CRP and GLUD1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CRP	GLUD1
Description		C-reactive protein	glutamate dehydrogenase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding	Nucleotide Binding Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Glutamate Dehydrogenase (NADP+) Activity Protein Binding ATP Binding GTP Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity ADP Binding NAD+ Binding L-leucine Binding
	Biological Process	Acute-phase Response Inflammatory Response Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Innate Immune Response Defense Response To Gram-positive Bacterium	Amino Acid Metabolic Process Glutamate Biosynthetic Process L-glutamate Catabolic Process Glutamine Metabolic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Tricarboxylic Acid Metabolic Process
Pathways		Classical antibody-mediated complement activation	Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism Mitochondrial protein degradation
Drugs		N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139	Glutamic acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride
Diseases		Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576 23696881) C-reactive protein ( 18439548 18439552 23844046 19567438 21196492 21647738 22492993 22939635) C-reactive protein levels ( 28548082 24763700 29403010 29878111 30388399 33227023 33339817 21300955) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Erythropoietin levels ( 33227023) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877)	Renal underexcretion gout ( 32238385)
Interacting Genes		22 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A	16 interacting genes: ASGR2 CRP CUL3 DYNLL1 GOT2 HPX HSD17B10 KLHL22 LSM1 NR4A1 OGT ORM1 RNF213 STAT5A TIAM1 VTN
Entrez ID		1401	2746
HPRD ID		00422	11748
Ensembl ID		ENSG00000132693	ENSG00000148672
Uniprot IDs		P02741 Q5VVP7	E9KL48 P00367
PDB IDs		1B09 1GNH 1LJ7 3L2Y 3PVN 3PVO 7PK9 7PKB 7PKD 7PKE 7PKF 7PKG 7PKH 7TBA 8WV4 8WV5	1L1F 1NR1 6DQG 7UZM 8KGY 8SK8 8W4J
Enriched GO Terms of Interacting Partners?		IgG Binding Acute Inflammatory Response IgG Receptor Activity Regulation Of Immune System Process Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Regulation Of Immune Response Interleukin-34-mediated Signaling Pathway Lung Morphogenesis Fc-gamma Receptor Signaling Pathway Endocytosis Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Inflammatory Response To Antigenic Stimulus Regulation Of Stress-activated MAPK Cascade Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of Stress-activated Protein Kinase Signaling Cascade Immunoglobulin Mediated Immune Response Positive Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Regulation Of Acute Inflammatory Response B Cell Mediated Immunity Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Positive Regulation Of Endocytosis Fc Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Defense Response Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Leukocyte Proliferation Regulation Of Tumor Necrosis Factor Production Bergmann Glial Cell Differentiation Glial Cell Development Import Into Cell Negative Regulation Of Acute Inflammatory Response Regulation Of Lymphocyte Mediated Immunity Immune Effector Process Positive Regulation Of Phagocytosis Leukocyte Mediated Cytotoxicity Regulation Of Cell Activation Response To External Biotic Stimulus Regulation Of MAPK Cascade Regulation Of Natural Killer Cell Proliferation Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response	Positive Regulation Of Gene Expression Non-canonical Inflammasome Complex Assembly Polar Microtubule Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of TORC1 Signaling Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Inflammatory Response Cell-matrix Adhesion Cellular Component Assembly Transcription By RNA Polymerase II Defense Response Response To Peptide Hormone Blood Microparticle Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lymphocyte Mediated Immunity Mitotic Spindle Positive Regulation Of Biosynthetic Process Asialoglycoprotein Receptor Activity Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Cytokine Production Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Acute-phase Response Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Mononuclear Cell Proliferation Acute Inflammatory Response DNA-templated Transcription Mesenchymal Stem Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Cellular Response To Oxygen-containing Compound Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Gastrulation Positive Regulation Of Cell Population Proliferation Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Glial Cell Fate Determination Oligodendrocyte Differentiation
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