MTA1 and SNAI1

Number of citations of the paper that reports this interaction (PubMedID 34026424)
83

Data Source:
BioGRID (pull down)

		MTA1	SNAI1
Description		metastasis associated 1	snail family transcriptional repressor 1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule NuRD Complex	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Kinase Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Signal Transduction Response To Ionizing Radiation Circadian Regulation Of Gene Expression Regulation Of Cell Fate Specification Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Positive Regulation Of Protein Autoubiquitination Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mesenchymal Cell Differentiation Roof Of Mouth Development Canonical Wnt Signaling Pathway Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly
Pathways		HDACs deacetylate histones SUMOylation of transcription factors ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Regulation of PTEN gene transcription Regulation of PTEN gene transcription Epithelial-Mesenchymal Transition (EMT) during gastrulation Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)	Psoriasis ( 20953189)
Interacting Genes		46 interacting genes: BLOC1S1 CCNH CSNK1G2 CYSRT1 DDX18 DYNLL1 DYRK1A E2F1 ERCC6 ESR1 FHL3 GPR183 GRB2 H3-4 HDAC1 HDAC2 HIF1A ITGB3BP JUN KHDRBS2 KPNA4 KRT31 KRT40 KRTAP10-8 LMO4 LRRK2 LZTS2 MAGEA11 MNAT1 NACC2 NBPF19 NELFCD NOTCH2NLA PICK1 PLEKHG4 RBBP4 SAT1 SH3GL1 SH3GLB1 SNAI1 SUMO2 TEX11 TP53 TRIM25 UBE2I ZEB2	49 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CREBBP CTDSP1 CTDSP2 CTDSPL DDB1 EFHC1 EIF3H EXOSC8 FBXO22 FBXO45 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KPNB1 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTA1 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RBX1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIP6 USP29 XRCC3
Entrez ID		9112	6615
HPRD ID		04633	05025
Ensembl ID		ENSG00000182979	ENSG00000124216
Uniprot IDs		E7ESY4 Q13330 Q9BRL8	O95863
PDB IDs		4BKX 4PBY 4PBZ 4PC0 5FXY 5ICN 6G16 6ZRC 6ZRD 7AO8 7AO9 7AOA	2Y48 3W5K 3ZMT 4QLI 8BOX 8F59 8FDV 8FJ7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Transcription Regulator Complex Regulation Of Fibroblast Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Eyelid Development In Camera-type Eye Regulation Of Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Enzyme Binding NuRD Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Transcription Factor TFIIK Complex Negative Regulation Of Macromolecule Metabolic Process Developmental Process Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Sin3-type Complex Negative Regulation Of Macromolecule Biosynthetic Process CAK-ERCC2 Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Stem Cell Population Maintenance Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Body Response To Oxidative Stress	Protein Modification Process Positive Regulation Of Signal Transduction Post-translational Protein Modification Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Deubiquitination RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Metabolic Process Regulation Of Mitotic Cell Cycle Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phosphatase Activity Positive Regulation Of Catabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Protein Ubiquitination Cul4A-RING E3 Ubiquitin Ligase Complex Protein Catabolic Process Telomere Maintenance Via Telomere Trimming Negative Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Mesenchymal Cell Differentiation Protein Polyubiquitination Response To Stress Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Phosphoprotein Phosphatase Activity Cytoplasm Negative Regulation Of Cell Communication
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