PARP2 and BUB3

Number of citations of the paper that reports this interaction (PubMedID 12217960)
0

Data Source:
HPRD (in vivo)

		PARP2	BUB3
Description		poly(ADP-ribose) polymerase 2	BUB3 mitotic checkpoint protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Site Of DNA Damage	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex
	Molecular Function	DNA Binding Chromatin Binding Damaged DNA Binding Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Nucleosome Binding Poly-ADP-D-ribose Binding NAD DNA ADP-ribosyltransferase Activity NAD+-protein-serine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity Poly-ADP-D-ribose Modification-dependent Protein Binding NAD+-protein Mono-ADP-ribosyltransferase Activity	Protein Binding Ubiquitin Binding
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair DNA Damage Response DNA ADP-ribosylation Decidualization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Chromatin Response To Oxygen-glucose Deprivation Extrinsic Apoptotic Signaling Pathway Hippocampal Neuron Apoptotic Process DNA Repair-dependent Chromatin Remodeling	Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Chromosome Segregation
Pathways		POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS		Menopause (age at onset) ( 26414677)	Body mass index ( 28892062) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Left-handedness ( 32989287) Lung volume ( 34128465) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)
Interacting Genes		14 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 UBC XRCC1	20 interacting genes: ANXA1 BUB1 BUB1B CEBPA CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 REXO4 RPL37A SUGT1 THRA TOP1 UBA1 WBP4
Entrez ID		10038	9184
HPRD ID		09660	04761
Ensembl ID		ENSG00000129484	ENSG00000154473
Uniprot IDs		Q9UGN5	A0A140VJF3 O43684
PDB IDs		3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N 7AEO 7R59 8HE8 8HKN 8HKO 8HKS 8HLJ 8HLQ 8JNY
Enriched GO Terms of Interacting Partners?		Chromosome Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Chromatin Remodeling Nucleosome Organization Chromatin Organization Chromosome Organization Protein-DNA Complex Assembly Negative Regulation Of Chromosome Organization Nucleus Nucleoplasm Protein Localization To Chromosome Telomere Organization Regulation Of Base-excision Repair Negative Regulation Of DNA Metabolic Process Nucleosomal DNA Binding Site Of DNA Damage Protein Heterodimerization Activity DNA Binding Chromosome, Centromeric Region Protein Localization To Chromatin Regulation Of Protein ADP-ribosylation Chromosome, Telomeric Region Poly-ADP-D-ribose Binding Protein-containing Complex Assembly Regulation Of Chromosome Organization Protein-containing Complex Organization Protein Poly-ADP-ribosylation Condensed Chromosome, Centromeric Region Chromatin DNA Repair-dependent Chromatin Remodeling Regulation Of DNA Recombination Cellular Component Assembly Pericentric Heterochromatin Regulation Of Necroptotic Process Organelle Organization Nucleosome Binding Negative Regulation Of Telomere Maintenance Regulation Of Programmed Necrotic Cell Death Chromosome Condensation Protein Localization To Chromosome, Centromeric Region Chromatin Binding Regulation Of DNA Metabolic Process Macrophage Differentiation Double-strand Break Repair NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity	Nucleoplasm Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway NAD+-protein-serine ADP-ribosyltransferase Activity Nucleus NuRD Complex DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Sin3-type Complex Protein Lysine Delactylase Activity Negative Regulation Of Stem Cell Population Maintenance Regulation Of Cell Fate Specification Fungiform Papilla Formation Chromatin Remodeling Meiotic Sister Chromatid Cohesion, Centromeric NF-kappaB Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Intracellular Estrogen Receptor Signaling Pathway Chromatin Binding Hair Follicle Placode Formation Histone Deacetylase Binding Histone Deacetylase Complex Circadian Rhythm Macromolecule Metabolic Process Regulation Of Cell Fate Commitment Regulation Of Cell Differentiation Positive Regulation Of Stem Cell Population Maintenance Response To Temperature Stimulus Chromatin Organization Chromosome Organization Positive Regulation Of Cell Differentiation Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Circadian Regulation Of Gene Expression Protein Auto-ADP-ribosylation Positive Regulation Of Developmental Process Meiotic Sister Chromatid Cohesion Cytosol NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of Stem Cell Population Maintenance Response To Steroid Hormone NAD+-protein-aspartate ADP-ribosyltransferase Activity Protein Lysine Deacetylase Activity Negative Regulation Of Chromosome Organization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Regulation Of Stem Cell Differentiation Eyelid Development In Camera-type Eye Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
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