Wiki-Pi
About
Search
People
Updates
Search
GRIA1 and CASP8
Number of citations of the paper that reports this interaction (PubMedID
11751897
)
0
Data Source:
HPRD
(in vivo)
GRIA1
CASP8
Description
glutamate ionotropic receptor AMPA type subunit 1
caspase 8
Image
GO Annotations
Cellular Component
Endosome
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Cell-cell Junction
Synaptic Vesicle
Ionotropic Glutamate Receptor Complex
External Side Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Postsynaptic Density
Membrane
Dendrite
Endocytic Vesicle Membrane
Synaptic Vesicle Membrane
Neuromuscular Junction
Early Endosome Membrane
Asymmetric Synapse
AMPA Glutamate Receptor Complex
Dendrite Membrane
Dendritic Spine Membrane
Neuronal Cell Body Membrane
Protein-containing Complex
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Somatodendritic Compartment
Presynaptic Membrane
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Dendritic Shaft
Cell Body
Axonal Spine
Neuron Spine
Synapse
Postsynaptic Membrane
Presynaptic Active Zone Membrane
Recycling Endosome
Recycling Endosome Membrane
Excitatory Synapse
Synaptic Membrane
Presynapse
Postsynapse
Postsynaptic Density Membrane
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Perisynaptic Space
Proximal Dendrite
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Cytoskeleton
Plasma Membrane
Lamellipodium
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Protein-containing Complex
Cell Projection
Cell Body
Ripoptosome
Molecular Function
Amyloid-beta Binding
G-protein Alpha-subunit Binding
Glutamate-gated Receptor Activity
AMPA Glutamate Receptor Activity
Monoatomic Ion Channel Activity
Protein Binding
Adenylate Cyclase Binding
Ligand-gated Monoatomic Ion Channel Activity
Immunoglobulin Binding
Protein Kinase Binding
Protein Domain Specific Binding
Glutamate-gated Calcium Ion Channel Activity
PDZ Domain Binding
Small GTPase Binding
Myosin V Binding
G-protein Beta-subunit Binding
Beta-2 Adrenergic Receptor Binding
Glutamate Receptor Binding
Signaling Receptor Activity
Identical Protein Binding
Protein Kinase A Binding
Peptide Hormone Receptor Binding
Scaffold Protein Binding
Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
Cysteine-type Endopeptidase Activity
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Scaffold Protein Binding
Biological Process
Regulation Of Receptor Recycling
Monoatomic Ion Transport
Signal Transduction
Chemical Synaptic Transmission
Synapse Assembly
Long-term Memory
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Sucrose
Response To Lithium Ion
Positive Regulation Of Gene Expression
Neuronal Action Potential
Calcium-mediated Signaling
Spinal Cord Development
Cerebral Cortex Development
Receptor Internalization
Response To Nutrient Levels
Response To Estradiol
Monoatomic Ion Transmembrane Transport
Regulation Of Monoatomic Ion Transmembrane Transport
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Response To Cocaine
Response To Morphine
Response To Peptide Hormone
Response To Ethanol
Positive Regulation Of Membrane Potential
Response To Arsenic-containing Substance
Regulation Of Synaptic Plasticity
Behavioral Response To Pain
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Synaptic Transmission
Response To Electrical Stimulus
Regulation Of Postsynaptic Membrane Potential
Long-term Synaptic Potentiation
Long-term Synaptic Depression
Response To Fungicide
Cellular Response To Amino Acid Stimulus
Cellular Response To Ammonium Ion
Cellular Response To DsRNA
Cellular Response To Growth Factor Stimulus
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Amine Stimulus
Positive Regulation Of Locomotion Involved In Locomotory Behavior
Regulation Of Presynaptic Membrane Potential
Cellular Response To L-glutamate
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Conditioned Place Preference
Response To Psychosocial Stress
