MTA1 and RBBP4

Number of citations of the paper that reports this interaction (PubMedID 12920132)
0

Data Source:
HPRD (in vitro)

		MTA1	RBBP4
Description		metastasis associated 1	RB binding protein 4, chromatin remodeling factor
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule NuRD Complex	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol NuRD Complex NURF Complex Protein-containing Complex CAF-1 Complex ESC/E(Z) Complex Sin3-type Complex ATPase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding ATP-dependent Activity, Acting On DNA Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Signal Transduction Response To Ionizing Radiation Circadian Regulation Of Gene Expression Regulation Of Cell Fate Specification Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Positive Regulation Of Protein Autoubiquitination Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Brain Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation
Pathways		HDACs deacetylate histones SUMOylation of transcription factors ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)
Interacting Genes		46 interacting genes: BLOC1S1 CCNH CSNK1G2 CYSRT1 DDX18 DYNLL1 DYRK1A E2F1 ERCC6 ESR1 FHL3 GPR183 GRB2 H3-4 HDAC1 HDAC2 HIF1A ITGB3BP JUN KHDRBS2 KPNA4 KRT31 KRT40 KRTAP10-8 LMO4 LRRK2 LZTS2 MAGEA11 MNAT1 NACC2 NBPF19 NELFCD NOTCH2NLA PICK1 PLEKHG4 RBBP4 SAT1 SH3GL1 SH3GLB1 SNAI1 SUMO2 TEX11 TP53 TRIM25 UBE2I ZEB2	59 interacting genes: AEBP2 ANXA7 ARMC12 BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP CYTOR DDB1 DHX30 ESR1 EXOSC8 FOXK2 H1-1 H2AC20 H3-4 H3C1 H3C14 H4C14 H4C16 HDAC1 HDAC2 HDAC3 HDAC4 HMOX2 ING1 KPNA5 LIN9 LMNA MBD2 MBD3 MTA1 MTA2 NR2E3 PRDM16 RB1 RBBP7 RBP1 RPN1 RPN2 RYBP SALL4 SAP30 SIN3A SMN1 SNCA SP1 SP3 SPEN STAT5B SUMO2 SUV39H1 TK1 TSSK3 USP7 XRCC6
Entrez ID		9112	5928
HPRD ID		04633	04232
Ensembl ID		ENSG00000182979	ENSG00000162521
Uniprot IDs		E7ESY4 Q13330 Q9BRL8	Q09028
PDB IDs		4BKX 4PBY 4PBZ 4PC0 5FXY 5ICN 6G16 6ZRC 6ZRD 7AO8 7AO9 7AOA	2XU7 3GFC 4PBY 4PBZ 4PC0 4R7A 5FXY 5VTB 5WAI 5WAK 5XWR 5XXQ 5Y1U 6BW3 6BW4 6C23 6C24 6G16 6NQ3 6WKR 6ZRC 6ZRD 7AOA 7KSO 7KSR 7KTP 7M40 7N40 7R1D 7Y5K 7Y5L 7Y5O 7Y5U 7Y5V 8EQV 8FYH 8IQF 8IQG 8T9G 8TAS 8TB9 8TX8 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Transcription Regulator Complex Regulation Of Fibroblast Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Eyelid Development In Camera-type Eye Regulation Of Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Enzyme Binding NuRD Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Transcription Factor TFIIK Complex Negative Regulation Of Macromolecule Metabolic Process Developmental Process Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Sin3-type Complex Negative Regulation Of Macromolecule Biosynthetic Process CAK-ERCC2 Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Stem Cell Population Maintenance Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Body Response To Oxidative Stress	Chromatin Remodeling Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Nucleus Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Heterochromatin Formation Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance DNA Binding Histone Deacetylase Complex NuRD Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Repressor Complex Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Rhythmic Process Chromatin Binding Positive Regulation Of Stem Cell Population Maintenance Regulation Of Macromolecule Metabolic Process Protein-containing Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Fate Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Stem Cell Population Maintenance Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Developmental Process Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Chromosome
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