SMYD3 and EED

Number of citations of the paper that reports this interaction (PMID 22659877)
26

Data Source:
BioGRID (unspecified method)

		SMYD3	EED
Gene Name		SET and MYND domain containing 3	embryonic ectoderm development
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Sex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm ESC/E(Z) Complex Pronucleus
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding	Chromatin Binding Protein Binding Histone Methyltransferase Activity Identical Protein Binding
	Biological Process	Chromatin Organization Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Dexamethasone Stimulus	Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Gene Expression Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K27 Methylation
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		16 interactors: APP CAMK2B CYP39A1 EED EZH2 H3F3C HELZ HIST3H3 HSP90AA1 NDUFAB1 NFYB PBX2 POLR2K TRIT1 VANGL1 ZNF557	38 interactors: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 HDAC1 HDAC2 HDAC3 HIST1H1A HIST1H3A ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PINK1 PJA1 PPP1CA PPP1R8 RBBP4 RPS10 SELENBP1 SMYD3 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42
Entrez ID		64754	8726
HPRD ID		12297	09343
Ensembl ID		ENSG00000185420	ENSG00000074266
Uniprot IDs		B3KN46 Q9H7B4	E9PJK2 O75530
PDB IDs		3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0	3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Inhibitory G-protein Coupled Receptor Phosphorylation Positive Regulation Of Cellular Metabolic Process Cellular Response To Heat Neuromuscular Process Controlling Balance Synaptic Growth At Neuromuscular Junction Activation Of Meiosis Involved In Egg Activation Innate Immune Response Regulation Of Synapse Structure Or Activity Cellular Metabolic Process Bile Acid Catabolic Process Collateral Sprouting In Absence Of Injury Response To Heat Transcription, DNA-templated Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Protein Import Into Mitochondrial Outer Membrane Activation Of Meiosis Cholesterol Metabolic Process Histone Methylation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Protein Lipoylation Sterol Metabolic Process Neuromuscular Process Regulation Of Cell Cycle Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Metabolic Process Gene Expression Regulation Of Synaptic Transmission, Cholinergic Axon Choice Point Recognition	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromosome Organization Chromatin Modification Negative Regulation Of Gene Expression DNA Methylation DNA Methylation On Cytosine Organelle Organization Negative Regulation Of Transcription, DNA-templated DNA Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation Histone H3-K27 Methylation DNA Metabolic Process Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Gene Silencing Positive Regulation Of Histone H3-K4 Methylation Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Histone Methylation Cell-matrix Adhesion Involved In Ameboidal Cell Migration Histone H4 Deacetylation Cellular Metabolic Process Regulation Of Histone H3-K4 Methylation Cellular Macromolecule Biosynthetic Process Circadian Regulation Of Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process
Tagcloud ?		blocked bovine conversely early embryonic embryos epigenetic fertilization germinal involves lysine mammalian maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Difference) ?		blocked bovine conversely early embryonic embryos epigenetic fertilization germinal involves lysine maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Intersection) ?		mammalian