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DOCK8 and RHOJ
Number of citations of the paper that reports this interaction (PMID
15304341
)
13
Data Source:
HPRD
(two hybrid)
DOCK8
RHOJ
Gene Name
dedicator of cytokinesis 8
ras homolog family member J
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Membrane
Cell Leading Edge
Cytosol
Plasma Membrane
Extracellular Vesicular Exosome
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
GTPase Activity
GTP Binding
Biological Process
Immunological Synapse Formation
Small GTPase Mediated Signal Transduction
Blood Coagulation
Dendritic Cell Migration
Positive Regulation Of GTPase Activity
Memory T Cell Proliferation
Negative Regulation Of T Cell Apoptotic Process
Small GTPase Mediated Signal Transduction
Rho Protein Signal Transduction
Metabolic Process
Regulation Of Cell Shape
Actin Cytoskeleton Organization
Regulation Of Small GTPase Mediated Signal Transduction
Retina Vasculature Morphogenesis In Camera-type Eye
Pathways
Factors involved in megakaryocyte development and platelet production
Rho GTPase cycle
Signaling by Rho GTPases
Drugs
Diseases
GWAS
Mean platelet volume (
22139419
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
25 interactors:
BYSL
CARHSP1
CDC42
CHMP2A
DGCR6
EXOSC5
FAM124A
FAM161A
FANCL
FBXL12
HBZ
KRT40
LRCH1
LRCH3
MED30
MEOX2
MRPL38
MTG1
RAC1
RHOJ
RHOQ
RTP5
SMAD2
ZFC3H1
ZNF581
21 interactors:
ACVR1
ADAMTSL4
BHLHE40
BLZF1
BMPR1B
CDC42
CDC42EP1
DOCK10
DOCK8
MEOX2
PAK1
PAK2
PAK6
PARD6B
SMAD2
SMAD4
SSX3
TGFBR1
TRIP10
WAS
WASL
Entrez ID
81704
57381
HPRD ID
10920
09632
Ensembl ID
ENSG00000107099
ENSG00000126785
Uniprot IDs
E2J6M5
E2J6M6
Q8NF50
Q7Z513
Q9H4E5
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Regulation Of Substrate Adhesion-dependent Cell Spreading
Anatomical Structure Morphogenesis
Posttranscriptional Regulation Of Gene Expression
Ribosome Biogenesis
Regulation Of Cellular Component Organization
Regulation Of Cytoskeleton Organization
Regulation Of Organelle Organization
Regulation Of Filopodium Assembly
Regulation Of Phosphatidylinositol 3-kinase Activity
Negative Regulation Of Centriole Elongation
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Lipid Kinase Activity
Anatomical Structure Formation Involved In Morphogenesis
Actin Cytoskeleton Organization
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of DNA Replication
Small GTPase Mediated Signal Transduction
Positive Regulation Of Cell Projection Organization
Cell Projection Assembly
Embryonic Olfactory Bulb Interneuron Precursor Migration
Negative Regulation Of Interleukin-23 Production
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Positive Regulation Of Hair Follicle Cell Proliferation
Actin Filament-based Process
T Cell Costimulation
Positive Regulation Of Cellular Component Biogenesis
Ribonucleoprotein Complex Biogenesis
Embryonic Pattern Specification
Regulation Of Protein Complex Assembly
Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Engulfment Of Apoptotic Cell
Submandibular Salivary Gland Formation
Actin Filament Branching
Zygotic Specification Of Dorsal/ventral Axis
Regulation Of Small GTPase Mediated Signal Transduction
Anatomical Structure Development
Ephrin Receptor Signaling Pathway
Intracellular Signal Transduction
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Mast Cell Chemotaxis
Regulation Of Hair Follicle Cell Proliferation
Positive Regulation Of Synapse Structural Plasticity
Palate Development
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Mitotic Nuclear Division
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cell Morphogenesis Involved In Differentiation
Signal Transduction By Phosphorylation
Movement Of Cell Or Subcellular Component
Axonogenesis
Axon Development
Regulation Of Metabolic Process
Cell Morphogenesis Involved In Neuron Differentiation
Locomotion
Regulation Of Cellular Process
Axon Guidance
Neuron Projection Morphogenesis
Cell Development
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Anatomical Structure Morphogenesis
Cell Morphogenesis
Activin Receptor Signaling Pathway
Signal Transduction
Palate Development
Pattern Specification Process
Neuron Differentiation
Regulation Of Cell Projection Assembly
Fc Receptor Signaling Pathway
Neuron Projection Development
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Fate Commitment
Signaling
Cell Projection Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Part Morphogenesis
Regulation Of Signal Transduction
Cell Communication
Positive Regulation Of Cellular Component Biogenesis
Positive Regulation Of Signal Transduction
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Tissue Development
Regulation Of Nitrogen Compound Metabolic Process
Chemotaxis
Regulation Of Filopodium Assembly
Peptidyl-threonine Phosphorylation
Endocardial Cell Differentiation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Neuron Development
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Cellular Response To Transforming Growth Factor Beta Stimulus
Tagcloud
?
akr1c4
anomalies
apparently
array
balanced
bases
cdon
cgh
chrna7
confirming
dd
diagnoses
gata3
id
indistinguishable
inherited
intellectual
karyotype
karyotyping
mb
mca
nr2f2
overlooked
prenatal
pws
rearrangements
spanning
tier
tp63
Tagcloud (Difference)
?
akr1c4
anomalies
apparently
array
balanced
bases
cdon
cgh
chrna7
confirming
dd
diagnoses
gata3
id
indistinguishable
inherited
intellectual
karyotype
karyotyping
mb
mca
nr2f2
overlooked
prenatal
pws
rearrangements
spanning
tier
tp63
Tagcloud (Intersection)
?