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GRIA1 and SQSTM1
Number of citations of the paper that reports this interaction (PubMedID
19004011
)
52
Data Source:
HPRD
(in vitro, in vivo)
GRIA1
SQSTM1
Description
glutamate ionotropic receptor AMPA type subunit 1
sequestosome 1
Image
GO Annotations
Cellular Component
Endosome
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Cell-cell Junction
Synaptic Vesicle
Ionotropic Glutamate Receptor Complex
External Side Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Postsynaptic Density
Membrane
Dendrite
Endocytic Vesicle Membrane
Synaptic Vesicle Membrane
Neuromuscular Junction
Early Endosome Membrane
Asymmetric Synapse
AMPA Glutamate Receptor Complex
Dendrite Membrane
Dendritic Spine Membrane
Neuronal Cell Body Membrane
Protein-containing Complex
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Somatodendritic Compartment
Presynaptic Membrane
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Dendritic Shaft
Cell Body
Axonal Spine
Neuron Spine
Synapse
Postsynaptic Membrane
Presynaptic Active Zone Membrane
Recycling Endosome
Recycling Endosome Membrane
Excitatory Synapse
Synaptic Membrane
Presynapse
Postsynapse
Postsynaptic Density Membrane
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Perisynaptic Space
Proximal Dendrite
Phagophore Assembly Site
P-body
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Lysosome
Endosome
Late Endosome
Autophagosome
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Sarcomere
Cytoplasmic Vesicle
Intracellular Membraneless Organelle
Amphisome
Autolysosome
Synapse
Extracellular Exosome
Sperm Midpiece
Lewy Body
Glutamatergic Synapse
Molecular Function
Amyloid-beta Binding
G-protein Alpha-subunit Binding
Glutamate-gated Receptor Activity
AMPA Glutamate Receptor Activity
Monoatomic Ion Channel Activity
Protein Binding
Adenylate Cyclase Binding
Ligand-gated Monoatomic Ion Channel Activity
Immunoglobulin Binding
Protein Kinase Binding
Protein Domain Specific Binding
Glutamate-gated Calcium Ion Channel Activity
PDZ Domain Binding
Small GTPase Binding
Myosin V Binding
G-protein Beta-subunit Binding
Beta-2 Adrenergic Receptor Binding
Glutamate Receptor Binding
Signaling Receptor Activity
Identical Protein Binding
Protein Kinase A Binding
Peptide Hormone Receptor Binding
Scaffold Protein Binding
Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Ionotropic Glutamate Receptor Binding
Signaling Receptor Activity
SH2 Domain Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Ubiquitin-modified Protein Reader Activity
Protein Sequestering Activity
Molecular Sequestering Activity
Molecular Condensate Scaffold Activity
Biological Process
Regulation Of Receptor Recycling
Monoatomic Ion Transport
Signal Transduction
Chemical Synaptic Transmission
Synapse Assembly
Long-term Memory
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Sucrose
Response To Lithium Ion
Positive Regulation Of Gene Expression
Neuronal Action Potential
Calcium-mediated Signaling
Spinal Cord Development
Cerebral Cortex Development
Receptor Internalization
Response To Nutrient Levels
Response To Estradiol
Monoatomic Ion Transmembrane Transport
Regulation Of Monoatomic Ion Transmembrane Transport
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Response To Cocaine
Response To Morphine
Response To Peptide Hormone
Response To Ethanol
Positive Regulation Of Membrane Potential
Response To Arsenic-containing Substance
Regulation Of Synaptic Plasticity
Behavioral Response To Pain
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Synaptic Transmission
Response To Electrical Stimulus
Regulation Of Postsynaptic Membrane Potential
Long-term Synaptic Potentiation
