PARP2 and CENPA

Number of citations of the paper that reports this interaction (PubMedID 12217960)
0

Data Source:
HPRD (in vivo)

		PARP2	CENPA
Description		poly(ADP-ribose) polymerase 2	centromere protein A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Site Of DNA Damage	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nucleosome Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Cytosol CENP-A Containing Nucleosome CENP-A Containing Chromatin
	Molecular Function	DNA Binding Chromatin Binding Damaged DNA Binding Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Nucleosome Binding Poly-ADP-D-ribose Binding NAD DNA ADP-ribosyltransferase Activity NAD+-protein-serine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity Poly-ADP-D-ribose Modification-dependent Protein Binding NAD+-protein Mono-ADP-ribosyltransferase Activity	DNA Binding Chromatin Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair DNA Damage Response DNA ADP-ribosylation Decidualization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Chromatin Response To Oxygen-glucose Deprivation Extrinsic Apoptotic Signaling Pathway Hippocampal Neuron Apoptotic Process DNA Repair-dependent Chromatin Remodeling	Establishment Of Mitotic Spindle Orientation Mitotic Cytokinesis CENP-A Containing Chromatin Assembly Cell Division Kinetochore Assembly Protein Localization To CENP-A Containing Chromatin Protein Localization To Chromosome, Centromeric Region
Pathways		POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS		Menopause (age at onset) ( 26414677)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 UBC XRCC1	11 interacting genes: AURKB AURKC CDKN2A CUL4A DIAPH1 DIAPH2 H3C3 H4C6 HJURP PARP1 PARP2
Entrez ID		10038	1058
HPRD ID		09660	00313
Ensembl ID		ENSG00000129484	ENSG00000115163
Uniprot IDs		Q9UGN5	P49450
PDB IDs		3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N 7AEO 7R59 8HE8 8HKN 8HKO 8HKS 8HLJ 8HLQ 8JNY	3AN2 3NQJ 3NQU 3R45 3WTP 5CVD 5Z23 6BUZ 6C0W 6E0C 6E0P 6KDQ 6KDS 6L49 6MUO 6MUP 6O1D 6SE0 6SE6 6SEE 6SEF 6SEG 6TEM 7D20 7PII 7R5R 7U46 7U47 7U4D 7YWX 7YYH 9GXA
Enriched GO Terms of Interacting Partners?		Chromosome Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Chromatin Remodeling Nucleosome Organization Chromatin Organization Chromosome Organization Protein-DNA Complex Assembly Negative Regulation Of Chromosome Organization Nucleus Nucleoplasm Protein Localization To Chromosome Telomere Organization Regulation Of Base-excision Repair Negative Regulation Of DNA Metabolic Process Nucleosomal DNA Binding Site Of DNA Damage Protein Heterodimerization Activity DNA Binding Chromosome, Centromeric Region Protein Localization To Chromatin Regulation Of Protein ADP-ribosylation Chromosome, Telomeric Region Poly-ADP-D-ribose Binding Protein-containing Complex Assembly Regulation Of Chromosome Organization Protein-containing Complex Organization Protein Poly-ADP-ribosylation Condensed Chromosome, Centromeric Region Chromatin DNA Repair-dependent Chromatin Remodeling Regulation Of DNA Recombination Cellular Component Assembly Pericentric Heterochromatin Regulation Of Necroptotic Process Organelle Organization Nucleosome Binding Negative Regulation Of Telomere Maintenance Regulation Of Programmed Necrotic Cell Death Chromosome Condensation Protein Localization To Chromosome, Centromeric Region Chromatin Binding Regulation Of DNA Metabolic Process Macrophage Differentiation Double-strand Break Repair NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity	Chromosome Protein Localization To Chromosome NAD+-protein-serine ADP-ribosyltransferase Activity Protein Localization To Organelle DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Protein Localization To Chromatin Chromosome Passenger Complex Mitotic Spindle Midzone Assembly Organelle Organization Cellular Response To UV Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity Spindle Midzone Assembly NAD+-protein-aspartate ADP-ribosyltransferase Activity Chromatin Remodeling Cellular Response To Light Stimulus Negative Regulation Of CGAS/STING Signaling Pathway Protein Poly-ADP-ribosylation Telomere Organization NAD+-protein Mono-ADP-ribosyltransferase Activity Chromatin Organization Post-translational Protein Modification Decidualization DNA Repair-dependent Chromatin Remodeling DNA Modification Response To UV NAD+ Poly-ADP-ribosyltransferase Activity Chromosome, Centromeric Region Protein Serine/threonine/tyrosine Kinase Activity Spindle Midzone Kinetochore Cellular Response To Radiation Nucleolus Actin Filament Polymerization Nucleosome Binding Protein Modification Process Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Immune System Process Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Spindle Microtubule Site Of DNA Damage Positive Regulation Of Cytokinesis Intracellular Protein Localization Nucleus Spindle Positive Regulation Of Cell Cycle Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
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