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DOCK8 and FAM161A
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
DOCK8
FAM161A
Gene Name
dedicator of cytokinesis 8
family with sequence similarity 161, member A
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Membrane
Cell Leading Edge
Cytoplasm
Centrosome
Photoreceptor Connecting Cilium
Ciliary Basal Body
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Binding
Biological Process
Immunological Synapse Formation
Small GTPase Mediated Signal Transduction
Blood Coagulation
Dendritic Cell Migration
Positive Regulation Of GTPase Activity
Memory T Cell Proliferation
Negative Regulation Of T Cell Apoptotic Process
Visual Perception
Cilium Assembly
Response To Stimulus
Pathways
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Mean platelet volume (
22139419
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
25 interactors:
BYSL
CARHSP1
CDC42
CHMP2A
DGCR6
EXOSC5
FAM124A
FAM161A
FANCL
FBXL12
HBZ
KRT40
LRCH1
LRCH3
MED30
MEOX2
MRPL38
MTG1
RAC1
RHOJ
RHOQ
RTP5
SMAD2
ZFC3H1
ZNF581
63 interactors:
BEND3
BEND5
BRCA1
CADPS
CALCOCO1
CALCOCO2
CARD9
CCDC102B
CCDC136
CCDC155
CCDC33
CCDC57
CDR2
CEP44
CEP57L1
CEP63
CEP70
DHX32
DOCK8
EHMT2
FAM9B
FSD2
HMBOX1
IKZF1
KIAA0753
KRTAP10-3
KRTAP10-7
KRTAP10-9
KRTAP5-9
LZTS2
MCM6
MDFI
MID2
MIPOL1
MTUS2
NECAB2
NINL
NUTM1
PDE4DIP
PHC2
PNMA2
POC5
PPFIA1
PPM1F
RINT1
RUNDC3A
SPERT
SSX2IP
STX11
SYCE1
TFIP11
TMCC2
TNIP1
TRAF1
TRIM15
TRIM37
TRIM54
TSGA10
TXLNB
ZBTB1
ZBTB14
ZBTB43
ZBTB8A
Entrez ID
81704
84140
HPRD ID
10920
18996
Ensembl ID
ENSG00000107099
ENSG00000170264
Uniprot IDs
E2J6M5
E2J6M6
Q8NF50
Q3B820
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Anatomical Structure Morphogenesis
Posttranscriptional Regulation Of Gene Expression
Ribosome Biogenesis
Regulation Of Cellular Component Organization
Regulation Of Cytoskeleton Organization
Regulation Of Organelle Organization
Regulation Of Filopodium Assembly
Regulation Of Phosphatidylinositol 3-kinase Activity
Negative Regulation Of Centriole Elongation
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Lipid Kinase Activity
Anatomical Structure Formation Involved In Morphogenesis
Actin Cytoskeleton Organization
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of DNA Replication
Small GTPase Mediated Signal Transduction
Positive Regulation Of Cell Projection Organization
Cell Projection Assembly
Embryonic Olfactory Bulb Interneuron Precursor Migration
Negative Regulation Of Interleukin-23 Production
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Positive Regulation Of Hair Follicle Cell Proliferation
Actin Filament-based Process
T Cell Costimulation
Positive Regulation Of Cellular Component Biogenesis
Ribonucleoprotein Complex Biogenesis
Embryonic Pattern Specification
Regulation Of Protein Complex Assembly
Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Engulfment Of Apoptotic Cell
Submandibular Salivary Gland Formation
Actin Filament Branching
Zygotic Specification Of Dorsal/ventral Axis
Regulation Of Small GTPase Mediated Signal Transduction
Anatomical Structure Development
Ephrin Receptor Signaling Pathway
Intracellular Signal Transduction
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Mast Cell Chemotaxis
Regulation Of Hair Follicle Cell Proliferation
Positive Regulation Of Synapse Structural Plasticity
Palate Development
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Mitotic Nuclear Division
Cell Cycle
Negative Regulation Of RNA Biosynthetic Process
Organelle Organization
Negative Regulation Of Centriole Replication
Cell Cycle Process
Negative Regulation Of Gene Expression
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Synapsis
Homologous Chromosome Segregation
Negative Regulation Of Cytoskeleton Organization
Regulation Of Centriole Replication
Leukocyte Cell-cell Adhesion
Cellular Component Assembly
Negative Regulation Of Viral Process
Negative Regulation Of Viral Release From Host Cell
Meiotic Chromosome Segregation
Negative Regulation Of Centrosome Duplication
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of RNA Biosynthetic Process
Centrosome Organization
Chromosome Segregation
Negative Regulation Of Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Viral Release From Host Cell
Regulation Of Nitrogen Compound Metabolic Process
Synaptonemal Complex Assembly
Microtubule Cytoskeleton Organization
Meiosis I
Microtubule Organizing Center Organization
Synaptonemal Complex Organization
Neurotransmitter Secretion
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
G2/M Transition Of Mitotic Cell Cycle
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Chromosome Organization
Regulation Of Cytoskeleton Organization
Microtubule-based Process
Regulation Of Neurotransmitter Levels
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Neutrophil Differentiation
Positive Regulation Of Histone H4-K20 Methylation
Tagcloud
?
akr1c4
anomalies
apparently
array
balanced
bases
cdon
cgh
chrna7
confirming
dd
diagnoses
gata3
id
indistinguishable
inherited
intellectual
karyotype
karyotyping
mb
mca
nr2f2
overlooked
prenatal
pws
rearrangements
spanning
tier
tp63
Tagcloud (Difference)
?
akr1c4
anomalies
apparently
array
balanced
bases
cdon
cgh
chrna7
confirming
dd
diagnoses
gata3
id
indistinguishable
inherited
intellectual
karyotype
karyotyping
mb
mca
nr2f2
overlooked
prenatal
pws
rearrangements
spanning
tier
tp63
Tagcloud (Intersection)
?