GRIA1 and CACNG2

Number of citations of the paper that reports this interaction (PMID 11140673)
222

Data Source:
HPRD (in vivo)

		GRIA1	CACNG2
Gene Name		glutamate receptor, ionotropic, AMPA 1	calcium channel, voltage-dependent, gamma subunit 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Cell Junction Dendrite Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Membrane Dendritic Spine Membrane Neuronal Cell Body Dendritic Spine Axonal Spine Neuron Spine Postsynaptic Membrane Recycling Endosome	Plasma Membrane Voltage-gated Calcium Channel Complex Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex
	Molecular Function	Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding Glutamate Receptor Activity PDZ Domain Binding	Voltage-gated Calcium Channel Activity Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Signal Transduction Synaptic Transmission Long-term Memory Receptor Internalization Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Long Term Synaptic Depression	Transport Synaptic Transmission Neuromuscular Junction Development Transmission Of Nerve Impulse Membrane Depolarization Membrane Hyperpolarization Calcium Ion Transmembrane Transport Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways		Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Enflurane Isoflurane Methoxyflurane Desflurane Sevoflurane Perampanel
Diseases
GWAS		Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		22 interactors: CACNG2 CAMK2G CANX CASP8 CXCR2 DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 PICK1 PRKACA PRKCA SDCBP SQSTM1 TANC1 TRPC1	10 interactors: APP DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA4 INADL PRKACA SRPK2
Entrez ID		2890	10369
HPRD ID		00695	04220
Ensembl ID		ENSG00000155511
Uniprot IDs		P42261 Q59GL5	Q9Y698
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Response To External Stimulus Positive Regulation Of Macrophage Differentiation Glutamate Receptor Signaling Pathway Protein Localization Cortical Actin Cytoskeleton Organization Positive Regulation Of Dense Core Granule Biogenesis Developmental Process Cortical Cytoskeleton Organization Cell Differentiation Nervous System Development Histone H3-T6 Phosphorylation Positive Regulation Of Transport Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Programmed Cell Death Neutrophil Chemotaxis Chemotaxis Anatomical Structure Development Apoptotic Signaling Pathway Receptor Clustering System Development Neutrophil Migration Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Ion Transport Negative Regulation Of Cell Death Granulocyte Chemotaxis Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Anatomical Structure Morphogenesis Intrinsic Apoptotic Signaling Pathway Cell Activation Regulation Of Cellular Localization Regulation Of Apoptotic Process Regulation Of Calcium Ion Transport Cellular Metal Ion Homeostasis Neuron-neuron Synaptic Transmission Regulation Of Signaling Signal Transduction Dendritic Spine Maintenance Response To Cytokine Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Death	Receptor Localization To Synapse Protein Localization To Synapse Synaptic Transmission Receptor Clustering Nucleotide Phosphorylation Cell-cell Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Signaling Ionotropic Glutamate Receptor Signaling Pathway Cell Communication Phosphorylation Glutamate Receptor Signaling Pathway Chemotaxis Signal Transduction Protein Localization To Membrane Membrane Organization Axon Guidance Cell-cell Junction Assembly Response To Stimulus Phosphate-containing Compound Metabolic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cellular Component Assembly Axonogenesis Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Axon Development Cortical Cytoskeleton Organization Cell Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Cellular Response To Stimulus Cell-cell Junction Organization Locomotion Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Nervous System Development Small Molecule Metabolic Process Synaptic Transmission, Glutamatergic Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Learning Or Memory Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Tight Junction Assembly Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Cycle Cognition Negative Regulation Of Catalytic Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis
Tagcloud ?		acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley	ampa bioinformatics electrophysiological glutamatergic hypomorphic inbred integrative intimately list mapped narrow neuropathic pain1 physiology pinpoint precipitating predisposing predisposition progeny psychosocial qtl rist rpt segregation specifics stargazer stargazin trait ultimately
Tagcloud (Difference) ?		acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley	ampa bioinformatics electrophysiological glutamatergic hypomorphic inbred integrative intimately list mapped narrow neuropathic pain1 physiology pinpoint precipitating predisposing predisposition progeny psychosocial qtl rist rpt segregation specifics stargazer stargazin trait ultimately
Tagcloud (Intersection) ?