Positive Regulation Of Excitatory Postsynaptic Potential
Autophagosome Assembly
Angiogenesis
Regulation Of Cytokine Production
Regulation Of Immune System Process
Proteolysis
Apoptotic Process
Heart Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Signal Transduction
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Processing
Natural Killer Cell Activation
Cell Differentiation
Macrophage Differentiation
Positive Regulation Of Cell Migration
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Beta Production
Response To Tumor Necrosis Factor
TRAIL-activated Apoptotic Signaling Pathway
T Cell Activation
B Cell Activation
Regulation Of Apoptotic Process
Chordate Embryonic Development
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Innate Immune Response
Response To Ethanol
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Animal Organ Development
Proteolysis Involved In Protein Catabolic Process
Protein Maturation
Negative Regulation Of Necroptotic Process
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Pyroptotic Inflammatory Response
Cellular Response To Mechanical Stimulus
Response To Anesthetic
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Self Proteolysis
Positive Regulation Of Pyroptotic Inflammatory Response
Positive Regulation Of Execution Phase Of Apoptosis
Pathways
COPII-mediated vesicle transport
Activation of AMPA receptors
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Cargo concentration in the ER
Synaptic adhesion-like molecules
Long-term potentiation
Apoptotic cleavage of cellular proteins
Caspase activation via Death Receptors in the presence of ligand
NOD1/2 Signaling Pathway
TRIF-mediated programmed cell death
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
Activation, myristolyation of BID and translocation to mitochondria
Apoptotic execution phase
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Microbial modulation of RIPK1-mediated regulated necrosis
Defective RIPK1-mediated regulated necrosis
Regulation of NF-kappa B signaling
Drugs
Glutamic acid
Butabarbital
Lamotrigine
Isoflurane
Ethanol
Methoxyflurane
Desflurane
Sevoflurane
Talampanel
CX-717
CX516
Perampanel
Tianeptine
Fluciclovine (18F)
Trichostatin A
AN-9
Bryostatin 1
Bardoxolone
Oleandrin
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Adult body size (
32376654
)
Aging (time to event) (
21782286
)
Anthropometric traits (
19260139
)
Asparaginase hypersensitivity in acute lymphoblastic leukemia (
20592726
)
Chronotype (
30696823
)
General risk tolerance (MTAG) (
30643258
)
Hand grip strength (
29691431
)
HDL cholesterol levels (
32203549
)
Interleukin-6 levels (
22205395
)
Middle childhood and early adolescence aggressive behavior (
26087016
)
Morning person (
30696823
)
Obesity-related traits (
23251661
)
Post bronchodilator FEV1 in COPD (
26634245
)
Schizophrenia (
30285260
28991256
25056061
23974872
)
Sleep (1/3-day periodicity) (
33075057
)
Sudden cardiac arrest (
21658281
)
Survival in microsatellite instability low/stable colorectal cancer (
25866641
)
Basal cell carcinoma (
33549134
25855136
28177523
)
Breast cancer (
29059683
)
Chronic lymphocytic leukemia (
23770605
26956414
28165464
)
Cutaneous malignant melanoma (
32341527
)
Esophageal squamous cell carcinoma (
25129146
)
Lymphocyte count (
27863252
)
Melanoma (
28212542
21983787
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of white cells (
32888494
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Non-small cell lung cancer (
31326317
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
)
Rheumatoid arthritis (
30423114
24390342
)
Spleen volume (
34128465
)
White blood cell count (
32888494
)
Interacting Genes
27 interacting genes:
CACNG2
CAMK2A
CAMK2G
CANX
CASP8
CXCR2
CYLD
DLG1
EPB41L1
EPB41L2
GRIA4
GRID2
GRIK2
GRIP1
GRIPAP1
HOMER1
HSPA5
NEDD4L
PICK1
PRKACA
PRKCA
RPS6KB1
SDCBP
SQSTM1
TANC1
TRPC1
USP46
133 interacting genes:
AGR3
ANGPTL4
AP1M1
