TAF1A

Gene Name		TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	RNA Polymerase I Transcription Factor Complex Nucleus Nucleoplasm Microtubule Cytoskeleton Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Protein Binding
	Biological Process	Chromatin Silencing At RDNA Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression SIRT1 negatively regulates rRNA Expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-protein Interactions		21 interactors: ANP32A C11orf57 CD3EAP ESR1 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HIST4H4 JMJD6 RRN3 RUNX2 SET TAF12 TAF1B TAF1C TAF1D TBP TP53 UBTF
Entrez ID		9015
HPRD ID		05362
Ensembl ID		ENSG00000143498
Uniprot IDs		A8K4K5 B4DS21 Q15573
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Silencing At RDNA Negative Regulation Of Gene Expression, Epigenetic Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Chromatin Silencing DNA-templated Transcription, Initiation Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Gene Silencing Negative Regulation Of Gene Expression Gene Expression Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Termination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Chromosome Organization Nitrogen Compound Metabolic Process Chromatin Assembly Regulation Of Gene Expression Chromatin Assembly Or Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein-DNA Complex Assembly RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Packaging Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleosome Assembly Cellular Macromolecule Biosynthetic Process DNA Replication-dependent Nucleosome Assembly Macromolecule Biosynthetic Process DNA Conformation Change Nucleosome Organization RNA Metabolic Process DNA Methylation On Cytosine RRNA Transcription Regulation Of Metabolic Process Organelle Organization Biosynthetic Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		analysed blocking c8 coding crc frameshift gc harboured heterogeneity instability intratumoural ith microsatellite mononucleotide msi mss mutational regional ribosomal rrna somatic strand summary taf1b taf1c tata tbp tumourigenesis ubf