SMYD3 and PBX2

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
HPRD (two hybrid)

		SMYD3	PBX2
Gene Name		SET and MYND domain containing 3	pre-B-cell leukemia homeobox 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Histone-lysine N-methyltransferase Activity Metal Ion Binding	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Chromatin Organization Nucleosome Assembly Negative Regulation Of Protein Kinase Activity Myotube Cell Development Positive Regulation Of Peptidyl-serine Phosphorylation Histone Lysine Methylation Establishment Of Protein Localization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Dexamethasone Stimulus	Transcription, DNA-templated Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Asthma ( 21804548) Crohn's disease ( 23266558) Prostate cancer ( 23535732)
Protein-Protein Interactions		16 interactors: APP CAMK2B CYP39A1 EED EZH2 H3F3C HELZ HIST3H3 HSP90AA1 NDUFAB1 NFYB PBX2 POLR2K TRIT1 VANGL1 ZNF557	21 interactors: BAIAP2 BLOC1S1 CARD9 CCDC88B CENPBD1 COPS6 DCTN3 HOXA1 HOXA9 HOXB8 IKBKAP MCRS1 NUP62 PBX1 PKNOX1 RPL4 RPS6KC1 SKIV2L2 SMYD3 UBE2E1 ZDHHC7
Entrez ID		64754	5089
HPRD ID		12297	08890
Ensembl ID		ENSG00000185420	ENSG00000204304
Uniprot IDs		B3KN46 Q9H7B4	P40425
PDB IDs		3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Inhibitory G-protein Coupled Receptor Phosphorylation Positive Regulation Of Cellular Metabolic Process Cellular Response To Heat Neuromuscular Process Controlling Balance Synaptic Growth At Neuromuscular Junction Activation Of Meiosis Involved In Egg Activation Innate Immune Response Regulation Of Synapse Structure Or Activity Cellular Metabolic Process Bile Acid Catabolic Process Collateral Sprouting In Absence Of Injury Response To Heat Transcription, DNA-templated Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Protein Import Into Mitochondrial Outer Membrane Activation Of Meiosis Cholesterol Metabolic Process Histone Methylation Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Protein Lipoylation Sterol Metabolic Process Neuromuscular Process Regulation Of Cell Cycle Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Metabolic Process Gene Expression Regulation Of Synaptic Transmission, Cholinergic Axon Choice Point Recognition	Embryonic Skeletal System Development RNA Biosynthetic Process Anterior/posterior Pattern Specification RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated Cellular Metabolic Process Pattern Specification Process Proximal/distal Pattern Formation Skeletal System Development Abducens Nerve Formation Optokinetic Behavior Immune System Process Peptidyl-lysine Modification Nucleobase-containing Compound Metabolic Process Embryonic Morphogenesis Negative Regulation Of Transferase Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Facial Nucleus Development Organelle Organization Cellular Protein Modification Process Chromatin Organization Negative Regulation Of Myeloid Cell Differentiation Cellular Nitrogen Compound Metabolic Process Viral Transcription Rhombomere 4 Development Semicircular Canal Formation Positive Regulation Of Cellular Metabolic Process Chordate Embryonic Development Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryo Development Ending In Birth Or Egg Hatching Regulation Of Nucleic Acid-templated Transcription Rhombomere 3 Development Rhombomere 5 Development Regulation Of RNA Biosynthetic Process Cellular Protein Metabolic Process Histone Modification Cellular Process Regulation Of RNA Metabolic Process Membrane Organization Peptidyl-L-cysteine S-palmitoylation Peptidyl-lysine Acetylation Endomembrane System Organization Embryonic Skeletal System Morphogenesis Nitrogen Compound Metabolic Process
Tagcloud ?		blocked bovine conversely early embryonic embryos epigenetic fertilization germinal involves lysine mammalian maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle	associate buds embryo embryonal embryonic endodermal extended half hox increases limb lives meis mrna mrnas p19 pbx1 pbx1a pbx1b pbx3 pbxs proteasome ra requiring stabilization subtype transcriptionally unspecific
Tagcloud (Difference) ?		blocked bovine conversely early embryos epigenetic fertilization germinal involves lysine mammalian maturation methyltransferase microinjection modifications mynd nanog oocyte oocytes plays program pronuclear regulates reprogramming sirna stage throughout vesicle	associate buds embryo embryonal endodermal extended half hox increases limb lives meis mrna mrnas p19 pbx1 pbx1a pbx1b pbx3 pbxs proteasome ra requiring stabilization subtype transcriptionally unspecific
Tagcloud (Intersection) ?		embryonic