PARP2 and CENPB

Number of citations of the paper that reports this interaction (PubMedID 12217960)
0

Data Source:
HPRD (in vivo)

		PARP2	CENPB
Description		poly(ADP-ribose) polymerase 2	centromere protein B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Site Of DNA Damage	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nuclear Body
	Molecular Function	DNA Binding Chromatin Binding Damaged DNA Binding Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Nucleosome Binding Poly-ADP-D-ribose Binding NAD DNA ADP-ribosyltransferase Activity NAD+-protein-serine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity Poly-ADP-D-ribose Modification-dependent Protein Binding NAD+-protein Mono-ADP-ribosyltransferase Activity	Nucleic Acid Binding DNA Binding Chromatin Binding Satellite DNA Binding Protein Binding Centromeric DNA Binding Sequence-specific DNA Binding
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair DNA Damage Response DNA ADP-ribosylation Decidualization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Chromatin Response To Oxygen-glucose Deprivation Extrinsic Apoptotic Signaling Pathway Hippocampal Neuron Apoptotic Process DNA Repair-dependent Chromatin Remodeling
Pathways		POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs		Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS		Menopause (age at onset) ( 26414677)
Interacting Genes		14 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 UBC XRCC1	20 interacting genes: ADRB2 ANXA7 APP CDKN1A CENPW FBXO25 GADD45A GFI1B GSK3B HAND2 NR3C1 PARP1 PARP2 PIN1 RPS6KA6 SH2D3A SMN1 TAC1 TADA3 TK1
Entrez ID		10038	1059
HPRD ID		09660	00314
Ensembl ID		ENSG00000129484	ENSG00000125817
Uniprot IDs		Q9UGN5	P07199
PDB IDs		3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N 7AEO 7R59 8HE8 8HKN 8HKO 8HKS 8HLJ 8HLQ 8JNY	1BW6 1HLV 1UFI 6KDR
Enriched GO Terms of Interacting Partners?		Chromosome Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Chromatin Remodeling Nucleosome Organization Chromatin Organization Chromosome Organization Protein-DNA Complex Assembly Negative Regulation Of Chromosome Organization Nucleus Nucleoplasm Protein Localization To Chromosome Telomere Organization Regulation Of Base-excision Repair Negative Regulation Of DNA Metabolic Process Nucleosomal DNA Binding Site Of DNA Damage Protein Heterodimerization Activity DNA Binding Chromosome, Centromeric Region Protein Localization To Chromatin Regulation Of Protein ADP-ribosylation Chromosome, Telomeric Region Poly-ADP-D-ribose Binding Protein-containing Complex Assembly Regulation Of Chromosome Organization Protein-containing Complex Organization Protein Poly-ADP-ribosylation Condensed Chromosome, Centromeric Region Chromatin DNA Repair-dependent Chromatin Remodeling Regulation Of DNA Recombination Cellular Component Assembly Pericentric Heterochromatin Regulation Of Necroptotic Process Organelle Organization Nucleosome Binding Negative Regulation Of Telomere Maintenance Regulation Of Programmed Necrotic Cell Death Chromosome Condensation Protein Localization To Chromosome, Centromeric Region Chromatin Binding Regulation Of DNA Metabolic Process Macrophage Differentiation Double-strand Break Repair NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity	Cellular Response To Amyloid-beta Response To Amyloid-beta NAD+-protein-serine ADP-ribosyltransferase Activity Neuronal Dense Core Vesicle DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Nucleus Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Chromatin Organization Regulation Of Developmental Process Positive Regulation Of Programmed Cell Death Regulation Of System Process Regulation Of Protein Localization To Nucleus Regulation Of Multicellular Organismal Process Regulation Of Developmental Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Protein Auto-ADP-ribosylation Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Neuron Apoptotic Process Antifungal Humoral Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cardiac Muscle Hypertrophy NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of MAPK Cascade Negative Regulation Of Macromolecule Biosynthetic Process NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Intracellular Signal Transduction Regulation Of Membrane Potential Response To Yeast Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Cycle Regulation Of Muscle System Process Protein Poly-ADP-ribosylation Regulation Of Neuron Apoptotic Process Regulation Of Transcription By RNA Polymerase II Response To Lipid NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Mitotic Cell Cycle Negative Regulation Of Systemic Arterial Blood Pressure
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