DOCK8

Description		dedicator of cytokinesis 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cell Leading Edge Leading Edge Membrane Lamellipodium Membrane Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Immunological Synapse Formation Small GTPase-mediated Signal Transduction Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation
GWAS		Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 27863252 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Post bronchodilator FEV1 ( 26634245) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		27 interacting genes: BYSL CARHSP1 CDC42 CEBPA CHMP2A COG6 DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ HSF2BP KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581
Entrez ID		81704
HPRD ID		10920
Ensembl ID		ENSG00000107099
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50
PDB IDs
Enriched GO Terms of Interacting Partners?		GBD Domain Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Membrane Invagination Thioesterase Binding GTPase Activity Golgi Transport Complex Establishment Or Maintenance Of Cell Polarity GTP Binding Cytoplasmic Exosome (RNase Complex)
Tagcloud ?