APAF1
APP
AR
ATAD2
ATG4D
ATP1A3
BAP1
BCAP31
BCL2
BCL2L1
BCL2L10
BEX1
BFAR
BID
BIRC6
BLID
BRD1
CASC3
CASP1
CASP10
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8AP2
CASP9
CCNL1
CDH1
CDH13
CDK11B
CDKN1B
CFLAR
CHD3
CHUK
CNBP
COPS6
CRADD
CTNNB1
DEDD
DEDD2
EDA2R
EIF2AK2
EPSTI1
ERRFI1
FADD
FAF1
FAS
FYN
GLCE
GMEB1
GREB1
GRIA1
GZMB
HBP1
HDAC7
HECTD3
HIP1
IKBKB
IKBKG
IL13RA2
IL24
ILK
KLK5
KLK9
KRT18
LYPD3
MAP1LC3B
MAP3K14
MAP4K4
MAPK1
MAPK3
MAPT
NOD1
NOL3
NR1H4
NSD3
OGT
PARK7
PARP1
PARP2
PCYT1A
PDIA6
PEA15
PIAS1
PICALM
PIK3C3
PLA2G4B
PLEC
PLIN4
PRDM14
PRDX6
PRKCI
PRKCZ
PRKN
PRSS50
PSEN1
PSEN2
PSMC3IP
QDPR
RALBP1
RB1
RIPK1
RIPK2
RNF31
RYBP
S100A14
SCGB2A2
SERPINB5
SNRPD3
SOX2
SRC
SRF
ST14
STK24
SUMO1
TFCP2
TNFRSF10A
TNFRSF10B
TOPORS
TRAF1
TRAF2
UBC
UMPS
USO1
VIM
VPS45
YBX1
ZNF707
Entrez ID
2890
841
HPRD ID
00695
03459
Ensembl ID
ENSG00000155511
ENSG00000064012
Uniprot IDs
A0A9L9PXG3
P42261
Q59GL5
A0A8Q3SID9
Q14790
PDB IDs
6X5Q
1F9E
1I4E
1QDU
1QTN
2C2Z
2FUN
2K7Z
2Y1L
3H11
3KJN
3KJQ
4JJ7
4PRZ
4PS1
4ZBW
5H31
5H33
5JQE
5L08
6AGW
6PX9
7DEE
7LVJ
7LVM
8YBX
8YD7
8YD8
8YM4
8YM5
8YM6
8YNI
8YNK
8YNL
8YNM
8YNN
Enriched GO Terms of Interacting Partners
?
Synapse
Modulation Of Chemical Synaptic Transmission
Glutamatergic Synapse
Regulation Of Protein Localization To Cell Periphery
Postsynaptic Density
Regulation Of Protein Localization
Neuron Projection
Regulation Of Cell Communication
Regulation Of Signaling
Endocytic Vesicle Membrane
Ionotropic Glutamate Receptor Binding
Regulation Of Transport
Regulation Of Protein Localization To Membrane
Regulation Of Biological Quality
Postsynaptic Density Membrane
Regulation Of Synaptic Plasticity
Plasma Membrane
Regulation Of Apoptotic Process
Regulation Of Metal Ion Transport
Regulation Of Programmed Cell Death
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cellular Component Organization
Glutamate Receptor Signaling Pathway
Positive Regulation Of Synaptic Transmission
Regulation Of Monoatomic Ion Transport
Positive Regulation Of Transport
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Protein Localization
Intracellular Signaling Cassette
Dendrite
Positive Regulation Of Protein Localization To Cell Periphery
Negative Regulation Of Programmed Cell Death
Intracellular Protein Localization
Proteolysis Involved In Protein Catabolic Process
Proteolysis
Chemical Synaptic Transmission
AMPA Glutamate Receptor Complex
Trans-synaptic Signaling
Cortical Actin Cytoskeleton Organization
Ionotropic Glutamate Receptor Signaling Pathway
Ionotropic Glutamate Receptor Complex
Regulation Of Cellular Localization
Protein Phosphorylation
Synaptic Signaling
Establishment Of Protein Localization
Protein Localization To Postsynaptic Membrane
Ligand-gated Monoatomic Ion Channel Activity
Protein Localization To Postsynapse
Programmed Cell Death
Cell Death
Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Apoptotic Signaling Pathway
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Apoptotic Process
Intracellular Signal Transduction
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction
Positive Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Extrinsic Apoptotic Signaling Pathway
Signal Transduction
Negative Regulation Of Programmed Cell Death
Cellular Response To Stress
Response To Stress
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Process
Cytosol
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Neuron Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Neuron Apoptotic Process
Cytoplasm
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cellular Response To Oxygen-containing Compound
Ubiquitin Protein Ligase Binding
Intrinsic Apoptotic Signaling Pathway
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cysteine-type Endopeptidase Activity
Protein Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Programmed Necrotic Cell Death
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?