GRIA1 and GRID2

Number of citations: 0 (PubMedID 12573530)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		GRIA1	GRID2
Name		glutamate ionotropic receptor AMPA type subunit 1	glutamate ionotropic receptor delta type subunit 2
Structure
GO Annotations	Cellular Component	Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell-cell Junction Synaptic Vesicle Ionotropic Glutamate Receptor Complex External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Postsynaptic Density Membrane Dendrite Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuromuscular Junction Early Endosome Membrane Asymmetric Synapse AMPA Glutamate Receptor Complex Dendrite Membrane Dendritic Spine Membrane Neuronal Cell Body Membrane Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Somatodendritic Compartment Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Cell Body Axonal Spine Neuron Spine Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Synaptic Membrane Presynapse Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component Perisynaptic Space Proximal Dendrite	Plasma Membrane Ionotropic Glutamate Receptor Complex Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Trans-synaptic Protein Complex Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Amyloid-beta Binding G-protein Alpha-subunit Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Adenylate Cyclase Binding Ligand-gated Monoatomic Ion Channel Activity Immunoglobulin Binding Protein Kinase Binding Protein Domain Specific Binding Glutamate-gated Calcium Ion Channel Activity PDZ Domain Binding Small GTPase Binding Myosin V Binding G-protein Beta-subunit Binding Beta-2 Adrenergic Receptor Binding Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding Protein Kinase A Binding Peptide Hormone Receptor Binding Scaffold Protein Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Regulation Of Receptor Recycling Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Synapse Assembly Long-term Memory Response To Xenobiotic Stimulus Response To Toxic Substance Response To Sucrose Response To Lithium Ion Positive Regulation Of Gene Expression Neuronal Action Potential Calcium-mediated Signaling Spinal Cord Development Cerebral Cortex Development Receptor Internalization Response To Nutrient Levels Response To Estradiol Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Cocaine Response To Morphine Response To Peptide Hormone Response To Ethanol Positive Regulation Of Membrane Potential Response To Arsenic-containing Substance Regulation Of Synaptic Plasticity Behavioral Response To Pain Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Response To Electrical Stimulus Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Potentiation Long-term Synaptic Depression Response To Fungicide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To DsRNA Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Amine Stimulus Positive Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Presynaptic Membrane Potential Cellular Response To L-glutamate Cellular Response To Brain-derived Neurotrophic Factor Stimulus Conditioned Place Preference Response To Psychosocial Stress Positive Regulation Of Excitatory Postsynaptic Potential	Monoatomic Ion Transport Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Intracellular Protein Localization Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Prepulse Inhibition Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Density Assembly Synaptic Signaling Via Neuropeptide Positive Regulation Of Long-term Synaptic Depression Excitatory Synapse Assembly Regulation Of Presynapse Assembly
Pathways		COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules Long-term potentiation	None
Drugs		Glutamic acid Butabarbital Lamotrigine Isoflurane Ethanol Methoxyflurane Desflurane Sevoflurane Talampanel CX-717 CX516 Perampanel Tianeptine Fluciclovine (18F)	None
GWAS		Adult body size ( 32376654 ) Aging (time to event) ( 21782286 ) Anthropometric traits ( 19260139 ) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726 ) Chronotype ( 30696823 ) General risk tolerance (MTAG) ( 30643258 ) Hand grip strength ( 29691431 ) HDL cholesterol levels ( 32203549 ) Interleukin-6 levels ( 22205395 ) Middle childhood and early adolescence aggressive behavior ( 26087016 ) Morning person ( 30696823 ) Obesity-related traits ( 23251661 ) Post bronchodilator FEV1 in COPD ( 26634245 ) Schizophrenia ( 30285260 28991256 25056061 23974872 ) Sleep (1/3-day periodicity) ( 33075057 ) Sudden cardiac arrest ( 21658281 ) Survival in microsatellite instability low/stable colorectal cancer ( 25866641 )	Coffee consumption ( 31046077 ) Intelligence (MTAG) ( 29326435 ) Manganese levels ( 26025379 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Obsessive-compulsive disorder ( 30456828 ) Obsessive-compulsive traits ( 33531474 ) Pancreatic beta-cell glucose sensitivity ( 32944759 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Smoking initiation ( 33082346 )
Novel Interactors		1 novel interactors: FLT4	None recorded
Interacting Genes		27 interacting genes: CACNG2 CAMK2A CAMK2G CANX CASP8 CXCR2 CYLD DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 NEDD4L PICK1 PRKACA PRKCA RPS6KB1 SDCBP SQSTM1 TANC1 TRPC1 USP46	10 interacting genes: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4
Entrez ID		2890	2895
HPRD ID		00695	06781
Ensembl ID		ENSG00000155511	ENSG00000152208
Uniprot IDs		A0A9L9PXG3 P42261 Q59GL5	O43424
PDB IDs		6X5Q	5KC8 5KCA
GO Terms Enriched among Interactors		Synapse Modulation Of Chemical Synaptic Transmission Glutamatergic Synapse Regulation Of Protein Localization To Cell Periphery Postsynaptic Density Regulation Of Protein Localization Neuron Projection Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Ionotropic Glutamate Receptor Binding Regulation Of Transport Regulation Of Protein Localization To Membrane Regulation Of Biological Quality Postsynaptic Density Membrane Regulation Of Synaptic Plasticity Plasma Membrane Regulation Of Apoptotic Process Regulation Of Metal Ion Transport Regulation Of Programmed Cell Death Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Regulation Of Monoatomic Ion Transport Positive Regulation Of Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization Intracellular Signaling Cassette Dendrite Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Programmed Cell Death Intracellular Protein Localization Proteolysis Involved In Protein Catabolic Process Proteolysis Chemical Synaptic Transmission AMPA Glutamate Receptor Complex Trans-synaptic Signaling Cortical Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Complex Regulation Of Cellular Localization Protein Phosphorylation Synaptic Signaling Establishment Of Protein Localization Protein Localization To Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Localization To Postsynapse	Glutamate-gated Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Postsynaptic Density Synapse Postsynaptic Density Membrane Regulation Of Presynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Negative Regulation Of Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Complex Receptor Clustering Glutamate Receptor Signaling Pathway Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Localization Within Membrane Glutamate Receptor Binding Postsynaptic Membrane Glutamate-gated Calcium Ion Channel Activity Protein Localization To Membrane Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Long-term Synaptic Depression Postsynaptic Density, Intracellular Component Presynaptic Membrane Dendrite Monoatomic Ion Channel Activity Modulation Of Chemical Synaptic Transmission Neuronal Action Potential Regulation Of Synaptic Plasticity Cell-cell Signaling Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Hippocampal Mossy Fiber To CA3 Synapse Signaling Modulation Of Excitatory Postsynaptic Potential Cell Communication Cell Projection Signaling Receptor Activity Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Excitatory Postsynaptic Potential Extracellularly Glutamate-gated Ion Channel Activity Negative Regulation Of Anion Channel Activity Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels