DOCK8 and RHOJ

Number of citations of the paper that reports this interaction (PubMedID 15304341)
0

Data Source:
HPRD (two hybrid)

		DOCK8	RHOJ
Description		dedicator of cytokinesis 8	ras homolog family member J
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cell Leading Edge Leading Edge Membrane Lamellipodium Membrane Cell Projection	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Immunological Synapse Formation Small GTPase-mediated Signal Transduction Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration	Angiogenesis Endocytosis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Establishment Of Cell Polarity Actin Cytoskeleton Organization Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle Factors involved in megakaryocyte development and platelet production	RHOJ GTPase cycle
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation
GWAS		Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 27863252 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Post bronchodilator FEV1 ( 26634245) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494) Youthful appearance (self-reported) ( 32339537)	Endometriosis ( 28881265) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)
Interacting Genes		27 interacting genes: BYSL CARHSP1 CDC42 CEBPA CHMP2A COG6 DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ HSF2BP KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	22 interacting genes: ACVR1 ADAMTSL4 BHLHE40 BLZF1 BMPR1B CDC42 DOCK10 DOCK8 GOLGA2 MEOX2 PAK1 PAK3 PAK5 PAK6 PARD6B SMAD2 SMAD4 SSX3 TGFBR1 TRIP10 WAS ZNF426
Entrez ID		81704	57381
HPRD ID		10920	09632
Ensembl ID		ENSG00000107099	ENSG00000126785
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	Q7Z513 Q9H4E5
PDB IDs
Enriched GO Terms of Interacting Partners?		GBD Domain Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Membrane Invagination Thioesterase Binding GTPase Activity Golgi Transport Complex Establishment Or Maintenance Of Cell Polarity GTP Binding Cytoplasmic Exosome (RNase Complex)	SMAD Binding Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Protein Serine/threonine Kinase Activity Anatomical Structure Morphogenesis Cell Migration Ameboidal-type Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Regionalization Cell Projection Morphogenesis Neuron Projection Morphogenesis I-SMAD Binding Dendritic Spine Morphogenesis Protein Kinase Activity Regulation Of Cell Motility Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Motility Roof Of Mouth Development Regulation Of Locomotion Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Activin Responsive Factor Complex Regulation Of Actin Filament-based Process Intracellular Signaling Cassette Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Kinase Activity Cellular Response To BMP Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Dendritic Spine Organization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cell Migration Ventricular Septum Morphogenesis Regulation Of Actin Filament Organization Positive Regulation Of SMAD Protein Signal Transduction Tissue Development Neuron Projection Organization Postsynapse Organization Gastrulation Activin Receptor Complex Activin Receptor Activity, Type I SMAD Protein Complex Trophoblast Cell Migration Positive Regulation Of Stress Fiber Assembly
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