DOCK8 and CARHSP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DOCK8	CARHSP1
Gene Name		dedicator of cytokinesis 8	calcium regulated heat stable protein 1, 24kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Cell Leading Edge	Cytoplasmic Exosome (RNase Complex) Cytoplasmic MRNA Processing Body Cytosol P Granule Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	DNA Binding MRNA 3'-UTR Binding Phosphatase Binding
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process	Regulation Of Transcription, DNA-templated Intracellular Signal Transduction Regulation Of MRNA Stability
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419) Obesity-related traits ( 23251661)
Protein-Protein Interactions		25 interactors: BYSL CARHSP1 CDC42 CHMP2A DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ KRT40 LRCH1 LRCH3 MED30 MEOX2 MRPL38 MTG1 RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	17 interactors: AKT1 DOCK8 KRTAP10-3 KRTAP10-7 KRTAP10-8 NOTCH2NL PIAS3 PIN1 PNMA1 RPS6KA1 SGK1 SMN1 STC2 STYX TK1 TRAF1 TSC22D1
Entrez ID		81704	23589
HPRD ID		10920	08515
Ensembl ID		ENSG00000107099	ENSG00000153048
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	Q9Y2V2
PDB IDs			3AQQ
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Morphogenesis Regulation Of Cell Projection Assembly Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Substrate Adhesion-dependent Cell Spreading Anatomical Structure Morphogenesis Posttranscriptional Regulation Of Gene Expression Ribosome Biogenesis Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Filopodium Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Centriole Elongation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Lipid Kinase Activity Anatomical Structure Formation Involved In Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of DNA Replication Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Projection Organization Cell Projection Assembly Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Hair Follicle Cell Proliferation Actin Filament-based Process T Cell Costimulation Positive Regulation Of Cellular Component Biogenesis Ribonucleoprotein Complex Biogenesis Embryonic Pattern Specification Regulation Of Protein Complex Assembly Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Engulfment Of Apoptotic Cell Submandibular Salivary Gland Formation Actin Filament Branching Zygotic Specification Of Dorsal/ventral Axis Regulation Of Small GTPase Mediated Signal Transduction Anatomical Structure Development Ephrin Receptor Signaling Pathway Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Mast Cell Chemotaxis Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Palate Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Mitotic Nuclear Division	Regulation Of Apoptotic Process Regulation Of Cell Death Maternal Placenta Development Regulation Of Growth Glycogen Cell Differentiation Involved In Embryonic Placenta Development Fetal Process Involved In Parturition Memory T Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Regulation Of Cell Growth Multicellular Organismal Reproductive Process Maternal Process Involved In Female Pregnancy Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Multicellular Organism Reproduction Negative Regulation Of Cysteine-type Endopeptidase Activity Skeletal Muscle Cell Proliferation Positive Regulation Of Hepatic Stellate Cell Activation MAPK Export From Nucleus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Stress Response To Hormone Response To Nutrient Levels Cellular Response To Oxygen Levels Response To Organic Substance Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Cell Growth Programmed Cell Death Response To Extracellular Stimulus Renal Sodium Ion Absorption Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Metabolic Process Reproduction Cell Death Death Renal Sodium Ion Transport Response To UV-A Response To Cortisol Thymidine Metabolic Process Negative Regulation Of MAPK Cascade Activation-induced Cell Death Of T Cells Regulation Of Gastric Acid Secretion Single Organism Reproductive Process Positive Regulation Of Apoptotic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Difference) ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Intersection) ?