DOCK8 and FBXL12

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DOCK8	FBXL12
Gene Name		dedicator of cytokinesis 8	F-box and leucine-rich repeat protein 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Cell Leading Edge	Ubiquitin Ligase Complex Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419) Obesity-related traits ( 23251661)
Protein-Protein Interactions		25 interactors: BYSL CARHSP1 CDC42 CHMP2A DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ KRT40 LRCH1 LRCH3 MED30 MEOX2 MRPL38 MTG1 RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	14 interactors: A2M APOE CDC37 CDKN1C DOCK8 ECSIT FXYD3 LNX1 MAST1 PSEN1 PSEN2 RNF32 SMAD1 TGFBR1
Entrez ID		81704	54850
HPRD ID		10920	12363
Ensembl ID		ENSG00000107099	ENSG00000127452
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	Q9NXK8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Morphogenesis Regulation Of Cell Projection Assembly Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Substrate Adhesion-dependent Cell Spreading Anatomical Structure Morphogenesis Posttranscriptional Regulation Of Gene Expression Ribosome Biogenesis Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Filopodium Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Centriole Elongation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Lipid Kinase Activity Anatomical Structure Formation Involved In Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of DNA Replication Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Projection Organization Cell Projection Assembly Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Hair Follicle Cell Proliferation Actin Filament-based Process T Cell Costimulation Positive Regulation Of Cellular Component Biogenesis Ribonucleoprotein Complex Biogenesis Embryonic Pattern Specification Regulation Of Protein Complex Assembly Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Engulfment Of Apoptotic Cell Submandibular Salivary Gland Formation Actin Filament Branching Zygotic Specification Of Dorsal/ventral Axis Regulation Of Small GTPase Mediated Signal Transduction Anatomical Structure Development Ephrin Receptor Signaling Pathway Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Mast Cell Chemotaxis Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Palate Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Mitotic Nuclear Division	Regulation Of Catalytic Activity Embryonic Morphogenesis Intracellular Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Thymus Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Generation Of Neurons Amyloid Precursor Protein Catabolic Process Anatomical Structure Morphogenesis Neurogenesis Regulation Of Protein Phosphorylation Cell Fate Commitment Neuron Differentiation Embryo Development Negative Regulation Of Protein Phosphorylation Cell Activation Response To Wounding Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Phosphorylation Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Response To Cholesterol Regulation Of Protein Binding Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Nervous System Development Regulation Of Cell Death Regulation Of Synaptic Plasticity Regulation Of Cell Morphogenesis Pattern Specification Process Regulation Of Cell Projection Organization Neuron Development Gland Development Cell Differentiation Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Metabolic Process Response To Stress Dorsal/ventral Neural Tube Patterning Negative Regulation Of Endothelial Cell Proliferation
Tagcloud ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Difference) ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Intersection) ?