GRIA1 and GRIP1

Number of citations of the paper that reports this interaction (PubMedID 11891216)
0

Data Source:
BioGRID (pull down)

		GRIA1	GRIP1
Description		glutamate ionotropic receptor AMPA type subunit 1	glutamate receptor interacting protein 1
Image
GO Annotations	Cellular Component	Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell-cell Junction Synaptic Vesicle Ionotropic Glutamate Receptor Complex External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Postsynaptic Density Membrane Dendrite Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuromuscular Junction Early Endosome Membrane Asymmetric Synapse AMPA Glutamate Receptor Complex Dendrite Membrane Dendritic Spine Membrane Neuronal Cell Body Membrane Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Somatodendritic Compartment Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Cell Body Axonal Spine Neuron Spine Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Synaptic Membrane Presynapse Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component Perisynaptic Space Proximal Dendrite	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Dendrite Cytoplasmic Vesicle Cell Projection Neuron Projection Perikaryon Synapse Postsynaptic Membrane
	Molecular Function	Amyloid-beta Binding G-protein Alpha-subunit Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Adenylate Cyclase Binding Ligand-gated Monoatomic Ion Channel Activity Immunoglobulin Binding Protein Kinase Binding Protein Domain Specific Binding Glutamate-gated Calcium Ion Channel Activity PDZ Domain Binding Small GTPase Binding Myosin V Binding G-protein Beta-subunit Binding Beta-2 Adrenergic Receptor Binding Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding Protein Kinase A Binding Peptide Hormone Receptor Binding Scaffold Protein Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Beta-catenin Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Regulation Of Receptor Recycling Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Synapse Assembly Long-term Memory Response To Xenobiotic Stimulus Response To Toxic Substance Response To Sucrose Response To Lithium Ion Positive Regulation Of Gene Expression Neuronal Action Potential Calcium-mediated Signaling Spinal Cord Development Cerebral Cortex Development Receptor Internalization Response To Nutrient Levels Response To Estradiol Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Cocaine Response To Morphine Response To Peptide Hormone Response To Ethanol Positive Regulation Of Membrane Potential Response To Arsenic-containing Substance Regulation Of Synaptic Plasticity Behavioral Response To Pain Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Response To Electrical Stimulus Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Potentiation Long-term Synaptic Depression Response To Fungicide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To DsRNA Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Amine Stimulus Positive Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Presynaptic Membrane Potential Cellular Response To L-glutamate Cellular Response To Brain-derived Neurotrophic Factor Stimulus Conditioned Place Preference Response To Psychosocial Stress Positive Regulation Of Excitatory Postsynaptic Potential	Intracellular Signal Transduction Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization
Pathways		COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules Long-term potentiation	Trafficking of GluR2-containing AMPA receptors
Drugs		Glutamic acid Butabarbital Lamotrigine Isoflurane Ethanol Methoxyflurane Desflurane Sevoflurane Talampanel CX-717 CX516 Perampanel Tianeptine Fluciclovine (18F)
Diseases
GWAS		Adult body size ( 32376654) Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Interleukin-6 levels ( 22205395) Middle childhood and early adolescence aggressive behavior ( 26087016) Morning person ( 30696823) Obesity-related traits ( 23251661) Post bronchodilator FEV1 in COPD ( 26634245) Schizophrenia ( 30285260 28991256 25056061 23974872) Sleep (1/3-day periodicity) ( 33075057) Sudden cardiac arrest ( 21658281) Survival in microsatellite instability low/stable colorectal cancer ( 25866641)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		27 interacting genes: CACNG2 CAMK2A CAMK2G CANX CASP8 CXCR2 CYLD DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 NEDD4L PICK1 PRKACA PRKCA RPS6KB1 SDCBP SQSTM1 TANC1 TRPC1 USP46	46 interacting genes: AGAP2 AR BAG4 CARM1 CSPG4 DEPDC1B DZIP3 EEPD1 EFNA5 EFNB1 EFNB2 EP300 ESR1 FGF12 FLII FXR1 FXR2 GPR37 GRIA1 GRIA3 GRIA4 GRIK1 GRIK2 GRIPAP1 GRM2 GRM3 GRM7 H3C1 HUS1 IRF3 KMT5B MFAP3 NCOA6 NEK6 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA THRA UBE2I VDR WDR6 XDH
Entrez ID		2890	23426
HPRD ID		00695	19086
Ensembl ID		ENSG00000155511	ENSG00000155974
Uniprot IDs		A0A9L9PXG3 P42261 Q59GL5	A0A8V8TLS6 Q9Y3R0
PDB IDs		6X5Q	2JIL
Enriched GO Terms of Interacting Partners?		Synapse Modulation Of Chemical Synaptic Transmission Glutamatergic Synapse Regulation Of Protein Localization To Cell Periphery Postsynaptic Density Regulation Of Protein Localization Neuron Projection Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Ionotropic Glutamate Receptor Binding Regulation Of Transport Regulation Of Protein Localization To Membrane Regulation Of Biological Quality Postsynaptic Density Membrane Regulation Of Synaptic Plasticity Plasma Membrane Regulation Of Apoptotic Process Regulation Of Metal Ion Transport Regulation Of Programmed Cell Death Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Regulation Of Monoatomic Ion Transport Positive Regulation Of Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization Intracellular Signaling Cassette Dendrite Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Programmed Cell Death Intracellular Protein Localization Proteolysis Involved In Protein Catabolic Process Proteolysis Chemical Synaptic Transmission AMPA Glutamate Receptor Complex Trans-synaptic Signaling Cortical Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Complex Regulation Of Cellular Localization Protein Phosphorylation Synaptic Signaling Establishment Of Protein Localization Protein Localization To Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Localization To Postsynapse	Glutamate Receptor Signaling Pathway Regulation Of Cell Communication Glutamate-gated Receptor Activity Nuclear Receptor Activity Presynaptic Membrane Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Chemical Synaptic Transmission Nuclear Receptor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Positive Regulation Of Intracellular Signal Transduction Synaptic Signaling Ligand-gated Monoatomic Ion Channel Activity Regulation Of Biological Quality Glutamate Receptor Activity Regulation Of Synaptic Transmission, Glutamatergic Cell-cell Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synapse Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Transcription Coregulator Binding Cell Communication Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Nuclear Steroid Receptor Activity Postsynaptic Density Membrane AMPA Glutamate Receptor Activity Retinoic Acid Receptor Signaling Pathway MRNA Transcription Regulation Of Presynaptic Membrane Potential Regulation Of Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Glutamatergic Synapse Regulation Of Signal Transduction Estrogen Response Element Binding
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