NCAPH and H2AC20

Number of citations of the paper that reports this interaction (PubMedID 21633354)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		NCAPH	H2AC20
Description		non-SMC condensin I complex subunit H	H2A clustered histone 20
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Membrane	Nucleosome Nucleus Chromosome Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Binding	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Mitotic Chromosome Condensation Female Meiotic Nuclear Division Meiotic Chromosome Condensation Chromosome Condensation Meiotic Chromosome Segregation Cell Division Female Meiosis Chromosome Separation Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation	Heterochromatin Formation
Pathways		Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27618452) Monocyte count ( 32888494)
Interacting Genes		6 interacting genes: AURKB CAPG CDK1 H2AC20 H2AZ1 TBP	72 interacting genes: ANP32A APP ATXN7L3 BAP1 BARD1 BMI1 BRCA1 CDY1 CEBPA CRP CSTF1 CTCFL DDB2 DNMT3L EIF2AK2 EP300 ESR1 FBL GATAD2A GATAD2B H2BC1 H4C14 HAT1 HDAC2 KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAA40 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 POT1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 STK38 TAF15 TAF1A TAF1B TCF20 TRIM37 TSPY1 TSSK6 UBC UBE2B UBE2H UBR2 UIMC1 USP10 USP12 USP16 USP2 USP22 USP46 USP51 USP7 USP8
Entrez ID		23397	8338
HPRD ID		03820	09107
Ensembl ID		ENSG00000121152	ENSG00000184260
Uniprot IDs		B4DRG7 Q15003	Q16777
PDB IDs		6IGX	6Y5E 7U0G 7U0I 7U0J 8DK5 8EVG 8EVH 8EVI 8EVJ 8SPS 8SPU 8SYP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Metaphase Plate Congression Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Kinetochore RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Attachment Of Spindle Microtubules To Kinetochore Chromosome Positive Regulation Of Chromosome Segregation Protein Localization To Chromosome, Centromeric Region Spindle Microtubule Cell Cycle G2/M Phase Transition Euchromatin Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Pronuclear Fusion Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Structural Constituent Of Chromatin Regulation Of Protein Depolymerization Positive Regulation Of Organelle Organization Protein Localization To Chromosome Mitotic DNA-templated DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cyclin B1-CDK1 Complex Positive Regulation Of Chromosome Organization Cyclin A1-CDK1 Complex Regulation Of Cell Cycle G2/M Phase Transition Cyclin A2-CDK1 Complex Nucleosome Mitotic Sister Chromatid Biorientation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Regulation Of Protein-containing Complex Disassembly Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Spindle Chromatin Remodeling Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Regulation Of Chromosome Segregation Cyclin-dependent Protein Kinase Activity Heterochromatin Formation Regulation Of Schwann Cell Differentiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Cell Cycle Phase Transition TFIIB-class Transcription Factor Binding Mitotic Cytokinesis Checkpoint Signaling Sister Chromatid Biorientation Negative Regulation Of Gene Expression, Epigenetic Midbody Thymidine Biosynthetic Process	Chromatin Organization Chromatin Remodeling Nucleus Histone Binding Nucleoplasm Epigenetic Regulation Of Gene Expression Chromatin Binding Chromosome Protein Modification Process Macromolecule Metabolic Process Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Regulation Of Gene Expression Histone H4 Acetyltransferase Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone H2A Deubiquitinase Activity Protein Deubiquitination Regulation Of DNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity DNA Damage Response Protein Modification By Small Protein Removal Negative Regulation Of Biosynthetic Process Transferase Activity Nucleic Acid Metabolic Process DNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Cysteine-type Peptidase Activity Protein-containing Complex Positive Regulation Of DNA-templated Transcription
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