DOCK8 and ZFC3H1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DOCK8	ZFC3H1
Description		dedicator of cytokinesis 8	zinc finger C3H1-type containing
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cell Leading Edge Leading Edge Membrane Lamellipodium Membrane Cell Projection	Extracellular Space Nucleus Nucleolus MTREC Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Immunological Synapse Formation Small GTPase-mediated Signal Transduction Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration	RNA Processing
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle Factors involved in megakaryocyte development and platelet production	Nuclear RNA decay
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation
GWAS		Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 27863252 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Post bronchodilator FEV1 ( 26634245) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494) Youthful appearance (self-reported) ( 32339537)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		27 interacting genes: BYSL CARHSP1 CDC42 CEBPA CHMP2A COG6 DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ HSF2BP KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	23 interacting genes: APP CADPS CCDC57 CCDC85B CEP70 COG6 CSNK2A1 DOCK8 GOLGA2 GRIK1 HNRNPK HSF2BP ITSN1 KHDRBS2 MKRN3 MTUS2 NINL PIBF1 RNF10 SPAG5 SRPK2 TRIM27 ZDHHC17
Entrez ID		81704	196441
HPRD ID		10920	14489
Ensembl ID		ENSG00000107099	ENSG00000133858
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	O60293
PDB IDs
Enriched GO Terms of Interacting Partners?		GBD Domain Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Membrane Invagination Thioesterase Binding GTPase Activity Golgi Transport Complex Establishment Or Maintenance Of Cell Polarity GTP Binding Cytoplasmic Exosome (RNase Complex)	Centrosome
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