DOCK8 and MRPL38

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DOCK8	MRPL38
Gene Name		dedicator of cytokinesis 8	mitochondrial ribosomal protein L38
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Cell Leading Edge	Mitochondrial Inner Membrane Ribosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process	Organelle Organization Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		Factors involved in megakaryocyte development and platelet production	Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419) Obesity-related traits ( 23251661)
Protein-Protein Interactions		25 interactors: BYSL CARHSP1 CDC42 CHMP2A DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ KRT40 LRCH1 LRCH3 MED30 MEOX2 MRPL38 MTG1 RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	6 interactors: C14orf1 CSNK2A1 DOCK8 HSPB3 PRIM1 PRMT6
Entrez ID		81704	64978
HPRD ID		10920	14758
Ensembl ID		ENSG00000107099	ENSG00000204316
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	Q96DV4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Morphogenesis Regulation Of Cell Projection Assembly Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Substrate Adhesion-dependent Cell Spreading Anatomical Structure Morphogenesis Posttranscriptional Regulation Of Gene Expression Ribosome Biogenesis Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Filopodium Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Centriole Elongation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Lipid Kinase Activity Anatomical Structure Formation Involved In Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of DNA Replication Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Projection Organization Cell Projection Assembly Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Hair Follicle Cell Proliferation Actin Filament-based Process T Cell Costimulation Positive Regulation Of Cellular Component Biogenesis Ribonucleoprotein Complex Biogenesis Embryonic Pattern Specification Regulation Of Protein Complex Assembly Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Engulfment Of Apoptotic Cell Submandibular Salivary Gland Formation Actin Filament Branching Zygotic Specification Of Dorsal/ventral Axis Regulation Of Small GTPase Mediated Signal Transduction Anatomical Structure Development Ephrin Receptor Signaling Pathway Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Mast Cell Chemotaxis Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Palate Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Mitotic Nuclear Division
Tagcloud ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63	arose ccl8 cfl1 consistently cox8b eif4a eif4b fourfold hoxd13 immature lbl leukemias leukemic littermates lmo1 lymphoblastic nhd13 nup98 okadaic overexpressed pbx3 prss16 situation tcra tcrb thymic thymocytes transgenic underexpressed
Tagcloud (Difference) ?		akr1c4 anomalies apparently array balanced bases cdon cgh chrna7 confirming dd diagnoses gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63	arose ccl8 cfl1 consistently cox8b eif4a eif4b fourfold hoxd13 immature lbl leukemias leukemic littermates lmo1 lymphoblastic nhd13 nup98 okadaic overexpressed pbx3 prss16 situation tcra tcrb thymic thymocytes transgenic underexpressed
Tagcloud (Intersection) ?