Long-term Synaptic Depression
Response To Fungicide
Cellular Response To Amino Acid Stimulus
Cellular Response To Ammonium Ion
Cellular Response To DsRNA
Cellular Response To Growth Factor Stimulus
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Amine Stimulus
Positive Regulation Of Locomotion Involved In Locomotory Behavior
Regulation Of Presynaptic Membrane Potential
Cellular Response To L-glutamate
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Conditioned Place Preference
Response To Psychosocial Stress
Positive Regulation Of Excitatory Postsynaptic Potential
Negative Regulation Of Transcription By RNA Polymerase II
Autophagy Of Mitochondrion
Mitophagy
Pexophagy
Temperature Homeostasis
Immune System Process
Response To Ischemia
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Import Into Nucleus
Autophagy
Apoptotic Process
Endosome Organization
Intracellular Protein Localization
Positive Regulation Of Autophagy
Regulation Of Mitochondrion Organization
Endosomal Transport
Macroautophagy
Cell Differentiation
Protein Catabolic Process
Negative Regulation Of Protein Ubiquitination
Cellular Response To Stress
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Intracellular Signal Transduction
Aggrephagy
Positive Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Regulation Of Protein Complex Stability
Brown Fat Cell Proliferation
Protein K63-linked Ubiquitination
Protein Targeting To Vacuole Involved In Autophagy
Energy Homeostasis
Response To Mitochondrial Depolarisation
Negative Regulation Of Ferroptosis
Membraneless Organelle Assembly
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
COPII-mediated vesicle transport
Activation of AMPA receptors
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Cargo concentration in the ER
Synaptic adhesion-like molecules
Long-term potentiation
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
PINK1-PRKN Mediated Mitophagy
Neddylation
Interleukin-1 signaling
Pexophagy
Signaling by ALK fusions and activated point mutants
KEAP1-NFE2L2 pathway
Nuclear events mediated by NFE2L2
Drugs
Glutamic acid
Butabarbital
Lamotrigine
Isoflurane
Ethanol
Methoxyflurane
Desflurane
Sevoflurane
Talampanel
CX-717
CX516
Perampanel
Tianeptine
Fluciclovine (18F)
Diseases
Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS
Adult body size (
32376654
)
Aging (time to event) (
21782286
)
Anthropometric traits (
19260139
)
Asparaginase hypersensitivity in acute lymphoblastic leukemia (
20592726
)
Chronotype (
30696823
)
General risk tolerance (MTAG) (
30643258
)
Hand grip strength (
29691431
)
HDL cholesterol levels (
32203549
)
Interleukin-6 levels (
22205395
)
Middle childhood and early adolescence aggressive behavior (
26087016
)
Morning person (
30696823
)
Obesity-related traits (
23251661
)
Post bronchodilator FEV1 in COPD (
26634245
)
Schizophrenia (
30285260
28991256
25056061
23974872
)
Sleep (1/3-day periodicity) (
33075057
)
Sudden cardiac arrest (
21658281
)
Survival in microsatellite instability low/stable colorectal cancer (
25866641
)
Alzheimer's disease (late onset) (
24162737
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Interacting Genes
27 interacting genes:
CACNG2
CAMK2A
CAMK2G
CANX
CASP8
CXCR2
CYLD
DLG1
EPB41L1
EPB41L2
GRIA4
GRID2
GRIK2
GRIP1
GRIPAP1
HOMER1
HSPA5
NEDD4L
PICK1
PRKACA
PRKCA
RPS6KB1
SDCBP
SQSTM1
TANC1
TRPC1
USP46
108 interacting genes:
ACAD10
AIM2
ATXN3
BCL2
BMPR1B
BPTF
BRCA1
CALCR
CALM1
CALR
CAMK2A
CCNF
CDC37
CDC6
CDK1
CRBN
CRYAB
CSNK1A1
DAXX
DAZAP2
DNAI1
DNAI2
DNAJC10
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
HSPA5
IKBKB
IRAK1
KAT5
KCNAB2
KEAP1
KPNA4
LCK
LINC01554
LRRK2
MALT1
MAP1LC3B
MAP2K5
MAPK13
