ANP32A and E4F1

Number of citations of the paper that reports this interaction (PubMedID 17557114)
29

Data Source:
HPRD (two hybrid, in vivo)

		ANP32A	E4F1
Description		acidic nuclear phosphoprotein 32 family member A	E4F transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Spindle Nuclear Body
	Molecular Function	RNA Binding Protein Binding Histone Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Transferase Activity CAMP Response Element Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nucleocytoplasmic Transport Intracellular Signal Transduction Regulation Of Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Cell Cycle Process Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II Cell Division Regulation Of Cell Cycle
Pathways		HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS		Esophageal cancer ( 21642993)	Appendicular lean mass ( 33097823)
Interacting Genes		30 interacting genes: ADAP1 APEX1 ATXN1 AXIN1 CHAF1A E4F1 ELAVL1 H2AC20 H2BC21 H3-4 H3C1 H3C15 H4C1 H4C16 HSPB3 KPNA1 KPNA5 KPNA6 LHX3 LINC00632 MAP1B NSFL1C PCBP1 PGR PPARG PTPRC SET TAF1A THRB XPO1	16 interacting genes: ANP32A ATM ATR CDKN2A EHMT2 HMGA2 KRTAP10-4 KRTAP10-7 PARP1 PRKDC RASSF1 RB1 SMAD9 SMARCA4 TP53 UPF2
Entrez ID		8125	1877
HPRD ID		09014	04317
Ensembl ID		ENSG00000140350	ENSG00000167967
Uniprot IDs		A0A384P5U2 P39687	H3BSL4 H3BUJ7 Q66K89
PDB IDs		2JE0 2JE1 4XOS 6XZQ 8RMR 8RN0 8RNA 8RNB 8RNC
Enriched GO Terms of Interacting Partners?		Nucleosome Assembly Nucleosome Organization Structural Constituent Of Chromatin Nucleus Protein-DNA Complex Assembly Nucleosome Chromatin Remodeling DNA Binding Chromatin Organization Nuclear Transport Nucleocytoplasmic Transport NLS-dependent Protein Nuclear Import Complex Nucleoplasm Protein Heterodimerization Activity Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Negative Regulation Of Macromolecule Biosynthetic Process NLS-bearing Protein Import Into Nucleus Protein Localization To Organelle Negative Regulation Of Biosynthetic Process Protein Localization To Nucleus Negative Regulation Of RNA Metabolic Process Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Protein-containing Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Protein Import Into Nucleus DNA Replication-dependent Chromatin Assembly Import Into Nucleus Telomere Organization Transcription Coactivator Binding Nuclear Receptor Activity Protein-containing Complex Organization Cellular Component Assembly Negative Regulation Of Metabolic Process Transcription By RNA Polymerase II Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Localization In Cell Positive Regulation Of Transcription By RNA Polymerase II Chromosome, Telomeric Region Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin	Chromosome Organization Replicative Senescence Histone H2AXS139 Kinase Activity Response To Gamma Radiation Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Process Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Chromatin Organization RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Signal Transduction By P53 Class Mediator Protein Localization To Chromosome Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of DNA Repair Regulation Of Chromosome Organization Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Ionizing Radiation Regulation Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Senescence Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle P53 Binding Intracellular Signal Transduction Protein Localization To Organelle Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Ras Protein Signal Transduction Negative Regulation Of Mitotic Cell Cycle Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Double-strand Break Repair Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Localization To Site Of Double-strand Break DNA Damage Checkpoint Signaling Disordered Domain Specific Binding Telomere Maintenance
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