CRP and H2AC16

Number of citations of the paper that reports this interaction (PubMedID 1989977)
0

Data Source:
HPRD (in vitro, in vivo)

		CRP	H2AC16
Description		C-reactive protein	H2A clustered histone 16
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleosome Nucleus Chromosome Extracellular Exosome
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding	DNA Binding Protein Binding Enzyme Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Acute-phase Response Inflammatory Response Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Innate Immune Response Defense Response To Gram-positive Bacterium	Heterochromatin Formation
Pathways		Classical antibody-mediated complement activation	HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events
Drugs		N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases		Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576 23696881) C-reactive protein ( 18439548 18439552 23844046 19567438 21196492 21647738 22492993 22939635) C-reactive protein levels ( 28548082 24763700 29403010 29878111 30388399 33227023 33339817 21300955) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Erythropoietin levels ( 33227023) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877)
Interacting Genes		22 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A	5 interacting genes: BRD7 CRP GADD45A SAP30 TERF2IP
Entrez ID		1401	8332
HPRD ID		00422	09103
Ensembl ID		ENSG00000132693	ENSG00000276903
Uniprot IDs		P02741 Q5VVP7	A4FTV9 P0C0S8
PDB IDs		1B09 1GNH 1LJ7 3L2Y 3PVN 3PVO 7PK9 7PKB 7PKD 7PKE 7PKF 7PKG 7PKH 7TBA 8WV4 8WV5	4QYL 5KGF 6R0C 6RNY 6X59 6X5A 6XJD 7BG9 7E8D 7JO9 7JOA 7TAN 7U50 7U51 7U52 7U53 7UV9 8ATF 8AV6 8GUI 8GUJ 8GUK 8OFF 8QZM 8VOB 8VWS 8VWT 8VWU 8VWV 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM
Enriched GO Terms of Interacting Partners?		IgG Binding Acute Inflammatory Response IgG Receptor Activity Regulation Of Immune System Process Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Regulation Of Immune Response Interleukin-34-mediated Signaling Pathway Lung Morphogenesis Fc-gamma Receptor Signaling Pathway Endocytosis Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Inflammatory Response To Antigenic Stimulus Regulation Of Stress-activated MAPK Cascade Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of Stress-activated Protein Kinase Signaling Cascade Immunoglobulin Mediated Immune Response Positive Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Regulation Of Acute Inflammatory Response B Cell Mediated Immunity Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Positive Regulation Of Endocytosis Fc Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Defense Response Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Leukocyte Proliferation Regulation Of Tumor Necrosis Factor Production Bergmann Glial Cell Differentiation Glial Cell Development Import Into Cell Negative Regulation Of Acute Inflammatory Response Regulation Of Lymphocyte Mediated Immunity Immune Effector Process Positive Regulation Of Phagocytosis Leukocyte Mediated Cytotoxicity Regulation Of Cell Activation Response To External Biotic Stimulus Regulation Of MAPK Cascade Regulation Of Natural Killer Cell Proliferation Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response	Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Double-strand Break Repair Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Developmental Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Choline Binding Regulation Of Developmental Process Negative Regulation Of Peptidyl-serine Phosphorylation Transcription Corepressor Activity Histone H3K14ac Reader Activity Regulation Of Chromosome Organization Regulation Of DNA Repair Protection From Non-homologous End Joining At Telomere Shelterin Complex Negative Regulation Of Macromolecule Metabolic Process Complement Component C1q Complex Binding Positive Regulation Of DNA Metabolic Process Nuclear Telomere Cap Complex Virion Binding Negative Regulation Of Metabolic Process G-rich Strand Telomeric DNA Binding Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of RNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Telomere Capping Telomere Maintenance In Response To DNA Damage Low-density Lipoprotein Particle Binding Opsonization Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Locomotion Regulation Of RNA Biosynthetic Process RSC-type Complex Positive Regulation Of Superoxide Anion Generation Regulation Of Phosphorylation Negative Regulation Of Lipid Storage
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