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DOCK8 and RHOQ
Number of citations of the paper that reports this interaction (PMID
15304341
)
13
Data Source:
HPRD
(two hybrid)
DOCK8
RHOQ
Gene Name
dedicator of cytokinesis 8
ras homolog family member Q
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Membrane
Cell Leading Edge
Cytosol
Actin Filament
Plasma Membrane
Membrane Raft
Extracellular Vesicular Exosome
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
GTPase Activity
Profilin Binding
GTP Binding
GBD Domain Binding
Biological Process
Immunological Synapse Formation
Small GTPase Mediated Signal Transduction
Blood Coagulation
Dendritic Cell Migration
Positive Regulation Of GTPase Activity
Memory T Cell Proliferation
Negative Regulation Of T Cell Apoptotic Process
Small GTPase Mediated Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Cell Shape
Cortical Actin Cytoskeleton Organization
Cellular Response To Insulin Stimulus
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Glucose Import
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Filopodium Assembly
Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways
Factors involved in megakaryocyte development and platelet production
Rho GTPase cycle
Signaling by Rho GTPases
Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS
Mean platelet volume (
22139419
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
25 interactors:
BYSL
CARHSP1
CDC42
CHMP2A
DGCR6
EXOSC5
FAM124A
FAM161A
FANCL
FBXL12
HBZ
KRT40
LRCH1
LRCH3
MED30
MEOX2
MRPL38
MTG1
RAC1
RHOJ
RHOQ
RTP5
SMAD2
ZFC3H1
ZNF581
18 interactors:
CDC42BPG
CDC42EP1
CDC42EP2
CDC42EP3
CDC42EP4
COPB1
COPG1
DOCK8
EXOC7
GOPC
PARD6A
PARD6B
PFN1
PRKCI
RAPGEF1
TRIP10
TRIP6
WASL
Entrez ID
81704
23433
HPRD ID
10920
05791
Ensembl ID
ENSG00000107099
Uniprot IDs
E2J6M5
E2J6M6
Q8NF50
P17081
PDB IDs
2ATX
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Anatomical Structure Morphogenesis
Posttranscriptional Regulation Of Gene Expression
Ribosome Biogenesis
Regulation Of Cellular Component Organization
Regulation Of Cytoskeleton Organization
Regulation Of Organelle Organization
Regulation Of Filopodium Assembly
Regulation Of Phosphatidylinositol 3-kinase Activity
Negative Regulation Of Centriole Elongation
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Lipid Kinase Activity
Anatomical Structure Formation Involved In Morphogenesis
Actin Cytoskeleton Organization
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of DNA Replication
Small GTPase Mediated Signal Transduction
Positive Regulation Of Cell Projection Organization
Cell Projection Assembly
Embryonic Olfactory Bulb Interneuron Precursor Migration
Negative Regulation Of Interleukin-23 Production
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Positive Regulation Of Hair Follicle Cell Proliferation
Actin Filament-based Process
T Cell Costimulation
Positive Regulation Of Cellular Component Biogenesis
Ribonucleoprotein Complex Biogenesis
Embryonic Pattern Specification
Regulation Of Protein Complex Assembly
Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Engulfment Of Apoptotic Cell
Submandibular Salivary Gland Formation
Actin Filament Branching
Zygotic Specification Of Dorsal/ventral Axis
Regulation Of Small GTPase Mediated Signal Transduction
Anatomical Structure Development
Ephrin Receptor Signaling Pathway
Intracellular Signal Transduction
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Mast Cell Chemotaxis
Regulation Of Hair Follicle Cell Proliferation
Positive Regulation Of Synapse Structural Plasticity
Palate Development
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Mitotic Nuclear Division
Positive Regulation Of Cell Projection Organization
Positive Regulation Of Pseudopodium Assembly
Regulation Of Cell Projection Assembly
Regulation Of Cell Projection Organization
Positive Regulation Of Cytoskeleton Organization
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Protein Polymerization
Positive Regulation Of Cellular Component Biogenesis
Golgi Vesicle Budding
Positive Regulation Of Protein Complex Assembly
Regulation Of Actin Cytoskeleton Organization
Regulation Of Actin Filament Polymerization
Regulation Of Actin Polymerization Or Depolymerization
Regulation Of Actin Filament Length
Membrane Budding
Positive Regulation Of Organelle Organization
Regulation Of Actin Filament-based Process
Regulation Of Cytoskeleton Organization
Regulation Of Catalytic Activity
Intracellular Signal Transduction
Regulation Of Cellular Component Size
Actin Cytoskeleton Organization
Regulation Of Cellular Component Organization
Regulation Of Protein Complex Assembly
Small GTPase Mediated Signal Transduction
Localization Within Membrane
Vesicle-mediated Transport
Actin Filament-based Process
Positive Regulation Of Hydrolase Activity
Regulation Of Cell Shape
Tight Junction Assembly
Rho Protein Signal Transduction
Positive Regulation Of GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Ras GTPase Activity
Cell Junction Assembly
Regulation Of GTPase Activity
Vesicle Organization
Cell-cell Junction Organization
Ras Protein Signal Transduction
Apical Junction Assembly
Organelle Organization
Positive Regulation Of Rho GTPase Activity
COPI-coated Vesicle Budding
COPI Coating Of Golgi Vesicle
Regulation Of Organelle Organization
Regulation Of Ras GTPase Activity
Golgi Vesicle Transport
Regulation Of Rho GTPase Activity
Positive Regulation Of Catalytic Activity
Tagcloud
?
akr1c4
anomalies
apparently
array
balanced
bases
cdon
cgh
chrna7
confirming
dd
diagnoses
gata3
id
indistinguishable
inherited
intellectual
karyotype
karyotyping
mb
mca
nr2f2
overlooked
prenatal
pws
rearrangements
spanning
tier
tp63
Tagcloud (Difference)
?
akr1c4
anomalies
apparently
array
balanced
bases
cdon
cgh
chrna7
confirming
dd
diagnoses
gata3
id
indistinguishable
inherited
intellectual
karyotype
karyotyping
mb
mca
nr2f2
overlooked
prenatal
pws
rearrangements
spanning
tier
tp63
Tagcloud (Intersection)
?