MAPK14
MAPT
MBP
MEIS2
MLH1
MOAP1
MTDH
NBR1
NCOR1
NEDD4
NEDD8
NLRP6
NR2F2
NTRK1
NTRK2
NTRK3
OGT
PADI1
PAWR
PELI1
PIK3CA
PIK3R1
PPHLN1
PRKCD
PRKCI
PRKCZ
RAD23A
RAD54L2
RELN
RIPK1
RNF166
RNF168
RNF26
RPL37
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TGFBR1
TKT
TOE1
TP53INP1
TRAF6
TRIM27
TRIM55
TRIM63
TTN
UBA52
UBB
ULK2
USP8
VANGL2
VAPB
WBP4
WDR81
WEE2-AS1
WWP2
YWHAZ
Entrez ID
2890
8878
HPRD ID
00695
03319
Ensembl ID
ENSG00000155511
ENSG00000161011
Uniprot IDs
A0A9L9PXG3
P42261
Q59GL5
Q13501
PDB IDs
6X5Q
1Q02
2JY7
2JY8
2K0B
2KNV
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
6JM4
6KHZ
6MJ7
6TGY
6TH3
7R1O
Enriched GO Terms of Interacting Partners
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Synapse
Modulation Of Chemical Synaptic Transmission
Glutamatergic Synapse
Regulation Of Protein Localization To Cell Periphery
Postsynaptic Density
Regulation Of Protein Localization
Neuron Projection
Regulation Of Cell Communication
Regulation Of Signaling
Endocytic Vesicle Membrane
Ionotropic Glutamate Receptor Binding
Regulation Of Transport
Regulation Of Protein Localization To Membrane
Regulation Of Biological Quality
Postsynaptic Density Membrane
Regulation Of Synaptic Plasticity
Plasma Membrane
Regulation Of Apoptotic Process
Regulation Of Metal Ion Transport
Regulation Of Programmed Cell Death
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cellular Component Organization
Glutamate Receptor Signaling Pathway
Positive Regulation Of Synaptic Transmission
Regulation Of Monoatomic Ion Transport
Positive Regulation Of Transport
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Protein Localization
Intracellular Signaling Cassette
Dendrite
Positive Regulation Of Protein Localization To Cell Periphery
Negative Regulation Of Programmed Cell Death
Intracellular Protein Localization
Proteolysis Involved In Protein Catabolic Process
Proteolysis
Chemical Synaptic Transmission
AMPA Glutamate Receptor Complex
Trans-synaptic Signaling
Cortical Actin Cytoskeleton Organization
Ionotropic Glutamate Receptor Signaling Pathway
Ionotropic Glutamate Receptor Complex
Regulation Of Cellular Localization
Protein Phosphorylation
Synaptic Signaling
Establishment Of Protein Localization
Protein Localization To Postsynaptic Membrane
Ligand-gated Monoatomic Ion Channel Activity
Protein Localization To Postsynapse
Intracellular Signal Transduction
Regulation Of Signal Transduction
Response To Stress
Regulation Of Cell Communication
Regulation Of Signaling
Cytoplasm
Signal Transduction
Positive Regulation Of Metabolic Process
Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Cytosol
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Metabolic Process
Protein Modification Process
Regulation Of Programmed Cell Death
Positive Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Regulation Of Gene Expression
Cellular Response To Stress
Regulation Of Apoptotic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Regulation Of Multicellular Organismal Process
Positive Regulation Of Macromolecule Biosynthetic Process
Response To Growth Factor
Transferase Activity
Intracellular Signaling Cassette
Regulation Of Primary Metabolic Process
Protein Kinase Activity
Protein-containing Complex
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
MAPK Cascade
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Growth Factor Stimulus
Cellular Response To Oxygen-containing Compound
Regulation Of Protein Metabolic Process
Kinase Activity
Modification-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Serine/threonine Kinase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
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