PARP2 and H2BC4

Number of citations of the paper that reports this interaction (PubMedID 28190768)
48

Data Source:
BioGRID (enzymatic study)

		PARP2	H2BC4
Description		poly(ADP-ribose) polymerase 2	H2B clustered histone 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Site Of DNA Damage	Nucleosome Extracellular Space Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Damaged DNA Binding Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Nucleosome Binding Poly-ADP-D-ribose Binding NAD DNA ADP-ribosyltransferase Activity NAD+-protein-serine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity Poly-ADP-D-ribose Modification-dependent Protein Binding NAD+-protein Mono-ADP-ribosyltransferase Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair DNA Damage Response DNA ADP-ribosylation Decidualization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Chromatin Response To Oxygen-glucose Deprivation Extrinsic Apoptotic Signaling Pathway Hippocampal Neuron Apoptotic Process DNA Repair-dependent Chromatin Remodeling	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs		Veliparib Olaparib Talazoparib Niraparib Rucaparib	Copper
Diseases
GWAS		Menopause (age at onset) ( 26414677)	Skin and soft tissue infections ( 33662382)
Interacting Genes		14 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 UBC XRCC1	6 interacting genes: AP2M1 ESR1 HPF1 PARP1 PARP2 TP53BP2
Entrez ID		10038	8347
HPRD ID		09660	13656
Ensembl ID		ENSG00000129484	ENSG00000180596
Uniprot IDs		Q9UGN5	B2R4S9 P62807
PDB IDs		3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N 7AEO 7R59 8HE8 8HKN 8HKO 8HKS 8HLJ 8HLQ 8JNY	5GT0 5KGF 6ACO 6C0W 6FML 6R0C 6RNY 6SE0 6SE6 6SEE 6SEF 6SEG 6UPK 6UPL 6X59 6X5A 6XJD 7A08 7JO9 7JOA 7PII 7R5R 7TAN 7TRF 7U46 7U47 7U4D 7U50 7U51 7U52 7U53 7UV9 7Y8R 7YWX 7YYH 8ATF 8AV6 8JBX 8OFF 8OO7 8OOA 8OOP 8OOS 8OX0 8OX1 8QZM 8TXV 8TXW 8TXX 8U13 8VWS 8VWT 8VWU 8VWV 8X15 8X19 8X1C 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9EOZ
Enriched GO Terms of Interacting Partners?		Chromosome Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Chromatin Remodeling Nucleosome Organization Chromatin Organization Chromosome Organization Protein-DNA Complex Assembly Negative Regulation Of Chromosome Organization Nucleus Nucleoplasm Protein Localization To Chromosome Telomere Organization Regulation Of Base-excision Repair Negative Regulation Of DNA Metabolic Process Nucleosomal DNA Binding Site Of DNA Damage Protein Heterodimerization Activity DNA Binding Chromosome, Centromeric Region Protein Localization To Chromatin Regulation Of Protein ADP-ribosylation Chromosome, Telomeric Region Poly-ADP-D-ribose Binding Protein-containing Complex Assembly Regulation Of Chromosome Organization Protein-containing Complex Organization Protein Poly-ADP-ribosylation Condensed Chromosome, Centromeric Region Chromatin DNA Repair-dependent Chromatin Remodeling Regulation Of DNA Recombination Cellular Component Assembly Pericentric Heterochromatin Regulation Of Necroptotic Process Organelle Organization Nucleosome Binding Negative Regulation Of Telomere Maintenance Regulation Of Programmed Necrotic Cell Death Chromosome Condensation Protein Localization To Chromosome, Centromeric Region Chromatin Binding Regulation Of DNA Metabolic Process Macrophage Differentiation Double-strand Break Repair NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity	Protein Localization To Chromatin Protein Localization To Chromosome Protein Poly-ADP-ribosylation DNA Repair-dependent Chromatin Remodeling NAD+-protein-serine ADP-ribosyltransferase Activity DNA ADP-ribosylation Site Of DNA Damage NAD DNA ADP-ribosyltransferase Activity Poly-ADP-D-ribose Binding Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Chromatin Binding NAD+-protein Mono-ADP-ribosyltransferase Activity Decidualization Protein Localization To Organelle Chromatin Remodeling NAD+ Poly-ADP-ribosyltransferase Activity DNA Modification Double-strand Break Repair Nucleosome Binding Positive Regulation Of Cardiac Muscle Hypertrophy Intracellular Protein Localization Nuclear Estrogen Receptor Binding Chromatin Organization Damaged DNA Binding Regulation Of Cardiac Muscle Hypertrophy NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Nucleotidyltransferase Activity DNA Repair Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of ATP Biosynthetic Process Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Hippocampal Neuron Apoptotic Process Chromosome Regulation Of Base-excision Repair ATP Generation From Poly-ADP-D-ribose Signal Sequence Binding Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Protein ADP-ribosyltransferase-substrate Adaptor Activity DNA Metabolic Process Transcription Pausing By RNA Polymerase II
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