation Of Metabolic Process Organelle Organization Biosynthetic Process Negative Regulation Of Cellular Metabolic Process	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Organ Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Cellular Metabolic Process Cellular Response To Stimulus Tissue Development Cellular Response To Stress System Development Regulation Of Cell Differentiation Response To Growth Factor Developmental Process Heart Development Positive Regulation Of Cell Differentiation Cardiovascular System Development Cell Differentiation Negative Regulation Of Signal Transduction
Tagcloud ?		analysed blocking c8 coding crc frameshift gc harboured heterogeneity instability intratumoural ith microsatellite mononucleotide msi mss mutational regional ribosomal rrna somatic strand summary taf1b taf1c tata tbp tumourigenesis ubf	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx3 syndromes unmethylated
Tagcloud (Difference) ?		analysed blocking c8 coding crc frameshift gc harboured heterogeneity instability intratumoural ith microsatellite mononucleotide msi mss mutational regional ribosomal rrna somatic strand summary taf1b taf1c tata tbp tumourigenesis ubf	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx3 syndromes unmethylated
Tagcloud (Intersection) ?