SMYD3 and TRIT1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		SMYD3	TRIT1
Description		SET and MYND domain containing 3	tRNA isopentenyltransferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K4 Trimethyltransferase Activity	Nucleotide Binding Nucleic Acid Binding Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Metal Ion Binding TRNA Dimethylallyltransferase Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Myotube Cell Development Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus	TRNA Modification TRNA Processing Mitochondrial TRNA Modification
Pathways		PKMTs methylate histone lysines	tRNA modification in the nucleus and cytosol tRNA modification in the mitochondrion
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) DHEAS levels ( 34748635) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Malaria ( 31844061) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Renal underexcretion gout ( 32238385) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)	Refractive error ( 32231278)
Interacting Genes		25 interacting genes: APP CAMK2B CFTR CSTF2T CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 LCOR MAP3K2 MKRN3 NDUFAB1 NFYB NUP54 PBX2 PKN1 POLR2K RNF113A SHC3 TRIT1 VANGL1 ZNF557	6 interacting genes: AKT1 ANKS1A HGH1 OGT SHE SMYD3
Entrez ID		64754	54802
HPRD ID		12297	18226
Ensembl ID		ENSG00000185420	ENSG00000043514
Uniprot IDs		B3KN46 Q9H7B4	Q3T7C7 Q53F11 Q9H3H1
PDB IDs		3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL 6O9O 6P6G 6P6K 6P7Z 6PAF 6YUH 6ZRB 7BJ1 7O2A 7O2B 7O2C 7QLB 7QNR 7QNU 8OWO
Enriched GO Terms of Interacting Partners?		Nucleus Pronucleus Transcription Corepressor Binding Chromatin Silencing Complex	Positive Regulation Of Proteolysis Carbohydrate Homeostasis Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nitric-oxide Synthase Regulator Activity Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process TOR Signaling Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Protein Ubiquitination Response To Insulin-like Growth Factor Stimulus Cytoplasmic Translation Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Regulation Of Protein Localization To Cell Periphery Potassium Channel Activator Activity Regulation Of Protein Ubiquitination Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Response To UV Negative Regulation Of Translational Initiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Phosphatidylinositol-3,4,5-trisphosphate Binding Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Regulation Of Glucose Metabolic Process Response To Hormone Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of TOR Signaling Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Proteolysis Negative Regulation Of Translation TRNA (guanine-N7)-methylation Response To Ketone Activation-induced Cell Death Of T Cells Positive Regulation Of Translational Initiation Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Regulation Of Protein Localization To Membrane Response To Insulin Cellular Response To Rapamycin Positive Regulation Of Translation Peripheral Nervous System Myelin Maintenance
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